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Losazide (Losartan)
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Losazide

Losazide belongs to a group of drugs called angiotensin II receptor antagonists (sometimes called ARB blockers). It keeps blood vessels from narrowing, which lowers blood pressure and improves blood flow. Losazide is used to treat high blood pressure (hypertension) in adults and children who are at least 6 years old. It is also used to lower the risk of stroke in certain people with heart disease.

Other names for this medication:
Cardoplus, Cormac, Enromic, Forzaar, Insaar, Lacine, Lepitrin, Lohyp, Loortan, Lopress, Losacor, Losadrac, Losamet, Losartanum, Losartic, Lozar, Lozatan, Mozartan, Osartan, Ranlozar, Rosatan, Tacardia, Temisartan, Tozaar, Zaart

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Also known as: Losartan

Description

Losazide (losartan potassium) is an angiotensin II receptor blocker acting on the AT1 receptor subtype. Losartan potassium, a non-peptide molecule, is chemically described as 2-butyl-4-chloro-1-[p-(o-1Htetrazol- 5-ylphenyl)benzyl]imidazole-5-methanol monopotassium salt.

Losazide is a white to off-white free-flowing crystalline powder with a molecular weight of 461.01. It is freely soluble in water, soluble in alcohols, and slightly soluble in common organic solvents, such as acetonitrile and methyl ethyl ketone. Oxidation of the 5-hydroxymethyl group on the imidazole ring results in the active metabolite of losartan.

Losazide is available as tablets for oral administration containing either 25 mg, 50 mg or 100 mg of losartan potassium and the following inactive ingredients: microcrystalline cellulose, lactose hydrous, pregelatinized starch, magnesium stearate, hydroxypropyl cellulose, hypromellose, and titanium dioxide.

Losazide 25 mg, 50 mg and 100 mg tablets contain potassium in the following amounts: 2.12 mg (0.054 mEq), 4.24 mg (0.108 mEq) and 8.48 mg (0.216 mEq), respectively. Losazide 25 mg, Losazide 50 mg, and Losazide 100 mg may also contain carnauba wax.

Dosage

Take Losazide tablets orally with or without food. Do not crush or chew it. Take Losazide once or twice a day at the same time. If you want to achieve most effective results do not stop taking Losazide suddenly.

Overdose

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Storage

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture, light and heat. Keep container tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children in a container that small children cannot open.

Side effects

The most common side effects associated with Losazide are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Do not take Losazide if you are allergic to Losazide components. Do not take Losazide if you're pregnant or you plan to have a baby, or you are a nursing mother. Losazide can harm your baby. Do not use Losazide if you are taking salt substitutes or potassium supplements, other blood pressure medicine, diuretic (water pill). It can be dangerous to use Losazide if you suffer from or have a history of liver disease, kidney disease, heart failure. If you want to achieve most effective results without any side effects it is better to avoid alcohol. Avoid machine driving. Do not stop taking Losazide suddenly.

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Chemical and toxicological evaluations of isolated and synthetic chloro derivatives of dibenzo-p-dioxin. The aim of this study was to analyze the prognostic factors related to the recurrence rate and overall survival of vulval melanoma patients by means of a subgroup analysis of the VULvar CANcer study. We report the case of a 40-year-old woman who presented with symptomatic gallbladder stones. To review society, ethical and anaesthesiological issues related to circumcision in children. In order to observe process parameters, the motion usually has to be disrupted. Low heritabilities for pathogen specific-mastitis resistance may be considered when including bacteriological status as a measure of mastitis presence to implement breeding strategies for improving udder health in dairy ewes.

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