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Prograf (Tacrolimus)

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Prograf works on the immune system to prevent rejection of an organ transplant and is usually taken in combination with other anti-rejection medications. Swallow the capsules and tablets whole. Don’t cut, crush, or chew them.

Other names for this medication:
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Also known as: Tacrolimus


Prograf (tacrolimus) weakens your body's immune system, to help keep it from "rejecting" a transplanted organ such as a kidney. Organ rejection happens when the immune system treats the new organ as an invader and attacks it.

Prograf is a prescription medicine and is used together with other medicines to prevent your body from rejecting a heart, liver, lung, or kidney transplant.

Prograf is supplied as oral capsules, granules for oral suspension, and as an injection for intravenous use.

Prograf capsules and oral granules are immediate-release medicines and they are not the same as tacrolimus extended-release tablets or tacrolimus extended-release capsules. Your healthcare provider should decide what medicine is right for you.


Take Prograf exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose.

You may receive an injection of Prograf shortly after your transplant. The injection is given until you are ready to take the pill form of tacrolimus.

Take Prograf at the same time each day, with a full glass of water.

Swallow the capsule whole and do not crush, chew, break, or open it.

Mix Prograf oral granules with water right before you take them. Do not save this mixture for later use. Do not get the powder or mixture on your skin or in your eyes. If this happens, wash your skin with soap and water or rinse your eyes with water.

You may take Prograf with or without food, but take it the same way each time.

Your dose needs may change if you switch to a different brand, strength, or form of this medicine. All forms of tacrolimus are not equivalent and may not have the same dose or schedule. Avoid medication errors by using only the form and strength your doctor prescribes.

You will need frequent medical tests, and your blood pressure will need to be checked often.

Store at room temperature away from moisture and heat.

Detailed Prograf dosage information


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.


Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Prograf are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Do not use Generic Prograf if you are allergic to Generic Prograf components. Do not use Generic Prograf while you are pregnant or have nurseling. Do not take Generic Prograf if you use cyclosporine (such as Gengraf, Neoral, Sandimmune). Try to be careful with Generic Prograf usage in case of taking bromocriptine (Parlodel), carbamazepine (Tegretol), cimetidine (Tagamet), cisapride (Propulsid), clarithromycin (Biaxin), clotrimazole (Mycelex, Lotrimin), danazol (Danocrine), diltiazem (Cardizem), erythromycin (E-Mycin), fluconazole (Diflucan), ganciclovir (Cytovene), HIV protease inhibitors such as indinavir (Crixivan) and ritonavir (Norvir), itraconazole (Sporanox), ketoconazole (Nizoral), methylprednisolone (Medrol), metoclopramide (Reglan), nefazodone (Serzone), nicardipine (Cardene), nifedipine (Adalat, Procardia), omeprazole (Prilosec), phenobarbital, phenytoin (Dilantin), rifabutin (Mycobutin), rifampin (Rifadin, Rimactane), spironolactone (Aldactone), triamterene-containing drugs (Dyazide, Dyrenium, Maxzide), troleandomycin (Tao), verapamil (Calan, Isoptin), and vitamins, amiloride (Midamor, Moduretic), cyclosporine (Neoral, Sandimmune), oral contraceptives (birth control pills). Try to be careful with Generic Prograf if you suffer from or have a history of kidney or liver disease, diabetes, high blood pressure. Avoid ill people. Avoid grapefruit or grapefruit juice. Protect your skin from the sun. Avoid vaccinations. Be careful with Generic Prograf if you are going to have a surgery. Avoid alcohol. It can be dangerous to stop Generic Prograf taking suddenly.

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