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Lipitor

Lipitor helps improve your cholesterol levels and is a common first-choice medication for people with high cholesterol or heart disease. It is also used for people who are at higher risk of heart disease, such as those with diabetes, even though they may have normal cholesterol levels.

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Also known as: Atorvastatin

Description

Lipitor (atorvastatin) belongs to a group of drugs called HMG CoA reductase inhibitors, or "statins."

Lipitor is used together with diet to lower blood levels of "bad" cholesterol (low-density lipoprotein, or LDL), to increase levels of "good" cholesterol (high-density lipoprotein, or HDL), and to lower triglycerides (a type of fat in the blood).

Lipitor is used to treat high cholesterol, and to lower the risk of stroke, heart attack, or other heart complications in people with type 2 diabetes, coronary heart disease, or other risk factors such as genetically high cholesterol.

Lipitor is for use in adults and children who are at least 10 years old.

Dosage

Take Lipitor exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose to make sure you get the best results. Do not use this medicine in larger or smaller amounts or for longer than recommended.

Lipitor is usually taken once a day, with or without food. Take the medicine at the same time each day.

Do not break an Lipitor tablet before taking it, unless your doctor has told you to.

You may need to stop using this medicine for a short time if you have:

uncontrolled seizures; an electrolyte imbalance (such as high or low potassium levels in your blood); severely low blood pressure; a severe infection or illness; or surgery or a medical emergency.

It may take up to 2 weeks before your cholesterol levels improve, and you may need frequent blood test. Even if you have no symptoms, tests can help your doctor determine if Lipitor is effective.

Lipitor is only part of a complete treatment program that may also include diet, exercise, and weight control. Follow your doctor's instructions very closely.

Store at room temperature away from moisture, heat, and light.

Detailed Lipitor dosage information

Overdose

If you overdose Generic Lipitor and you don't feel good you should visit your doctor or health care provider immediately.

Storage

Store at room temperature between 20 to 25 degrees C (68 to 77 degrees F) away from moisture and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Lipitor are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

You should not use Lipitor if you are allergic to atorvastatin, or if you have:

liver disease; or if you are pregnant or breastfeeding.

Atorvastatin can harm an unborn baby or cause birth defects. Do not use if you are pregnant. Stop taking Lipitor and tell your doctor right away if you become pregnant. Use effective birth control to prevent pregnancy while you are taking this medicine.

Atorvastatin may pass into breast milk and could harm a nursing baby. Do not breastfeed while you are taking Lipitor.

To make sure this medicine is safe for you, tell your doctor if you have ever had:

liver problems; muscle pain or weakness; kidney disease; diabetes; a thyroid disorder; or if you drink more than 2 alcoholic beverages daily.

Lipitor can cause the breakdown of muscle tissue, which can lead to kidney failure. This happens more often in women, in older adults, or people who have kidney disease or poorly controlled hypothyroidism (underactive thyroid).

Atorvastatin is not approved for use by anyone younger than 10 years old.

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Most identified mutations either led to a predictable premature stop codon or resulted in splicing defects, which caused defective function of dystrophin. To study the accuracy and precision of the pressure measurements obtained with a new rectal balloon catheter (ref. As a result of deinstitutionalization, families are frequently the primary caretakers of chronically mentally ill relatives. It therefore appears that presynaptic noradrenergic alpha2 and postsynaptic alpha1 adrenoceptor stimulation exert opposing effects on the behavioural expression of MK-801 in mice. This is the pathway of the transfer of information from the mitochondria to the nucleus. Physicochemical methods for diagnosing hyperlipoproteinemias, by determining the concentrations of apolipoproteins and protein vectors (lecture 3). Oncogenic Ras triggers hyperproliferation and impairs polarized colonic morphogenesis by autocrine ErbB3 signaling. Significantly, transplantation of OECs constitutes a promising novel therapy for nerve injuries, but results are highly variable and the method needs improvement. CLINICAL AND OPERATIVE IDENTIFICATION OF INCOMPETENT COMMUNICATING VEINS AND ATTEMPTED DETERMINATION OF THEIR SIZE.

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Automated analysis of viral integration sites in gene therapy research using the SeqMap web resource. Established therapeutic concepts for heart failure in elderly patients aim at long-term medical and/or surgical palliation. Our objective was to evaluate the effect of blocking the renin-angiotensin system (RAS) on the expression of transforming growth factor-beta 1 (TGF-beta1), platelet derived growth factor-B (PDGF-B), tumour necrosis factor-alpha (TNF-alpha) and vascular endothelial growth factor (VEGF) in diabetic kidney glomeruli. Validation of the (31)P NMR methodology for quantitative analysis of phospholipids in olive oil was performed. Diastolic blood pressure drop after standing as a clinical sign for increased mortality in older falls clinic patients. ON THE PHYSIOLOGY OF METABOLISM OF CONTRAST MEDIA WITH RENAL EXCRETION. Thermal decomposition of the sodium salts of tosylhydrazone derivatives of 1-trimethylsilylcyclopropyl alkyl ketones also gave methylenecyclopropane products derived from trimethylsilyl migration. Its expression is regulated, in part, by messenger RNA (mRNA)-binding proteins that control the stability of Ptgs2 mRNA.

