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Nexovas

Nexovas is a beta-blocker used to treat chest pain (angina), heart failure, and high blood pressure. Lowering high blood pressure helps prevent strokes, heart attacks, and kidney problems. This drug works by blocking the action of certain natural chemicals in your body (such as epinephrine) that affect the heart and blood vessels. This lowers heart rate, blood pressure, and strain on the heart.

Other names for this medication:
Actiblok, Actocard, Asoprol, Betaloc, Betaone, Blumeta, Cadmet, Dutoprol, Intramet, Macsart, Mepol, Metapro, Metin, Metocare, Metofin, Metolar, Metolex, Metomac, Metoprolol, Metozest, Metpure, Metscore, Metzok, Nexovas, Powermet, Sitelol, Supermet, Telidin, Teliprolol, Toprol, Translol, Vasomet, Vinicor, Vivalol

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Also known as: Metoprolol

Description

Metoprolol is used alone or together with other medicines to treat high blood pressure (hypertension). High blood pressure adds to the workload of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. A lower blood pressure can reduce the risk of strokes and heart attacks.

Metoprolol is also used to treat severe chest pain (angina) and lowers the risk of repeated heart attacks. It is given to people who have already had a heart attack. In addition, metoprolol is used to treat patients with heart failure.

This medicine is a beta-blocker. It works by affecting the response to nerve impulses in certain parts of the body, like the heart. As a result, the heart beats slower and decreases the blood pressure. When the blood pressure is lowered, the amount of blood and oxygen is increased to the heart.

This medicine is available only with your doctor's prescription.

Dosage

This section provides information on the proper use of a number of products that contain metoprolol. It may not be specific to Nexovas. Please read with care.

Take this medicine only as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. Your dose may need to be changed several times in order to find out what works best for you.

In addition to the use of this medicine, treatment for your high blood pressure may include weight control and changes in the types of food you eat, especially foods high in sodium (salt). Your doctor will tell you which of these are most important for you. You should first check with your doctor before changing your diet.

Many patients who have high blood pressure will not notice any signs of the problem. In fact, many patients feel normal. It is very important that you take your medicine exactly as directed and that you keep your appointments with your doctor even if you feel well.

Remember that this medicine will not cure your high blood pressure, but it does help control it. You must continue to take it as directed if you expect to lower your blood pressure and keep it down. You may have to take high blood pressure medicine for the rest of your life. If high blood pressure is not treated, it can cause serious problems such as heart failure, blood vessel disease, strokes, or kidney disease.

Swallow the extended-release capsule and tablet whole. Do not crush, break, or chew them.

If you cannot swallow the extended-release capsule:

You may open it and sprinkle the contents over a small amount (teaspoonful) of soft food (including applesauce, pudding, or yogurt). Swallow the mixture within 60 minutes. Do not store for later use. You may also use a nasogastric tube to give the medicine. Mix the contents of the opened capsule with water into a syringe. Gently shake the mixture for about 10 seconds, then flush it through the tube. Rinse the tube with water until all of the medicine is washed out.

