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Phenergan (Promethazine)

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Phenergan is an inexpensive drug used to treat allergic reactions and to treat or prevent nausea and vomiting from illness. It is also used to help treat pain or nausea after surgery.

Other names for this medication:
Abrozin, Aceegan, Basiprom, Biodol, Calmkid, Cofcodyl, Emispan, Ethamol, Febrinil, Kelvin, Kidkof, Kosgan, Lagesic, Lincotuss, Metacet, Nimkair, Paracee, Parapro, Petrox, Phenazine, Phenomet, Pinex, Pizol, Promit, Promyoz, Propar, Prosed, Prosip, Prosym, Pyrivin, Romet, Symol, Synergan, Tixylix, Tussdex

Similar Products:
Cialis, Prandin, Estrace, Aldara, Yasmin, Glucophage, Fosamax, Predom, Odivir, Valaplex, Glyfix, Amiodarone, Amitryptyline, Velax,

Also known as: Promethazine


Promethazine is in a group of drugs called phenothiazines (FEEN-oh-THYE-a-zeens). It works by changing the actions of chemicals in your brain.

Promethazine is used to treat or prevent nausea and vomiting caused by anesthesia or surgery, certain types of allergic reactions, pain caused by surgery or childbirth, and to sedate patients before surgery or medical procedures.

Promethazine injection is usually given when a person cannot take the medication orally (by mouth).


This section provides information on the proper use of a number of products that contain promethazine. It may not be specific to Phenergan. Please read with care.

Never take rectal suppositories by mouth.

Wash your hands with soap and water before and after using this medicine.

To insert suppository: First remove the foil wrapper and moisten the suppository with cold water. Lie down on your side and use your finger to push the suppository well up into the rectum. If the suppository is too soft to insert, chill the suppository in the refrigerator for 30 minutes or run cold water over it before removing the foil wrapper.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For rectal dosage form (suppositories): For allergy symptoms: Adults and teenagers—12.5 milligrams (mg) before meals and at bedtime; or 25 mg at bedtime as needed. Children 2 years of age and older—Your doctor will determine dose based on the weight and/or size of the child. The dose is usually 6.25 to 12.5 mg three times a day; or 25 mg at bedtime as needed. Children younger than 2 years of age—Use and dose must be determined by your doctor . For prevention of motion sickness: Adults and teenagers—25 mg twice daily; this initial dose should be taken one-half to one hour before traveling. The dose may be repeated eight to twelve hours later if needed. On other days of travel, 25 mg may be taken on arising and again before the evening meal. Children 2 years of age and older—Your doctor will determine dose based on the weight and/or size of the child. The dose is usually 12.5 to 25 mg one-half to one hour before traveling. The dose may be repeated eight to twelve hours later if needed. Children younger than 2 years of age—Use and dose must be determined by your doctor . For nausea and vomiting: Adults and teenagers—25 mg for the first dose, then 12.5 to 25 mg every four to six hours if needed. Children 2 years of age and older—Your doctor will determine dose based on the weight and/or size of the child. The dose is usually 0.5 mg per pound of body weight (1.1 mg per kg) or 12.5 to 25 mg every four to six hours as needed. Children younger than 2 years of age—Use and dose must be determined by your doctor . For sedation: Adults and teenagers—25 to 50 mg. Children 2 years of age and older—Your doctor will determine dose based on the weight and/or size of the child. The dose is usually 12.5 to 25 mg. Children younger than 2 years of age—Use and dose must be determined by your doctor . For control of pain or anxiety before or after surgery: Adults and teenagers—50 mg the night before surgery; 25 to 50 mg after surgery. Children 2 years of age and older—Your doctor will determine dose based on the weight and/or size of the child. The dose is usually 0.5 mg per pound of body weight (1.1 mg per kg) or 12.5 to 25 mg the night before surgery or after the surgery. Children younger than 2 years of age—Use and dose must be determined by your doctor .


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include overactive reflexes, loss of coordination, severe drowsiness or weakness, fainting, dilated pupils, weak or shallow breathing, or seizure (convulsions).


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Do not keep outdated medicine or medicine no longer needed.

Keep out of the reach of children.

Detailed Phenergan dosage information

Side effects

The most common side effects associated with Phenergan are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Do not take Phenergan if you are allergic to Promethazine or any ingredients comprised in this medication. Do not take Phenergan if you suffer from epilepsy, have difficulty breathing, wheezing, tightness in the chest (asthma) or an infection in your lungs (bronchitis), serious heart problems, liver or kidney problems, a stomach blockage or difficulty passing water, hearing problems, narrow-angle glaucoma, Reye’s Syndrome or signs of Reye’s Syndrome. Do not take Phenergan in person is unconscious (in a coma) or suffers from severe dizziness, drowsiness or headache. Do not combine Phenergan with oral drugs for diabetes, drugs to treat sleeplessness or anxiety, other antihistamines to treat allergic reactions, drugs for depression called a monoamine oxidase inhibitor (MAOI), aspirin (for arthritis and pain in your joints), drugs to help you to sleep or feel more relaxed (such as diazepam or zolpidem), anticholinergic drugs. Do not drink alcohol when you are taking Phenergan. Do not take Phenergan if you are pregnant unless prescribed, plan to have a baby or are breastfeeding. Phenergan is not for use in children under 5 years of age.

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