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Nolvadex (Tamoxifen)
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Nolvadex

Nolvadex is used to treat breast cancer that has spread to other parts of the body in men and women. It is used to treat early breast cancer in women who have already been treated with surgery, radiation, and/or chemotherapy.

Other names for this medication:
Caditam, Mamofen, Oncomox, Oncotam, Tamodex, Tamoxifen, Tamtero, Tevafen, Tomifen, Valodex, Xifen

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Also known as: Tamoxifen

Description

Nolvadex target is the treatment of breast cancer. Nolvadex is also taken to decrease the risk of breast cancer development, especially in women after surgery and radiation due to DCIS (ductal carcinoma in situ). Sometimes Nolvadex is taken to produce female ovulation and to treat McCune-Albright syndrome. Nolvadex is acting by blocking effect of female hormone called estrogen. It is antiestrogen. Nolvadex is also known as Tamoxifen, Blastofen, Istubal, Valodex, Soltamox, Genox, Tamofen.

Dosage

This section provides information on the proper use of a number of products that contain tamoxifen. It may not be specific to Nolvadex. Please read with care.

Use this medicine only as directed by your doctor. Do not use more of it, do not use it more often, and do not take it for a longer time than your doctor ordered.

Medicines used to treat cancer are very strong and can have many side effects. Before using this medicine, make sure you understand all the risks and benefits. It is important for you to work closely with your doctor during your treatment.

This medicine comes with a Medication Guide. Read and follow these instructions carefully. Ask your doctor if you have any questions.

Shake the oral liquid well before each use. Measure the medicine with a marked medicine cup. The average household teaspoon may not hold the right amount of liquid.

Swallow the tablets whole with a glass of water. Do not break, divide, crush, or chew it. You can take the tablets with or without food.

Tamoxifen sometimes causes mild nausea and vomiting. However, it may have to be taken for several weeks or months to be effective. Even if you begin to feel ill, do not stop using this medicine without first checking with your doctor. Ask your health care professional for ways to lessen these effects.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For oral dosage form (solution, tablets): For breast cancer: Adults—20 to 40 milligrams (mg) per day. Doses greater than 20 mg are given as 2 divided doses per day (morning and evening). Children—Use and dose must be determined by your doctor. For breast cancer as additional treatment: Adults—20 milligrams (mg) per day for 5 to 10 years. Children—Use and dose must be determined by your doctor. For reducing the risk of developing breast cancer in high-risk women: Adults—20 milligrams (mg) per day for 5 years. Children—Use and dose must be determined by your doctor. For reducing the risk of developing invasive breast cancer in women with ductal carcinoma in situ: Adults—20 milligrams (mg) per day for 5 years. Children—Use and dose must be determined by your doctor.

Overdose

If you overdose Nolvadex and you don't feel good you should visit your doctor or health care provider immediately. Symptoms of Nolvadex overdosage: uncontrolled body shaking, unsteadiness, problems with walking, convulsions, lightheadedness, exaggerated reflexes, problems with breathing, tremor.

Storage

Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F) away from moisture, light and heat. Keep container tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Nolvadex are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Appropriate studies have not been performed on the relationship of age to the effects of tamoxifen in the pediatric population. Safety and efficacy have not been established.

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Impact of overlapping recruitment on psychiatric genetic studies. The experience provides trainees with basic surgical skills well before they begin their third-year clerkships. Evolution of Porosity and Channelization of an Erosive Medium Driven by Fluid Flow. We examined the rotational vestibular responses of carefully screened dyslexic and control populations (34 dyslexics and 33 controls). The BMD was measured in the lumbar spine (L1-L4), the femoral neck, and total femur region. Acetylcholinesterase (AChE) activity examined histochemically in spinal neurons and AChE and choline acetyltransferase (ChAT) activities were measured biochemically in axons of developing hindlimb motoneurons. This study aimed to compare urinary and bowel symptoms and quality of life (QoL) among women treated with a Wertheim-Meigs (WM, type III) or Wertheim-Okabayashi (WO, type IV) radical hysterectomy with pelvic lymphadenectomy for early-stage cervical cancer. With the recent simplification of intravenous (IV) iron administration (ferric carboxymaltose) and its approval in many countries for iron deficiency, physicians may be inclined to overutilize it as a first-line substitution. Acquired pendular nystagmus with oscillopsia in multiple sclerosis: a sign of cerebellar nuclei disease. This procedure, based on the model proposed by Imanaka and Aiba, provides quantitative information on the rate of plasmid loss and the difference in the specific growth rate between the plasmid-carrying and plasmid-free cells.

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This contrasts with the reports of GR mutations preferentially suppressing GR-mediated induction. Though it is well described histopathologically, publications regarding its cytologic findings are limited. In brief Pregnant women undergo anatomic and physiologic changes that make certain problems, such as low-back pain and fluid retention, almost inevitable. The starting material showed statistical N-acetyl (N-Ac) distribution along the polymer chain according to the rules of Bernoulli, with highest abundance of the GlcNAc-GlcNAc diad along with a lower abundance of triads, tetrads, and pentads. Design and operating improvements that can be achieved by studying the performance of the model are also discussed. The authors recommend that non symptomatic or slightly exposed patients do not need any specific treatment or symptomatic treatment is sufficient. Using a cytotoxic assay with a monoclonal antiplacental ferritin antibody which was developed by C. We suggest that the threshold theolair medication for contrast studies and operative intervention should be low in neurologically impaired patients to avoid the delay in treatment of tube-related complications. Achieving these goals involves challenges in rethinking many paradigms for the conduct of basic and clinical cancer research and for the organization of interdisciplinary collaboration.

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