Take the tablet or extended-release tablet with a meal or just after you eat. You may break the extended-release tablet into two pieces, but swallow the two pieces whole and do not crush or chew them.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For acute heart attack or heart failure: For oral dosage form (extended-release capsules): Adults—At first, 25 milligrams (mg) once a day for 2 weeks. Your doctor may adjust your dose as needed. However, the dose is usually not more than 200 mg per day. Children—Use and dose must be determined by your doctor. For oral dosage form (extended-release tablets): Adults—At first, 25 milligrams (mg) once a day for 2 weeks. In patients with severe heart failure, the starting dose is 12.5 mg once a day. Your doctor may adjust your dose as needed. Children—Use and dose must be determined by your doctor. For oral dosage form (tablets): Adults—At first, 50 milligrams (mg) every 6 hours for 2 days. Then, 100 mg 2 times a day. The medicine will be started in the hospital. Children—Use and dose must be determined by your doctor. For chest pain: For oral dosage form (extended-release capsules): Adults—At first, 100 milligrams (mg) once a day. Your doctor may adjust your dose as needed. However, the dose is usually not more than 400 mg per day. Children—Use and dose must be determined by your doctor. For oral dosage form (extended-release tablets): Adults—At first, 100 milligrams (mg) once a day. Your doctor may adjust your dose as needed. However, the dose is usually not more than 400 mg per day. Children—Use and dose must be determined by your doctor. For oral dosage form (tablets): Adults—At first, 100 milligrams (mg) per day, given in two divided doses. Your doctor may adjust your dose as needed. However, the dose is usually not more than 400 mg per day. Children—Use and dose must be determined by your doctor. For high blood pressure: For oral dosage form (extended-release capsules): Adults—At first, 25 to 100 milligrams (mg) once a day. Your doctor may adjust your dose as needed. However, the dose is usually not more than 400 mg per day. Children 6 years of age and older—Dose is based on body weight and must be determined by your doctor. The dose is usually 1 milligram (mg) per kilogram (kg) of body weight once a day. The first dose should not be more than 50 mg once a day. Your doctor may adjust your dose as needed. Children younger than 6 years of age—Use and dose must be determined by your doctor. For oral dosage form (extended-release tablets): Adults—At first, 25 to 100 milligrams (mg) once a day. Your doctor may adjust your dose as needed. However, the dose is usually not more than 400 mg per day. Children 6 years of age and older—Dose is based on body weight and must be determined by your doctor. The dose is usually 1 milligram (mg) per kilogram (kg) of body weight per day, given as a single dose. The first dose should not be more than 50 mg per day. Children younger than 6 years of age—Use and dose must be determined by your doctor. For oral dosage form (tablets): Adults—At first, 100 milligrams (mg) per day, given as a single dose or in divided doses. Your doctor may adjust your dose as needed. However, the dose is usually not more than 450 mg per day. Children—Use and dose must be determined by your doctor. .

Overdose

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include fast or slow heart rate, trouble breathing, or fainting.

Storage

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Nexovas are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

You should not use this medicine if you are allergic to hydrochlorothiazide or metoprolol, or if you have:

a serious heart condition such as "sick sinus syndrome" or "AV block" (unless you have a pacemaker), or if your heart cannot pump blood properly; slow heartbeats that have caused you to faint; severe or uncontrolled heart failure; an allergy to sulfa drugs; or if you are unable to urinate.

Tell your doctor if you have ever had:

congestive heart failure; slow heartbeats; blood circulation problems; asthma or other breathing disorder; peripheral vascular disease such as Raynaud's syndrome; diabetes; a thyroid disorder; kidney disease (or if you are on dialysis); pheochromocytoma (tumor of the adrenal gland); glaucoma; lupus; gout; or high cholesterol or triglycerides.

Tell your doctor if you are pregnant or breastfeeding.

Nexovas HCT is not approved for use by anyone younger than 18 years old.

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Comparative evaluation of bonding strength of computer aided machined ceramic, pressable ceramic, and milled metal implant abutment copings and effect of surface conditioning on bonding strength: An in vitro study. Nevertheless, hydrophobic interactions increased the larvicidal activity. Phyllodes tumours are uncommon fibroepithelial lesions that typically grow up to 4cm in size but 10cm tumours known as giant phyllodes tumours have been described. Qualitative and quantitative data were analyzed to evaluate the perception of the course. Mutations in the Autographa californica multinucleocapsid nuclear polyhedrosis virus 25 kDa protein gene result in reduced virion occlusion, altered intranuclear envelopment and enhanced virus production. A seven-year-old boy with a retrovesical diverticulum and ipsilateral renal dysplasia is reported. These same factors as well as mechanical complications in which a coronary artery is briefly occluded or stenosed prior to a subsequent coronary occlusion may lead to inadvertent preconditioning and confound the results of experimental cardiology studies. Scientific studies in drug development and toxicology rely heavily on animal models, which often inaccurately predict the true response for human exposure.

