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Xeloda (Capecitabine)
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Xeloda

Xeloda is used in the treatment of cancer of breast, colon, and rectum. It may be also used to treat other conditions, as determined by the doctor. It is used alone or in combination with some other medicine as a part of chemotherapy.

Other names for this medication:
Capecitabine, Capegard, Capehope, Capget, Capiibine, Capres, Capscare, Captabin, Capxcel, Distamine, Naprocap, Xabine, Xelocel

Similar Products:
Precose, Bystolic, Symmetrel, Skelaxin, Ultram, Xanax, Daklinza, Endogest, Amlonol, Turimycin, Metoclop, Typteez, Larizin, Aygestin,

Also known as: Capecitabine

Description

Xeloda (capecitabine) is a cancer medicine that interferes with the growth of cancer cells and slows their spread in the body.

Xeloda is used alone or in combination chemotherapy to treat colon cancer, breast cancer, or colorectal cancer.

Xeloda is sometimes used when cancer has spread to other parts of the body (metastatic).

Dosage

Usual Adult Dose of Xeloda for Colorectal Cancer:

MONOTHERAPY: For first line treatment of patients with metastatic colorectal carcinoma when treatment with fluoropyrimidine therapy alone is preferred: -RECOMMENDED DOSE: 1250 mg/m2 orally 2 times a day (morning and evening; equivalent to 2500 mg/m2 total daily dose) for 2 weeks followed by a 1 week rest period given as 3 week cycles ADJUVANT TREATMENT IN PATIENTS WITH DUKES' C COLON CANCER: -RECOMMENDED DOSE: 1250 mg/m2 orally 2 times a day (morning and evening; equivalent to 2500 mg/m2 total daily dose) for 2 weeks followed by a 1 week rest period given as 3 week cycles for a total of 8 cycles (24 weeks) Comments: -The tablets should be swallowed whole with water within 30 minutes after a meal. Use: Colorectal Cancer: -As monotherapy for adjuvant treatment in patients with Dukes' C colon cancer who have undergone complete resection of the primary tumor when treatment with fluoropyrimidine therapy alone is preferred; this drug was non-inferior to 5-fluorouracil and leucovorin (5-FU/LV) for disease-free survival (DFS); physicians should consider results of combination chemotherapy trials, which have shown improvement in DFS and OS, when prescribing this drug as a single-agent in the adjuvant treatment of Dukes' C colon cancer -As first-line treatment of patients with metastatic colorectal carcinoma when treatment with fluoropyrimidine therapy alone is preferred; combination chemotherapy has shown a survival benefit compared to 5-FU/LV alone; survival benefit over 5-FU/LV has not been demonstrated with this drug as monotherapy; use of this drug instead of 5-FU/LV in combinations has not been adequately studied to assure safety or preservation of the survival advantage

Usual Adult Dose of Xeloda for Breast Cancer:

MONOTHERAPY: -RECOMMENDED DOSE: 1250 mg/m2 orally 2 times a day (morning and evening; equivalent to 2500 mg/m2 total daily dose) for 2 weeks followed by a 1 week rest period combined with docetaxel 75 mg/m2 as a 1 hour IV infusion, every 3 weeks IN COMBINATION WITH DOCETAXEL: -RECOMMENDED DOSE: 1250 mg/m2 orally 2 times a day (morning and evening; equivalent to 2500 mg/m2 total daily dose) for 2 weeks followed by a 1 week rest period given as 3 week cycles Comments: -The manufacturer prescribing information for docetaxel should be consulted for premedication advice. -The tablets should be swallowed whole with water within 30 minutes after a meal. Use: Breast Cancer: -In combination with docetaxel for the treatment of patients with metastatic breast cancer after failure of prior anthracycline-containing chemotherapy -As monotherapy for the treatment of patients with metastatic breast cancer resistant to both paclitaxel and an anthracycline-containing chemotherapy regimen or resistant to paclitaxel and for whom further anthracycline therapy is not indicated (e.g., patients who have received cumulative doses of 400 mg/m2 of doxorubicin or doxorubicin equivalents); resistance is defined as progressive disease while on treatment, with or without an initial response, or relapse within 6 months of completing treatment with an anthracycline-containing adjuvant regimen

Detailed Xeloda dosage information

Overdose

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Storage

Store at room temperature below 30 degrees C (86 degrees F) away from moisture and heat. Do not store it in the bathroom or near a sink. Do not leave it in the car or on window sills. Keep out of the reach of children in a container that small children cannot open.

Side effects

The most common side effects associated with Xeloda are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

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Their demographic data, DSM-IV diagnosis and help-seeking patterns were assessed by a self-report questionnaire and the CB-SCID (Chinese-bilingual Structured Clinical Interview Schedule for the DSM-IV). Determinants of effective cooling during endovascular hypothermia. TREATMENT OF PUERPERAL MAMMARY COMPLICATIONS WITH TRICHLOROMETHIAZIDE. A prominent accelerating decrease with age was also observed, the longitudinal decrement becoming more marked with advancing age. Pet1-Cre-driven deletion of HDAC6 in serotonin neurons, the densest HDAC6-expressing cell group in the mouse brain, dramatically reduced acute anxiogenic effects of the glucocorticoid hormone corticosterone in the open-field, elevated plus maze, and social interaction tests. Gas chromatography/isotope ratio mass spectrometry of recalcitrant target compounds: performance of different combustion reactors and strategies for standardization. The role of perceived parental rearing practices in the aetiology of phobic disorders: a controlled study. To evaluate the relevance of the so called risk factors for osteoporosis among women. Self-assembly behavior of A-B diblock and C-D random copolymer mixtures in the solution state through mediated hydrogen bonding. The Neer test, Speed test, acromioclavicular shear test, Rowe test, and palpation for point tenderness.

