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Nuvigil (Armodafinil)

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Nuvigil is currently FDA-approved to treat excessive daytime sleepiness associated with obstructive sleep apnea, narcolepsy, and shift work disorder. It is commonly used off-label to treat attention deficit hyperactivity disorder, chronic fatigue syndrome, and major depressive disorder. It has been shown to improve vigilance in air traffic controllers. Nuvigil is approved by the U.S. FDA for the treatment of narcolepsy and shift work sleep disorder, and as an adjuvant therapy for obstructive sleep apnea.For narcolepsy and obstructive sleep apnea, Nuvigil is taken as a once daily 150 mg or 250 mg dose in the morning. For shift work sleep disorder, 150 mg of Nuvigil are taken one hour prior to starting work. Slow dose titration is needed to mitigate some side effects.

Other names for this medication:
Armod, Armodafinil, Biryth, Waklert

Similar Products:
Pepcid, Nuvigil, Persantine, Altace, Valtrex, Flomax, Flagyl, Glucobay, Rulid, Pantex, Etinact, Invasc, Glyrim, Orawis, Venexor,

Also known as: Armodafinil


Nuvigil (armodafinil) is a medication that promotes wakefulness.

Nuvigil is used to treat excessive sleepiness caused by sleep apnea, narcolepsy, or shift work sleep disorder.


Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.

This medication comes with patient instructions for safe and effective use. Follow these directions carefully. Ask your doctor or pharmacist if you have any questions.

Nuvigil is usually given for up to 12 weeks. Follow your doctor's instructions.

Nuvigil is usually taken each morning to prevent daytime sleepiness, or 1 hour before the start of a work shift to treat work-time sleep disorders.

If you are taking Nuvigil to treat sleepiness caused by obstructive sleep apnea, you may also be treated with a continuous positive airway pressure (CPAP) machine. This machine is an air pump connected to mask that gently blows pressurized air into your nose while you sleep. The pump does not breathe for you, but the gentle force of air helps keep your airway open to prevent obstruction.

Do not stop using your CPAP machine during sleep unless your doctor tells you to. The combination of treatment with CPAP and Nuvigil may be necessary to best treat your condition.

Nuvigil will not cure obstructive sleep apnea or treat its underlying causes. Follow your doctor's instructions about all your other treatments for this disorder.

Taking this medication does not take the place of getting enough sleep. Talk with your doctor if you continue to have excessive sleepiness even while taking Nuvigil.


When a person takes too much Nuvigil, overdose symptoms may include unusual bruising or bleeding, nausea, diarrhea, and chest pain. Specific effects will be based on certain factors. If the Nuvigil overdose was recent, healthcare providers may give certain medicines, place a tube in the stomach to pump the stomach, or treat the symptoms that occur as a result of the overdose.


Store Nuvigil at 20 to 25 deegres C (68 to 77 degrees F).

Keep this and all medicines out of the reach of children.

Nuvigil is classified as federally controlled substance (C-IV), because it can be abused or lead to dependence. Keep Nuvigil in a safe place to prevent misuse and abuse.

Side effects

The most common side effects associated with Nuvigil are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


You should not use Nuvigil if you are allergic to armodafinil or modafinil (Provigil).

To make sure Nuvigil is safe for you, tell your doctor if you have ever had:

liver or kidney disease; heart disease or a heart muscle or valve disorder such as mitral valve prolapse; high blood pressure, heart disease, or prior heart attack; mental illness or psychosis; or drug or alcohol addiction.

It is not known whether Nuvigil will harm an unborn baby. Nuvigil has been reported to be associated with growth restriction (small fetus) and miscarriage. Tell your doctor if you are pregnant or plan to become pregnant.

Use a barrier form of birth control (condom or diaphragm with spermicide). Hormonal contraception (birth control pills, injections, implants, skin patches, and vaginal rings) will not effectively prevent pregnancy while you are taking Nuvigil.

It is not known whether Nuvigil passes into breast milk or if it could affect the nursing baby. Tell your doctor if you are breast-feeding.