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A higher IL-10 secretion and a lower IFN-gamma secretion were detected in Adv-IKK2dn-DC-stimulated allogenic T cells. These findings are particularly interesting for risk assessment since all available data on occupational exposure to BPA through thermal paper were obtained from models or from simulated experiments. The utility of a conjugate of ?-bungarotoxin and horse-radish peroxidase for the histochemical visualization of binding sites of intact axons or axonal vesicles is discussed. Genetic demographic networks: Mathematical model and applications. Genetic mosaic analysis of the equatorial-less mutation in Drosophila melanogaster. More long-term population-based studies are needed to precisely determine the development of HRQoL among PwMS. In the diet-induced model of NIDDM, Gs alpha expression in the liver was twofold greater in obese/diabetic mice as compared with lean controls. nidulans mutants it is probable that this subfamily is involved in complex regulatory pathways. Nevertheless, a high local and systemic level of TNFalpha prior to TNFalpha blocker therapy seems to be associated with a good clinical response.

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Estimating oil pollution risk in environmentally sensitive areas of petrochemical terminals based on a stochastic numerical simulation. A 56-years-old woman, who had undergone a complete resection for atypical meningioma (grade 2 of World Health Organization classification)8 years before was admitted to our hospital to treat a mass on the right middle lobe detected by chest X-ray. Several types of asymmetries are described, along with the biomechanics needed for correction. A literature search was performed on medical database MEDLINE, engineering database IEEE-Xplore and wide-raging scientific databases Scopus and Web of Science. Furthermore, the pro-apoptotic protein, Bad was upregulated and antiapoptotic protein, Bcl-xl was downregulated during nitroalkene-induced apoptosis. Comparative evaluation of various methods of application of proserine in week labor contraction activity. LMB efficiently inhibited vRNP export, while it did not affect the subcellular localization and export of matrix protein (M) 1 and nonstructural protein (NS) 2. Furthermore, the application of systems-biology approaches to organize and analyze data regarding the lung proteome, interactome, genome, transcriptome, metabolome, glycome and small RNAome (regulatory RNAs), should facilitate future conceptual advances regarding lung cell biology, disease pathogenesis, biomarker discovery and drug development. This genotype was found to have reproductive abnormalities associated with its complex subspecies origin that are best described as hybrid breakdown.

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Implications of these findings for the development of programs and services for families on welfare are discussed. We present the correlation between excised specimen size in laparoscopic sleeve gastrectomy and patient demographics, comorbidities, and postoperative weight loss. Rhodamine-labeled liposomes were used to quantify cell association via fluorometry, live/dead dual stain was used to measure cytotoxicity, and gene silencing was measured by quantitative polymerase chain reaction. Cyclosporine in common clinical practice: an estimation of the benefit/risk ratio in patients with rheumatoid arthritis. We model the education-workforce pipeline and offer an endogenous theory of professionalization and ever-higher degree attainment. Systematic database searches in PubMed and EMBASE with the following search components: QST, association, and postoperative pain, for studies that assessed the association between QST and pain after surgery were performed. 2D X-ray diffraction analysis of unidirectionally oriented nanotube samples, prepared by using the capillary technique, revealed that although FcL1 as reported previously stacks helically in the resulting nanotube FcNT1 FcL2 prefers to stack with no discernible helical twist in FcNT2. Synthetic biology principles may bring some new possible methods for curing cancer. In normal thyroid follicular cells, stimulation of the thyroid-stimulating hormone (TSH) receptor activates the cyclic adenosine monophosphate (cAMP) pathway and promotes cell growth as well as hormonal secretion.

