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Xepalat (Nifedipine)

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Xepalat is a drug that performs by relaxing the muscles inside the heart and blood vessels in order to enable easier blood flow. This enables the heart to have an easier time pumping blood. The active ingredient is nifedipine and it a part of a class of drugs called calcium channel blockers. The primary use of this medication is to help stop chest pain (angina) and help treat high blood pressure problems (hypertension). In addition to this it can also be used in order to heighten the supply of oxygen and blood to the heart and help with a specific blood circulation condition called Raynaud’s phenomenon.

Other names for this medication:
Anpect, Atenerate, Belnif, Bresben, Cardifen, Conducil, Coral, Cordaflex, Cordilat, Corinfar, Corotrend, Depin, Herlat, Nicardia, Nidilat, Nifangin, Nifecor, Nifed, Nifedicor, Nifensar, Nipidin, Nirena, Ospocard, Siopelmin, Valni, Viscard, Zenusin

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Also known as: Nifedipine


Nifedipine is used alone or together with other medicines to treat severe chest pain (angina) or high blood pressure (hypertension). High blood pressure adds to the workload of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. High blood pressure may also increase the risk of heart attacks. These problems may be less likely to occur if blood pressure is controlled.

Nifedipine is a calcium channel blocker. It works by affecting the movement of calcium into the cells of the heart and blood vessels. As a result, nifedipine relaxes blood vessels and increases the supply of blood and oxygen to the heart while reducing its workload.

This medicine is available only with your doctor's prescription.


This section provides information on the proper use of a number of products that contain nifedipine. It may not be specific to Xepalat. Please read with care.

In addition to the use of this medicine, treatment for your high blood pressure may include weight control and changes in the types of foods you eat, especially foods high in sodium (salt). Your doctor will tell you which of these are most important for you. You should check with your doctor before changing your diet.

Many patients who have high blood pressure will not notice any signs of the problem. In fact, many may feel normal. It is very important that you take your medicine exactly as directed and that you keep your appointments with your doctor even if you feel well.

Remember that this medicine will not cure your high blood pressure, but it does help control it. You must continue to take it as directed if you expect to lower your blood pressure and keep it down. You may have to take high blood pressure medicine for the rest of your life. If high blood pressure is not treated, it can cause serious problems such as heart failure, blood vessel disease, stroke, or kidney disease.

Swallow the extended release tablet whole. Do not break, crush, or chew it. It is best to take this tablet on an empty stomach.

If you are taking the extended-release tablets, part of the tablet may pass into your stool after your body has absorbed the medicine. This is normal and nothing to worry about.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For treatment of chest pain or high blood pressure: For oral dosage form (capsules): Adults—At first, 10 milligrams (mg) three times a day. Your doctor may increase your dose as needed. Children—Use and dose must be determined by your doctor. For oral dosage form (extended-release tablets): Adults—At first, 30 or 60 milligrams (mg) once a day. Your doctor may increase your dose as needed. However, the dose is usually not more than 90 mg once a day. Children—Use and dose must be determined by your doctor.


If you overdose Xepalat and you don't feel good you should visit your doctor or health care provider immediately.


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Detailed Nifedipine dosage information

Side effects

The most common side effects associated with Xepalat are:

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Inflammatory responses of human primary macrophages to particulate bone cements in vitro. Salmonella, on the other hand, are facultative aerobes that can grow aerobically or anaerobically and, therefore, grow on viable tumor tissue as well as necrotic tissue. Oral hyposensitization in patients with contact dermatitis from Parthenium hysterophorus. Coexisting renal calculus disease may pose technical challenges in the surgical management of ureteropelvic junction obstruction. Firstly, we establish the usefulness and suitability of X-ray photoelectron spectroscopy (XPS) for determination of surface chemical composition and scanning electron microscopy (SEM) for determining the structure of solid dispersions composed of different types of carriers, drugs and drug concentrations. The second component (4 - 5 h) of the oxLDL-induced EGFR activation is antioxidant-sensitive, since it is blocked by antioxidants such as trolox, caffeic acid or PDTC, which act by blocking the cellular oxidative stress (H(2)O(2) generation) evoked by oxLDL. Like radioactive waste, municipal solid waste (MSW) requires consideration of a complex mix of intergenerational and intragenerational risks surrounded by uncertain science. Furthermore, when co-expressed simultaneously in the same cell, the N-terminal and C-terminal caspase fragments associate to reconstitute O-GlcNAcase enzymatic activity.

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Effects of the length of central cancer registry operations on identification of subsequent cancers and on survival estimates. The EMA was restrictive to grant a shorten review time status for products with therapeutic interest during the study period. Preparation and properties of the internal capsid components of reovirus. Hereditary non-polyposis colorectal cancer or Lynch syndrome is an autosomal dominantly inherited disease with high penetrance, mostly due to mutations in the MLH1 and MSH2 genes. Exploring the Relationship between Reward and Punishment Sensitivity and Gambling Disorder in a Clinical Sample: A Path Modeling Analysis. Tumours of the lacrimal gland may present with swelling of the lacrimal gland, displacement of the eyeball, reduced eye motility and diplopia. Bilateral ovarian metastasis of cervical squamous cell carcinoma in a young patient: a rare entity. Observations and considerations on the morphology and mechanism of trigonum fibrosum of the heart. In early development much of the cellular diversity and pattern formation of the embryo is believed to be set up by morphogens. Facing a Clever Predator Demands Clever Responses - Red-Backed Shrikes (Lanius collurio) vs.