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Patients with recurrent stone disease need careful evaluation for underlying metabolic disorder. In this work, latest reports about metal toxicity, transport and homeostasis have been thoroughly described and discussed. These small molecules have been found to regulate genes involved in diverse biological processes such as cell proliferation, development, differentiation, apoptosis and others. Measurement of the intestinal permeability in chronic kidney disease. Our findings emphasize the potential importance of interaction with the sugar-phosphate polynucleotide backbone in binding of the fd gene 5 protein to nucleic acids. In vitro stability and expression of green fluorescent protein under high pressure conditions. Spectrum of Reactivity with Three Monoclonal Antibodies-MHM6(CD23), L30(CD24) and UCHB1-in B-Cell Leukaemias. Lower glucagon levels of cord blood were seen in premature infants with higher GA, which might contribute to the occurrence of postnatal hypoglycemia. FAILURE TO THRIVE AND SHORT STATURE ASSOCIATED WITH XXY-CHROMOSOMAL PATTERN.

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Are patients with positive screening but negative diagnostic test for gestational diabetes under risk for adverse pregnancy outcome?. Clinical and EEG manifestations of an unusual aphasic syndrome in children. Studies on anaphylactic reactions on the isolated intestines of guinea pigs. Survey on failures in reporting acute infectious diseases in Gulo District, Nanjing City in 1981. It is shown that when the propagation channel is not completely known, as is the case of the experimental data, the novel detector outperforms the others in terms of threshold signal-to-noise ratio (SNR).

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The protective effect of Shenfu injection against elderly severe pneumonia. But it can be recommended for screening in patients without history of bladder cancer but with an increased risk (smokers, patients with dysuria and hematuria). Lipid based delivery and immuno-stimulatory systems: Master tools to combat leishmaniasis. We recommend that both the above nucleosides be added to the list of antiretroviral drugs that can induce Fanconi syndrome and that patients on stavudine and lamivudine be monitored carefully for early signs of Fanconi syndrome. The seven member, human MORF4 related gene (MRG) family was recently identified based on the ability of Mortality factor on chromosome 4 (MORF4) to induce replicative senescence in immortal cell lines assigned to complementation group B (Bertram et al., 1999. The development and anatomy of Diphyllobothrium dendriticum Nitzsch 1824. Discounting and per diem arrangements lock in patient referrals. Dentition status and treatment needs among children with impaired hearing attending a special school for the deaf and mute in Udaipur, India. Two hundred fifteen patients with newly diagnosed essential hypertension underwent 24-hour ambulatory blood pressure monitoring, biochemistry analysis and 24-hour urine testing. The former induced both quantitative and qualitative alterations in the cyclic sleep organization, the latter did not show significant alterations in this organization but rather in transition between adalat 20 mg sleeping and waking and in sleep maintenance.

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The Spiritual Distress Assessment Tool (SDAT) is a 5-item instrument developed to assess unmet spiritual needs in hospitalized elderly patients and to determine the presence of spiritual distress. This suggests that future research must focus more narrowly on conditions under which legitimacy are generated in order to expand the understanding of public involvement in health prioritization. These results show that the correlation length of a polymer blend constrains polymer diffusion, as suggested from previous neutron scattering measurements, and mean-field theory. A 29-year-old male professional handball player presented with anterior knee pain that persisted after 4 months of an eccentric rehabilitation protocol and platelet-rich plasma injections. Finally, simulation results verify that our proposed analytical framework is reasonable and can provide the reference for executing the optimal spectrum handoff strategy and designing the admission control rule for the SU in cognitive radio networks. Host-plasmid interactions were studied for the broad-host range plasmid, pTJS26, a derivative of RK2. It will require an environment of effective collaboration amongst multiple stakeholders including consumers. This paper examines factors governing urine flow in a stented ureter, the implications for reflux, and the processes by which the stent surface encrusts, in particular focusing on the influence of bacterial infection. Opinions about plasma exchange and associated treatments in the therapy of myasthenia gravis. The model also reproduces the observed biphasic kinetics of plasmid number instability. side effects of xanax drug

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Thrombomodulin: a bifunctional modulator of inflammation and coagulation in sepsis. To determine the role of diffusion tensor imaging (DTI) metrics as biomarkers for the therapeutic effects of mesenchymal stem cells (MSCs) in acute peripheral nerve injury. Finally, I argue against the assertion that such usage degrades the concept of the operant, at least in any meaningful way, and argue instead that employing eccentric definitions for ordinary words and using arcane terms to describe everyday human behavior risks diminishing the influence of behavior analysis on human affairs. ASE is a fully automated and reliable extraction technique with many advantages over traditional extraction techniques, so it could be especially useful for routine analyses of pollutants in food and feed. The isolated N-terminal peptide modified N-terminally with TMPP-Ac-OSu reagent produces a simple fragmentation pattern under tandem mass spectrometric analysis to significantly facilitate sequencing. Corticotropin releasing factor (CRF)-immunoreactive neurons were detected in the paraventricular nuclei (PVN) of the rat brain, using both the traditional and the recently developed silver-gold intensified PAP methods at light and electron microscopic levels. Delayed Development of Extrathoracic Lung Herniation after Blunt Thoracic mometasone furoate monohydrate nasal spray dosage Trauma. Expression of the SCAMP-4 gene, a new member of the secretory carrier membrane protein family, is repressed by progesterone in brain regions associated with female sexual behavior. IN administration of midazolam gel was superior to both IN and rectal administration of midazolam solution with respect to peak plasma concentration and bioavailability. This product has been tentatively identified as an indole derivative.

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