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Population dynamics provides a numerical tool allowing their study, by means of simulating a large number of copies of the system, which are subjected to selection rules that favor the rare trajectories of interest. To examine and compare patient and oncologist preferences for advanced melanoma treatment attributes and to document their trade-offs for benefits with risks. The histology of the reproductive organs, seminiferous tubules and epididymis of the transgenic mice was observed with HE staining. This observation has spawned a lively debate as to whether the temporal structure of the initial adaptive response is, in fact, stereotyped and non-specific. Although rare, STA represents a complication of low energy trauma that requires elective surgical management. The groups treated with topical retinoids showed an additional significant increase in ceramide subfractions, most probably reflecting their influence on epidermal keratinization. pararoseus represents an alternative gene source for the reconstruction of carotenogenic pathways vital for the production of engineered carotenoids. Magnetic behavior of metallic kagome lattices, Tb3Ru4Al12 and Er3Ru4Al12.

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We report a one-step polymer-free approach to patterning graphene using a stencil mask and oxygen plasma reactive-ion etching, with a subsequent polymer-free direct transfer for flexible graphene devices. Extraction of a bean sized ureteral calculus by Zeiss catheter in a 2 1/2 year old child - remaining right kidney - reflex anuria. Participants were assessed for adverse events and progression of disease, as measured by the ALS Functional Rating Scale-Revised, forced vital capacity, and quantitative measures of strength. Complication rates were comparable to rates reported in the literature for attending-performed LPIs. As discussed in the article, fine and almost always organic sediments prevail, which is a considerable obstacle to the end disposal and possibility of reuse. The glycan component of gp41 is, therefore, important for the efficient intracellular transport and processing of gp160.

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Past users and users of systemic HRT were at higher risk of TKR compared to never users. Multidisciplinary approach to manage antenatally suspected placenta percreta: updated algorithm and patient outcomes. The results show that cultured Schwann cells continue to exhibit immunogenicity and are a critical factor in allograft survival. The actin cytoskeleton has major roles in the morphological development of neurons. To determine the comprehension of an elevated amyloid positron emission tomographic (PET) biomarker result by cognitively unimpaired adults. Sporotrichosis in a protonix liquid form dosage liver transplant patient: A case report and literature review.

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Diagnostic errors in surgical pathology uncovered by a review of malpractice claims. Duration of arrhythmia, left atrial (LA) size, ejection fraction (EF), time to conversion, QTc interval, and adverse drug events were determined. To evaluate the role of NG-methyl-L-arginine as a modulator of the hyperdynamic shock induced by the administration of interleukin-2 (IL-2). A series of functional pan-genomic analyses provide conserved and unique types of genomic evidence for strong epistatic and pleiotropic impacts on desyrel generic name evolutionary trajectories of the PAH-degrading phenotype. The implementation of mental health awareness programmes, interventions aimed at high risk groups and addressing trauma-related symptoms from all causes are needed in the Kashmir Valley. In this small number of patients, no significant differences in exposure were seen after ingestion of either a normal or high-fat breakfast. Several models have been used for the parametrization of the interaction between the adsorbed atoms.

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Genetic interaction of DISC1 and Neurexin in the development of fruit fly glutamatergic synapses. Among 50,805 persons who participated in the third survey of the HUNT Study (HUNT3), 16,247 participants from three municipalities were included. Multidetector computed tomographic features of oncocytic papillary renal cell carcinoma, a new subtype. Previous experimental studies carried out on model plant organisms such as A. Early food supplemented nests therefore seemed to include at least some nestlings that faced increased stressors during development, possibly due to harsher environmental (e.g., related to food and temperature) conditions early in the breeding season that would increase sibling competition, especially in larger broods. The discrepancy in the effects of semantic context and F0 contours on L2 speech recognition in the interfering background might be related to differences in processing capacities required by the two types of information in adverse listening conditions. We introduce a corresponding system of coupled non-linear equations for both continuum electrostatics with a uniform dielectric constant, and a structured solvent-a dipolar Coulomb fluid-including non-local effects.

