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Viagra

Viagra is a medication used to treat erectile dysfunction and pulmonary arterial hypertension. Its effectiveness for treating sexual dysfunction in women has not been demonstrated. Pfizer scientists Andrew Bell, David Brown, and Nicholas Terrett originally discovered sildenafil as a treatment for various cardiovascular disorders. Since becoming available in 1998, sildenafil has been a common treatment for erectile dysfunction The primary indication of sildenafil is treatment of erectile dysfunction (inability to sustain a satisfactory erection to complete intercourse). Its use is now one of the standard treatments for erectile dysfunction, including for men with diabetes mellitus.

Other names for this medication:
Caverta, Intagra, Kamagra, Penegra, Revatio, Silagra, Sildenafil, Sildenafila, Sildenafilo, Sildenafilum, Sildigra, Suhagra, Veega, Zenegra

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Also known as: Sildenafil

Description

Viagra is approved to treat erectile dysfunction (ED) in men. With ED, you have trouble getting and keeping an erection that’s firm enough to allow you to have sex.

What causes an erection?

When you’re sexually aroused, either through sexual thoughts or touch, your brain sends messages to your penis. These messages cause certain chemicals to be released in your penis.

One of these chemicals, called cyclic GMP, relaxes and widens certain blood vessels in your penis. Cyclic GMP also relaxes the muscles around the erectile tissue in your penis that’s called the corpus cavernosum. These actions allow blood to flow into the corpus cavernosum, which causes your penis to get hard and become erect.

What happens with ED?

ED can occur if you have certain problems that affect your body’s ability to have an erection. The condition can result from problems with messages being sent from your brain. ED can also result from problems with blood flow into your penis.

What does Viagra do for ED?

Viagra works to treat ED by helping you have and maintain an erection. The drug does this by improving blood flow into your penis when you’re sexually aroused.

Viagra is a type of drug called a phosphodiesterase type 5 (PDE5) inhibitor. It works by inhibiting (blocking) the action of an enzyme called PDE5. (An enzyme is a protein that helps chemical reactions to happen inside your body.)

Normally, an erection goes away when PDE5 breaks down the cyclic GMP in your penis. But Viagra blocks the action of PDE5, so it allows cyclic GMP to keep working for a longer period of time than usual. This action improves blood flow to your penis and helps you to have and keep an erection.

Does Viagra increase a man’s sex drive?

No, Viagra doesn’t directly increase your sex drive. And it doesn’t make you sexually aroused. However, some men find that if Viagra works to treat their erectile problem, it also increases their sexual confidence. And this may lead to an increased sex drive.

How can I tell if Viagra’s not working?

Viagra may not work for everyone, and it may not work every time you take it.

If you’re sexually aroused, Viagra should work to help you have or keep an erection within 30 minutes to 2 hours. But if you don’t get an erection within 4 hours after taking a dose, Viagra didn’t work for you this time.

If the drug doesn’t work for you, you shouldn’t take another dose until at least 24 hours later. And talk with your doctor if you feel Viagra isn’t helping to treat your ED. They may recommend that you try a different medication for your ED.

How can I get Viagra to work?

It’s important to remember that Viagra only works if you’re already sexually aroused. Arousal may involve having sexual thoughts, looking at sexual images, masturbating, or engaging in foreplay.

But if you feel anxious, nervous, depressed, or stressed, your body may not respond well to sexual stimulation. If this is the case, try to relax, make yourself comfortable, and take your time. In addition, it’s best to avoid drinking a lot of alcohol. This is because consuming large amounts of alcohol can make it more difficult for you to get an erection.

If you’re having trouble getting an erection, even while using Viagra, talk with your doctor.

Is Viagra a blood thinner?

No, Viagra isn’t a blood thinner. Instead, it belongs to a class of drugs called phosphodiesterase type 5 (PDE5) inhibitors. (A class of drugs describes a group of medications that work in a similar way.) Viagra works by inhibiting (blocking) the action of a certain enzyme in your body.

Since Viagra has been released onto the market, there have been a few reports of bleeding in people who’ve taken the drug. However, there’s no evidence that Viagra caused these bleeding problems.

It’s not known if Viagra is safe for use by people with a bleeding problem. If you have any bleeding problems, talk with your doctor about whether Viagra is safe for you.

