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Zanaflex (Tizanidine)

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Zanaflex is in a class of medications called skeletal muscle relaxants. It works by slowing action in the brain and nervous system to allow the muscles to relax. Zanaflex is used to relieve the spasms and increased muscle tone caused by multiple sclerosis.

Other names for this medication:

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Also known as: Tizanidine


Generic Zanaflex is an agonist at (alpha) 2-adrenergic receptor sites and presumably reduces spasticity by increasing presynaptic inhibition of motor neurons. In animal models, Generic Zanaflex has no direct effect on skeletal muscle fibers or the neuromuscular junction, and no major effect on monosynaptic spinal reflexes. The effects of Generic Zanaflex are greatest on polysynaptic pathways. The overall effect of these actions is thought to reduce facilitation of spinal motor neurons. The imidazoline chemical structure of Generic Zanaflex is related to that of the anti-hypertensive drug clonidine and other (alpha) 2 -adrenergic agonists. Pharmacological studies in animals show similarities between the two compounds, but Generic Zanaflex was found to have one-tenth to one-fiftieth (1/50) of the potency of clonidine in lowering blood pressure. Zanaflex is also known as Tizanidine, Sirdalud. Generic name of Generic Zanaflex is Tizanidine-Oral. Brand name of Generic Zanaflex is Zanaflex.


You should take it by mouth. It usually is taken two or three times a day. If you want to achieve most effective results do not stop taking Generic Zanaflex suddenly.


If you overdose Generic Zanaflex and you don't feel good you should visit your doctor or health care provider immediately.


Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Zanaflex are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Appropriate studies performed to date have not demonstrated geriatrics-specific problems that would limit the usefulness of tizanidine in the elderly. However, elderly patients are more likely to have kidney problems, which may require caution in patients receiving this medicine.

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Initial multi-institutional experience with transoral robotic surgery. In particular, in patients with NF2 who already have unilateral hearing loss, avoidance of hearing loss on the opposite side poses a challenge for RS and SRT. The dexamethasone suppression test (DST) was performed on 21 patients with dementia of the Alzheimer type (DAT), 11 patients with multi-infarct dementia (MI) and 14 healthy controls. Premature aging, associated thymic involution, and compensatory autoproliferation could play important roles in the pathogenesis of autoimmunity. A 50-year-old woman presented with chronic epigastric abdominal pain and constipation.

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Selective 3-(O-carboxymethyl)oxime formation in steroidal 3,20-diones for hapten immunospecificity. As their effects on sleep variables differ considerably, the aim of the present placebo-controlled sleep laboratory study was to measure the acute effects of 1 mg clonazepam on objective and subjective sleep and awakening quality in ten RLS and 16 PLMD patients, utilizing polysomnography (PSG) and psychometry. This suggests that tolerance is unlikely to be caused by reduced bioavailability or accelerated elimination of tofranil medication ISDN. Due to this initiative it will be possible to distribute widely International Hazard Datasheets on Occupations and thus help people in their choice of occupation before employment, and to up-date data according to technological progress and organisational changes. Gender-specific effect of estrogen receptor-1 gene polymorphisms in coronary artery disease and its angiographic severity in Chinese population. Experiences in the Resuscitation Center of the Claude Bernard Hospital. In contrast to ZNF74-I, which largely colocalizes with SC-35 in nuclear speckles enriched in splicing factors, the transcriptionally active ZNF74-II had a more diffuse nuclear distribution that is more characteristic of transcriptional regulators. Highly efficient transduction of human monocyte-derived dendritic cells with subgroup B fiber-modified adenovirus vectors enhances transgene-encoded antigen presentation to cytotoxic T cells. Chronic total occlusion treatment as a health insurance: collateral recruitability and bidirectionality.

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A novel autosomal dominant distal myopathy with early respiratory failure: clinico-pathologic characteristics and exclusion of linkage to candidate genetic loci. TRP14 contributes to this inhibitory activity by maintaining LC8 in a reduced state. Investigation of Polymorphism and Cocrystallization of Active Pharmaceutical Ingredients Using Vibrational Spectroscopic Techniques. To compare the surgical results of vitrectomy and scleral buckling for uncomplicated superior retinal detachment caused by flap tears. Colorimetric Fluorescent Nanosensor Based on Hexamethylene Diisocyanate for Fluorescent Responses and Adsorption of Heavy Metal Ions. Regulation and localization of the Bloom syndrome protein in response to DNA damage. We should consider the possibility of multiple sclerosis as the underlying origin in patients with granulomatous uveitis. The preliminary in vitro and in vivo studies of the phage-display S.

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Anti-citrullinated peptide/protein antibodies and structural prognosis of rheumatoid arthritis: quantity versus quality. Catheter-related infections are a major problem for hemodialysis patients with central venous catheters for vascular access. Phase II and pharmacokinetic study of high-dose methotrexate in the treatment of advanced gynecologic malignancy. This can be associated with the unique structure of their proboscises, with micro/nano sawteeth, and the distinctive insertion manner: high frequency reciprocating saw cutting. In eight patients with chronic paroxysmal hemicrania (CPH), forehead sweating was measured after various provocation tests-body heating, exercise, and subcutaneous pilocarpine administration (0.1 mg/kg body weight). Insulin-stimulated glucose uptake is mediated by the glucose transporter 4 (GLUT4), which is expressed mainly in skeletal muscle and adipose tissue. Five types of basket cell in the hippocampal dentate gyrus: a combined Golgi and electron microscopic study.

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