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FALSE ANEURYSM OF THE EXTERNAL MAXILLARY ARTERY: REPORT OF CASE. Method of graphic registration of the motor function of the gallbladder in dog. The initial phase (10 min) of the excitotoxic responses were very similar, however the final outcome was different: usually, irreversible damage was restricted to patches of tissue following N-methyl-D-aspartic acid pulses. Thirty-one newly diagnosed allergic rhinitis patients and 29 healthy controls were included in the study. IL-27: a potential biomarker for responders to glatiramer acetate therapy. With the exception of week 5 and 14, 25-h Holter monitorings were done weekly. We previously reported the phosphorylation on tyrosine of phospholipid scramblase 1 (PLSCR1) after FcepsilonRI aggregation. Vascular density was determined by counting the blood vessels in 6 fields with 100 (HPF) on hematoxylin-eosin stained slides. EXOPHTHALMUS-PRODUCING FACTOR AND THYROID IODINE CONTENT IN ENDOCRINE OPHTHALMOPATHY. We conducted a morphometric study of the proximal radius at the level of the safe zone to identify different morphologic types of this anatomical region.

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There were 1.5-2-fold excesses in the MAC of benzpyrene in the places where apartment houses were contiguous with industrial enterprises and highways and 2.5-3-fold excesses in the ambient air of an industrial zone. Lack of attention to umbilical hygiene usually plays a role in their formation. In this study, a random peptide library in which peptide sequences are displayed on the E. Skin tests for chlorhexidine were undertaken 5 weeks later, showing positive prick and intradermal skin tests. The confounding effects of the traditions of psychology are discussed. Measurement of regional cerebral blood flow with 133xenon and a multiple-crystal scintillation camera. dehydrative condensation) such as steric hindrance and electronic properties of the reactants become practically negligible.

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This article reviews the current literature on the viral agents that cause reproductive failures in domestic carnivores (dogs and cats). A 32-yr-old man developed progressive exertional dyspnea 4 yr after blunt chest trauma due to an automobile accident. Effects of age on muscarinic cholinergic receptors in rat myocardium. Tumor-induced angiogenesis resulted in growth stimulation of tumor spheroids, disappearance of central necrosis and a reduction of the pericellular oxygen pressure. The study of castrated males and females and of androgen-treated females suggests that androgens exert an inhibitory effect on these SLE symptoms. This review highlights recent work that uses protein-DNA crosslinking, immunoprecipitation and DNA microarrays to determine the binding sites for specific transcription factors throughout the yeast genome. Molecular epidemiological approaches have provided new insights into the natural history of TB with important implications for drug resistance. Current osteoarthritis treatment, prescribing influences and barriers to implementation in primary care. A fluorescein angiographic study of macular dysfunction secondary to retinal vascular disease. After 24 h storage at 4 degrees C, the filterability of red cells was significantly decreased (P less than 0.01) and this could be partially prevented by adding dipyridamole to the stored cells (P less than 0.05).

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revealed different degrees of intra-individual polymorphism of the internal transcribed spacer (ITS 1, 5.8S rDNA and ITS 2) region due to the existence of putative non-functional copies (pseudogenes), putative recombinants and non-concerted evolution among functional copies. Propofol (2,6-diisopropylphenol) is a widely used intravenous anaesthetic that is formulated as an emulsion since it lacks water solubility. Simultaneous inhibition of two regulatory T-cell subsets enhanced Interleukin-15 efficacy in a prostate tumor model. The strong positive predictive value of both symptoms with ISD should encourage physicians to include direct questioning about these symptoms during the history taking and treatment planning for women with urinary incontinence. On the distribution of p32 in muscle adenosinetriphosphoric acid of a rabbit injected with radioactive phosphate.