Nuvigil is not approved for use by anyone younger than 17 years old.

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Large-scale elimination of paediatric HIV infections appears feasible, although this goal has not yet been fully achieved in KwaZulu-Natal. Therefore, understanding the mechanisms by which reporter enzyme activity can be modulated by small molecules is critical to the interpretation of HTS data. Retinoic acid contributes to the compensatory growth of the residual lung tissue. Knowledge exchange, peer-to-peer communication, and decision support, key factors in this success, will be applied in implementing the antimicrobial stewardship program throughout the hospital. Results of these simulations were then used to develop fitted logarithmic functions (extrapolated to 0.0 MeV) to correlate an estimated factor to any monoenergetic photon energy up to 3.0 MeV. Ertapenem-induced reduction in valproate levels: case report and review of the literature. The lymphotropic papovavirus (LPV)-specific mRNAs were translated in vitro in rabbit reticulocyte lysates. In testing these hypotheses, changes in receptor sensitivity or function have to be considered since we have observed simultaneous tolerance and supersensitivity development in the same animal treated chronically with lisuride. Population-based studies indicate that low testosterone levels predict development of type 2 diabetes mellitus, metabolic syndrome, and survival. MATURATION OF THE ELECTROCORTICOGRAM AND BEHAVIOUR IN THE KITTEN AND GUINEA-PIG AND THE EFFECT OF SOME SYMPATHOMIMETIC AMINES.

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Problems in the postgraduate training of primary care physicians in the future. In an earlier study, typically developing bilingual Spanish/English-speaking children were noted to use overregularizations in an elicited production task, accept these forms in a grammaticality judgment task, and reject standard irregular forms (e.g., caught) at surprising rates in favor of the overregularization (P. While the optimal section thickness is tuned to the size of the lesion being detected, overall performance is more robust for thin section images compared to thicker images. cis-Diammine(pyridine)chloroplatinum(II), a monofunctional platinum(II) antitumor agent: Uptake, structure, function, and prospects. This case demonstrates the successful management of a complex and potentially lethal wound of the perineum with debridement, skin grafting and the VAC system. The program of the parameterized algorithm can be obtained by sending an email to the corresponding author. The results from the analysis of the course evaluations from FELASA category C compulsory courses in laboratory animal science at Uppsala University showed that the students realize that theoretical knowledge of the subject and practical skills are of great importance to the success of their future research involving animal experiments. It also indicates a need to investigate the contributing factors in a specific organization, to select interventions based on this knowledge and for multiple but related actions that will support one another.

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Small case series suggest tremor occurs frequently in IgM-monoclonal gammopathy of undetermined significance (IgM-MGUS) neuropathy. Fungi found in association with Histoplasma capsulatum in a naturally contaminated site in Clarksburg, Maryland, U.S.A. Exercise responses in pregnant sheep: oxygen consumption, uterine blood flow, and blood volume. Investing in African research training institutions creates sustainable capacity for Africa: the case of the University of the Witwatersrand School of Public Health masters programme in epidemiology and biostatistics. One of these is the specific adsorption of ions located in the Stern layer in combination with a Gouy-Chapman diffuse part of the double layer. 2-Anilino-3-Aroylquinolines as Potent Tubulin Polymerization Inhibitors. Fluorescence in situ hybridization (FISH) is a highly sensitive molecular genetic technique, which enables to detect break point cluster region--Abelson (BCR-ABL) complex and minimal residual disease in all Ph positive CML patients not only in metaphase but also in interphase cells. The transcription complex containing WT1/Sox11 was immunoprecipitated from embryonic kidney cells with Sox11 antibodies, suggesting their presence in the same complex. Finally, it was found that pups could actively curtail interbout intervals by emitting ultrasonic vocalizations. The half-life of dihydrocodeine in saliva was about twice that found in blood.