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It is often easier to give an alternative agent rather than to determine if the person does indeed have a hypersensitivity reaction to a particular drug. Implications for routine assessment and screening to identify families at risk and recommendations for future research are highlighted. Although endocrine stress responses of coronary artery bypass patients have been reported, similar studies have not been conducted in patients undergoing implantation of an automatic cardioverter/defibrillator device. Over the past years, the multidisciplinary character of the international Computer-Aided Surgery around the Head (CAS-H) symposium has advanced many medical technologies, which were often adopted by industry. We selected newly diagnosed ischemic stroke patients from 2002 to 2013 using stratified representative sampling data of 1,025,340 subjects. Correction: trans-kingdom horizontal DNA transfer from bacteria to yeast is highly plastic due to natural polymorphisms in auxiliary nonessential recipient genes. Screening, prevalence and ethnic variation of diabetes mellitus in people with acute stroke and transient ischaemic attack: a cross-sectional study in Northland, New Zealand. This propensity of levaquin tablets 500 mg AAT to form stable beta-structures in a hydrophobic surrounding may contribute to improved characterization of various amyloid deposits occurring in vivo and be a guide for understanding details of structure-function relationships in the intact AAT-molecule. Silver-containing dressings for the prevention of surgical site infections (SSIs) remained controversial, and accumulating evidence was lacking, so a meta-analysis was conducted to systematically assess the effectiveness and safety of silver-containing dressings for clean and clean-contaminated surgical incisions. To investigate the protective effects against ischemia reperfusion injury of dipyridamole in a model of induced priapism in rats.

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Costs were determined adapting World Health Organization vaccination costing guidelines. Initiation of inadequate empiric antibiotic therapy is associated with a worse outcome. Integrated imaging approach to tumor model mice using bioluminescence imaging and magnetic resonance imaging. The magnitude of social inequalities in self rated health was similar in Sweden and in Britain. And inhibition of Sirt1 expression increased the expressions of Glut1 and Glut4. Mesenchymal stromal cells (MSCs) have been reported to provide paracrine signals that promote wound healing, but (i) how they exert their effects on target cells is unclear and (ii) a suitable delivery system to supply these MSC-derived secreted factors in a controlled and safe way is unavailable. Cigarette smoking is the leading cause of lung cancer worldwide. In this work, a Q-spoiling technique using a depletion-mode Gallium Nitride HEMT device was developed for coil detuning at both 1.5 T and 3 T MRI. The release rate data were investigated by using zero-order, first-order, Hixson-Crowel and Higuchi kinetics. Impact of infection control measures on psychosocial health: a study on the post-stroke elders.

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Switching of the rotational direction of rhizoidal colonies in a newly isolated Bacillus mycoides strain Ko01. Compelling evidence supports the idea that the different impact of cardiovascular disease and the differences in vascular biology in men and women may be, at least in part, related to the cardiovascular and metabolic effects of sex steroid hormones. Parasite-mediated sexual selection is proposed to affect parasite biology by increasing (1) the variance-to-mean ratio in parasite abundance, (2) variance in the intensity of natural selection affecting hosts, and (3) speciation rates among parasites exploiting hosts subject to intense sexual selection as compared to those subject to less intense selection. Percutaneous coronary intervention for patients with left main coronary artery disease was found to be a safe and effective strategy in our hospital without on-site cardiac surgery. However, in rats there was almost no corneal damage after ERG recordings with the CLE. Therefore, we aimed to determine factors that are associated with both NASH and advanced fibrosis in patients with diabetes and NAFLD in order to identify who should be prioritized for referral to a hepatologist for further diagnostic evaluation and treatment. Families of children who survive out-of-hospital cardiac arrest and have high risk for neurologic disability often experience substantial burden during the first year post arrest. Hyperalgesic effect of intrathecally administered interleukin-1 in rats.

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