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Estimation of drift and diffusion functions from time series data: a maximum likelihood framework. Congenital abnormalities of the anus with special reference to a case of anus vaginalis cured by surgery. Test gas equilibrium and subsequent washout were performed with HFV, succeeding measurements being performed at different stroke volumes (1.5-2.5 ml/kg body wt), oscillation frequencies (10-30 Hz), and with different lung volumes (32-74 ml X kg-1). Unfortunately, one patient had recurrent grade II bilateral ischial pressure sores after 11 months of ulcer-free period. We argue that most studies exploring real-life incidental learning use tests that are not as sensitive to low-confidence information as those traditionally used in laboratory tasks. Subsequently, perfusion of the tissue must be maintained by sympathetic blockades, infusions of low-molecular-weight dextrans and improving the microcirculation. Low temperature is one of the most important environmental stimuli that control gene transcription programs and development in plants. Naturalistic inquiry was adopted to elicit and explore the narrative accounts of participants about working together in general practice. The separation may be performed under denaturing or nondenaturing conditions and detergents may be added to promote protein solubilization. While innervation of bone was long appreciated, the discovery of central relays from the hypothalamus to the cells of bone has seen the identification of a number of efferent neural pathways to bone.

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The (18)F-FDG accumulation in reactive lymphadenopathy depended on secondary follicles. They comprise proteins of approximately 30 amino acids, containing a head-to-tail cyclized backbone, with three disulfide bonds configured in a cystine knot topology, therefore bearing greater peptide stability. A 14-fold increased sensitivity to a 1-h BBR 3464 exposure was found in OAW42MER cells compared with their parental cell line. It forms the basis for the design of a software sensor considering both a model of the biological system and on-line gaseous measurements. 1999: 131) for a distinctive fossil echinoid of the Thanetian (Palaeocene) age from Spain and considered to be the most ancient element of the echinoid family Aeropsidae Clark, 1917 (Spatangida, Echinoidea). Challenges to be overcome were cultural divides, language barriers and a need for skill development amongst consumers and others. The intact anti TNP response of NZB.xid mice may be an additional manifestation of immune abnormalities of the NZB strain and suggests that their B-cell populations differ from those of other mice in the conditions for activation.

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Effects of a 10-Week Nordic Hamstring Exercise and Russian Belt Training on Posterior Lower-Limb Muscle Strength in Elite Junior Soccer Players. However, this experience directed research to inflammatory mechanisms in MDD. This will also result in diverging preventive measures and decisions taken by the tissue facilities. moucheti populations sampled throughout its distribution range in Central Africa. Eighty-six Caucasian women who were identified to have PPTD at 6 months postpartum in a cross-sectional study of 748 women. Feedback based on kinematic measurements from a simple inertial sensor-based system can be used to modify key ACL injury risk metrics (knee flexion angle, trunk lean, knee abduction moment) during jump landing. All metal concentrations in surface soil of a polluted site (within Riyadh City) were higherthan those from a reference site (outside the city).Although Pb declined versus earlier reports on Riyadh soil, Cd (0.97 microg g(-1)) and Hg (0.28 microg g(-1)) were above some of the most stringent quality guidelines (0.07-0.62 microg g(-1) for Cd and 0.14-0.18 microg g(-1) for Hg). We identified incident upper and lower GI events and estimated their incidence rates using person-year methods in a population-based incident RA cohort of residents of Olmsted County, Minnesota, USA (1987 American College of Rheumatology criteria first fulfilled between January 1, 1980, and January 1, 2008) and non-RA subjects from the same population. Loss of alpha3beta1 integrin function results in an altered differentiation program in the mouse submandibular gland. Pharmacogenetic analyses have shed light on gene expression and polymorphisms as possible markers predictive of transporter activity.

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Control of cytokine production seems to be an effective management. The few pediatric case reports have described tendon entrapment associated with conservative fracture treatment, or have been recognized at subsequent revision surgery after failure to achieve closed fracture reduction. Surgical telementoring, consisting of an expert surgeon guiding a less experienced surgeon through advanced or novel cases from a remote location, is an evolving technology which has potential to become an integral part of surgical practice. A receiver-operating-characteristic (ROC) curve analysis showed that the Pe could reliably predict whether an error would be consciously perceived up to 400 ms before the average awareness response. Pathogenic function of IL-1 beta in psoriasiform skin lesions of flaky skin (fsn/fsn) mice. Furthermore, immunological reactions may play an important role in the pathogenesis since deposits of immunoglobulins, complement and fibrinogen can be demonstrated in the walls of capillaries and small vessels in the dermis of patients with acute meningococcaemia. The pathophysiological disturbances of this syndrome, which was defined by the American College of Rheumatology in 1990, are poorly understood. Bisphosphonates are a class of agents used to treat osteoporosis and malignant bone metastases. Aspergillus species are the cause of invasive mold infections in immunocompromised patients: Aspergillus fumigatus, A. The supraorbital foramen is a potential site of supraorbital nerve compression that can trigger frontal migraine headache.