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Overall, hGEnCs metabolized ANG II at a significantly slower rate compared with podocytes, whereas the ANG I processing rate was comparable between glomerular cell types. Thus, loss of ATRX immunoexpression, shown for the first time in these tumors, along with immunopositivity for p53 and IDH1, indicates that these tumors are molecular astrocytomas, and their clinical behaviour is likely to recapitulate that of ATRX-mutant and IDH-mutant diffuse astrocytomas of the same grade. We believe that partial sternotomy approach may be useful in some cases of off-pump CABG. Maximum bronchodilatation was achieved by albuterol aerosol in 14 of 17 patients, and addition of oral therapy produced no further increase of flow rate in these patients. This paper describes the rationale and progress of a collaborative project in Kenya to train primary care and community health workers about mental health and integrate mental health into their routine work, Within a health systems strengthening approach. DIAGNOSTIC SIGNIFICANCE OF CHANGE IN THE REACTION OF METHYLENE BLUE DISCOLORATION IN THE TREATMENT OF LATE PREGNANCY TOXEMIAS. Spin echo and gradient echo images as well as three-dimensional MR angiograms were obtained to study the effects of flow, magnetic susceptibility, and radiofrequency-induced eddy currents. Further research is needed to orient professionals, mainly regarding the heparinization of catheters and the first dressing change after the access, with a view to standardizing conducts based on safe scientific evidence.

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Plant centromeres are generally composed of tandem arrays of simple repeats that form a complex chromosome locus where the kinetochore forms imodium daily dose and microtubules attach during mitosis and meiosis. First, we will generalise the theoretical results already obtained for attractive networks in one dimension to more complicated neural networks. Interleukin 2 (IL-2) is a T cell-derived lymphokine that serves as a cofactor for the in vitro response of T lymphocytes to antigen and plays an important role in regulating the growth and/or differentiation of these cells (1, 2). The self-interaction of native TDP-43 C terminus inhibits its degradation and contributes to early proteinopathies. Thus we were able to demonstrate that the global repressor Tup1p can modulate transcription by interacting with an activator. The spectral dependent photocurrent and photopotential behaviors of ZnO nanorods and CdS sensitized ZnO nanorods have been investigated using monochromatic light of wavelength 300-700 nm.

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The yeast regulatory protein kinase, general control non-derepressible-2 (GCN2) plays a key role in general amino acid control. Trials were presented either in a blocked design (so that the subjects knew a priori the contextual information in the display) or in a mixed design. Camptothecin schedule and timing of administration with irradiation. As hospital marketing programs continue to develop both in number and sophistication, the role and importance of consumer image and preference is increasingly recognized. It explains what physical conditions, mainly contributed to the scanning stylus, are thought to play a part in the limitations in imaging these cells. By single-cycle replication and immunoprecipitation/immunoblotting analyses, mutants designated W21A, S32A, W38A, Y40A, and H43A were demonstrated to hardly or poorly bind to and neutralize A3G. Large-scale two-hybrid screens have generated a wealth of information describing potential protein--protein interactions. The proposed mechanisms of initiation are haemorrhage, impaired drainage and obstruction of ventilation. This article also reviews data on toxicity, specifically focusing on differences between various formulations of growth factors.

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Two patients who had had idiopathic steatorrhoea for several years developed typical eruptions of dermatitis herpetiformis. Reactions of (1R,5S)-3-benzyl-7-(2-methylprop-1-enyl)-2-oxa-4,7-diazabicyclo(3.2.0)hept-3-3n-6-one with alcohols and with acids. High-dose influenza vaccine favors acute plasmablast responses rather than long-term cellular responses. The extracellular melanoid pigment of Actinomyces brunneorectus actinomycetes. Apropos of a transverse epidemiological study in a long-term stay facility. To prevent outbreaks, in addition to infection control measures, the implementation of HCW vaccination is very important. The total cholesterol content of the blood and tissues sumycin drugs of rodents developing under different motor activity conditions. Functional classification of swine manure management systems based on effluent and gas emission characteristics. Kinetic analysis of the effects of plasmid multimerization on segregational instability of CoIE1 type plasmids in Escherichia coli B/r. Interligand Overhauser effects in type II dihydrofolate reductase.

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