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A bivalent vaccine to protect against Streptococcus pneumoniae and Salmonella typhi. In summary, our results demonstrate flexibility in PBS and primer usage for SIVmac239, with PBS-primer complementarity being the major determinant, in analogy with previous findings for murine leukemia viruses and human immunodeficiency virus type 1. FIBROSARCOMA WITHIN A SINUS TRACT OF CHRONIC DRAINING OSTEOMYELITIS. Positron emission tomographic study of affective disorders: prometrium 200 mg side effects during pregnancy problems and strategies. Transient apical ballooning syndrome--clinical characteristics, ballooning pattern, and long-term follow-up in a Swiss population.

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In this study, frequency spectra of friction force and friction induced vibration signals were carried out to investigate tactile perception by an artificial finger sliding on skin. Intermittent fluid drip suggests misplacement of central venous catheter into the interpleural space. After MRI and ultrasonography of 10 cadaveric foot specimens, the thickness of the central and lateral portions of the plantar aponeurosis displayed by imaging studies was measured by three radiologists. MRI and MRA may be helpful in the diagnosis of cerebellar infarction and vertebral artery abnormality. The response of hospitals to demographic, social and morbidity changes in society. Preparation, characterization and biodistribution in quails of 99mTc-folic acid/chitosan nanostructure. ALCOHOL CONSUMPTION IN PRAIRIEVILLE: EFFECT OF CHANGE IN TYPE OF OUTLET ON DRINKING IN A SMALL TOWN. Recognition of the efficacy of relaxation program on sleep quality of mothers with premature infants. Skeletal muscle mitochondrial density, gene expression, and enzyme activities in human heart failure: minimal effects of the disease and resistance training.

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Enhancement of methacholine-evoked tracheal contraction induced by bacterial lipopolysaccharides depends on epithelium and tumor necrosis factor. Polyphloroglucinol phosphate, a new synthetic enzyme inhibitor in local therapy of burns. RESEARCH ON BILIARY CALCULOSIS INDUCED BY CHOLESTANOL IN RABBITS. 14-3-3 proteins are a highly conserved family of cytoplasmic proteins that maximum dose of glyburide per day associate with several intracellular signaling molecules in regulation of various cellular functions. Michael addition reactions between chiral Ni(II) complex of glycine and 3-(trans-enoyl)oxazolidin-2-ones. are often found on dead vegetation, in soil, air and dust, but also on food and feedstuffs and on water-damaged building materials. Boldine is one of the most potent natural antioxidants and displays some important pharmacological activities, such as cytoprotective and anti-inflammatory activities, which may arise from its free radical scavenging properties. These results were used to segment the monkey and rat striata according to ACC/OFC inputs.

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There may be application for NSAIDs for myocardial infarction in humans. Therefore, Dpl is unlikely to exert a cell-autonomous function during neural differentiation and, in contrast to its homologue PrPC, is dispensable for prion disease progression and for generation of PrPSc. The effect of structural inhomogeneities in the coupling term on the observed network state is quantified by examining the relation between simulated and empirical functional connectivity. Enoxaparin 60-mg every 12 h was superior to a dosage of 40 mg every 12 h in achieving therapeutic anti-Xa concentrations and avoiding subtherapeutic anti-Xa levels. Thus skipping appears to be a stronger cardiorespiratory training stimulus than jogging for a given pace, but a less enjoyable activity. Rebuilding of binocular vision after strabismus surgeries for thyroid-associated ophthalmopathy. In contrast to mesenchymal and griseofulvin dosage tinea capitis myxoid types, the prognosis of classic variants is usually good and does not require adjuvant treatment modalities if a radical resection of the tumor can be obtained. Changes in expression of 324 genes previously correlated with cell motility were observed. Obliteration of the tract after conjunctivodacryocystorhinostomy is one of the main complications associated with the procedure.

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Evaluation of severity of toxic hepatitis in acute poisoning with chlorinated hydrocarbons after changes of the activity of aminotransferases and sorbitol dehydrogenase. Successful control of vancomycin-resistant Enterococcus faecium outbreak in a neurosurgical unit at non-endemic region. Patients who have undergone intracoronary stent implantation often require surgery within the first year after the procedure. In lung transplantation, gDSA appears to be a valuable biomarker to identify pathogenic DSA and LTRs with a higher risk for graft loss. The patients had no diabetes mellitus and no arterial hypertension. THE CLINICAL AND PHYSIOLOGICAL DIFFERENTIATION OF CHRONIC BRONCHITIS AND EMPHYSEMA. These observations imply a possible key function for the intrinsic cellular inhibitor XIAP in maintaining the homeostasis of the immune system.

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Large cell neuroendocrine cancer of the cervix is a rare entity. The need for magnesium increases during pregnancy, and the majority of pregnant women likely do not meet this increased need. P-gp may be physiologically involved in an important part of the transporter system, not only in the acinar serous cells and the striated duct cells, but also in the excretory duct cells in the salivary glands. The perception of self is an important topic in several disciplines such as ethology, behavioral ecology, psychology, developmental and cognitive neuroscience. Effects of thoracotomy on volume conductor properties of the canine torso. Multidisciplinary cooperation in health care requires a solid knowledge in the basic sciences for a common ground of communication. These results suggest that the sensitivity of igf-1 and igfbp-1s to fasting differs between tissues and subtypes, respectively. Extracorporeal shock wave lithotripsy is also a highly effective method of treatment for urolithiasis in children. The unidirectional theory focuses on correspondences between speech and writing while the multidirectional theory directs attention to the differences as well as the similarities between speech and writing.

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