Dosage

Sildenafil's popularity with young adults has increased over the years. Sildenafil's trade name, Viagra, is widely recognized in popular culture, and the drug's association with treating erectile dysfunction has led to its recreational use. The reasons behind such use include the belief that the drug increases libido, improves sexual performance, or permanently increases penis size. Studies on the effects of viagra when used recreationally are limited, but suggest it has little effect when used by those not suffering from erectile dysfunction. In one study, a 25-mg dose was shown to cause no significant change in erectile quality, but did reduce the postejaculatory refractory time. This study also noted a significant placebo effect in the control group.

Unprescribed recreational use of sildenafil and other PDE5 inhibitors is noted as particularly high among users of illegal drugs. Sildenafil is sometimes used to counteract the effects of other substances, often illicit. Some users mix it with methylenedioxymethamphetamine (MDMA, ecstasy), other stimulants, or opiates in an attempt to compensate for the common side effect of erectile dysfunction, a combination known as "sextasy", "rockin' and rollin'" or "trail mix". Mixing with amyl nitrite is particularly dangerous and potentially fatal.

Overdose

If you take an overdose of Viagra, you should seek emergency medical attention or contact your healthcare provider immediately.

Storage

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture and heat. Throw away any unused medicine after the expiration date. Keep out of reach of children.

Side effects

The most common side effects associated with Viagra are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Below are the cases in which Viagra is contraindicated in men:

Individuals below 18 years of age - sildenafil cannot be consumed by male persons below 18 years of age until your Doctor prescribes.

Retinal disorders - sildenafil cannot be consumed in case of rare hereditary disorders which includes non-arteritic anterior ischaemic optic neuropathy (NAION). Sildenafil is also contraindicated in cases of retinal disorder.

This list of contraindications is not exhaustive. Ask your Doctor or pharmacist for more information related contraindications of sildenafil.

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Motor impairment evaluation for upper limb in stroke patients on the basis of a microsensor. The observations that pepT1 was highly expressed in human colorectal tumor and that its overexpression and deletion in mice increased and decreased colitis associated tumorigenesis, respectively, suggest that PepT1 is a potential therapeutic target for the treatment of colitis associated tumorigenesis. Mechanism of interconversion among radiation-induced defects in amorphous silicon dioxide. Antimicrobial susceptibility of Actinobacillus pleuropneumoniae isolated from pigs in Korea using new standardized procedures. We hypothesized that patients with Hunt-Hess (HH) grade IV-V may not benefit from aggressive measures. Contribution of Iran to the Ophthalmic Literature over the Past Three Decades. No correlation was observed between the surface electrical charge on algae and their phagocytosis by host endodermal cells. It is found that solitons are allowed in the supersonic regime, and that in dense clouds the width of the Mach number range remains finite for the Boltzmann ions, but tends to zero for highly energetic ions. Herein we present a case of a patient who sustained proximal humerus fracture associated with axillary artery rupture and acute renal failure due to rhabdomyolysis. Increase in platelet count in response to rHuEpo in a patient with thrombocytopenia and absent radii syndrome.

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EXTRATHYROID DISTRIBUTION OF I-131 IN THE SEA FROG (RANA RIDIBUNDA PALL.). In many countries, most of the genetic counselling is provided by genetic counsellors who have a specialised post-graduate training. Isoflavone attenuates vascular contraction through inhibition of the RhoA/Rho-kinase signaling pathway. We show that protein vulnerability quantifies dosage sensitivity for metabolic adaptation phases and tissue-specific patterns of mRNA expression, determining the extent of co-expression similarity of binding partners. When those with perceived needs for care were considered in isolation, there was no difference between birthplace groups in terms of their likelihood of reporting that their needs were fully met. Ascl1 (Mash1) lineage cells contribute to discrete cell populations in CNS architecture. Differences between the conformations of nitrotyrosyl-248 carboxypeptidase A in the crystalline state and in solution. A review of transfusion practice before, during, and after hematopoietic progenitor cell transplantation. BRAIN-STIMULATION INTENSITY, RATE OF SELF-STIMULATION, AND REINFORCEMENT STRENGTH: AN ANALYSIS THROUGH CHAINING. The findings are based on observations of two infected patients (the case history of one was reported previously) and on reports in the literature of 32 others.

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