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Electronic nicotine delivery systems (ENDS), or e-cigarettes, are heavily marketed online. A suboccipital craniectomy disclosed a subependymal hematoma bulging into the fourth ventricle. Other essential influencing factors include building capacity for coordination and facilitation of policy dialogues, provision of sustainable financing for execution of the dialogues, use of inclusive and bottom-up approaches, and timely provision of reliable evidence. The effect of Sandoglobulin(R) (SG) and albumin on the ROM release by PMNLs induced by a bioactive glass was studied by a chemiluminescence (CL) assay. Theoretical considerations on the subject of bone weakening due to metallic implants.

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Further studies are needed to verify our current findings using a larger sample size. Relapse rate in schizophrenia can be markedly reduced by effective maintenance neuroleptic treatments adhered to by the psychiatrist leaving more room for further reduction of relapse by implementing other measures such as lowering the expressed emotion, psychoeducation and rehabilitation. The aim was to assessing the safety of AFCo1 by single and repeated doses in Sprague Dawley rats. ST segment patterns during pacing in dogs with two lesions were consistent with the sum of the two individual lesions. During the fifth year of follow up, incident cardiovascular diseases, ABI, and mortality were documented, and related to ACE genotype adjusting for age, smoking, alcohol, dietary intake, physical activity, body mass index, and use of ACE inhibitors. Delayed identification and treatment of congenital loss of hearing. In contrast, growth on fibronectin and collagen type IV had no influence. Thus, with the discovery of new potential chemical entities, ERK inhibitors may emerge as a new therapeutic approach for the treatment of RA.

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Conditional rod photoreceptor ablation reveals Sall1 as a microglial marker and regulator of microglial morphology in the retina. We suggest that severe hyperbilirubinemia might affect the vestibular nuclei or the integrity of the inferior vestibular nerve and vestibulospinal tract. Human sepsis-based criteria were used to define SIRS in our rats to achieve an optimal analogy for the human system. Is the infiltration-centrifugation technique appropriate for the isolation of apoplastic fluid?. The CSTUER data fit the case of substrate inhibition kinetics with the apparent Michaelis constant approaching zero. Phosphorylation of neurofibromin by cAMP-dependent protein kinase is regulated via a cellular association of N(G),N(G)-dimethylarginine dimethylaminohydrolase. In six of the nine patients, one or more opportunistic infections were diagnosed from material obtained at bronchoscopy.

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The effect of exogenous T on parental behavior was examined by comparing duration of incubation bouts of males and their mates prior to and after T treatment. Taken together these data suggest that a rulide penicillin finite incubation period is required for human monocytes to become able to present SLO or SpA to T lymphocytes. Immediate broad-spectrum empirical antibacterial therapy is the key of management in febrile neutropenic patients. Effect of these microbes on nitrogen (N)-metabolism of rice was tested as Typha endophytes were predominantly (N)-fixing. These organic acids are required and cannot be replaced by vitamin mixtures or succinate even though succinate is taken up at a rate similar to that of aspartate, glutamate, and citrate. Second, a more detailed analysis of the publication rates within the international categories is presented.

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All mechanisms responsible for this enhanced PCA of heterostructure what kind of drug is tofranil are elucidated and corresponding models are proposed. Heme-Cu complexes as oxygen-activating functional models for the active site of cytochrome c oxidase. The Svp-3 locus appears tightly linked to Svp-1 on chromosome 2. Efficacy of high therapeutic doses of iodine-131 in patients with differentiated thyroid cancer and detectable serum thyroglobulin. Supraventricular conduction abnormalities following cardiac operations. It is hoped that this information will lead to additional investigations in this burgeoning field and improve our understanding of the novel role fibrocytes may play in human disease. We report that activation of telomerase activity may overcome both inhibitory pathways. Cooperative effects of hydrogen, lithium and halogen bonding on F-H/LiOH2 complexes. CALR mutations were frequent in Chinese patients with ET, especially in those without JAK2 or MPL mutations.

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Larvae survived longer when the density was higher, or the size of a cluster was larger, or both. A note on the estimation of nitrogen retention in chicks by body analysis and balance methods. A novel and effective treatment is urgently needed to deal with the current treatment dilemma in incurable differentiated thyroid cancer (DTC), poorly differentiated thyroid cancer (PDTC) and anaplastic thyroid cancer (ATC). Monoclonal antibodies 3A1, 4F2, 5E9, OKT3, OKT6, and OKT8 were tested by flow microfluorometry for reactivity with cells from patients with T-cell or null cell acute lymphocytic leukemia (ALL). Ultrasonography is the first choice for screening patients with suspected liver lesions. Eye tracking dysfunction unrelated to clinical state and treatment with haloperidol.

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We concluded that information on many of the essential items required for a correct interpretation of the anatomopathologic examination was missing from the request forms. The configuration of the delta, gamma and beta TCR genes and IgH genes was studied using appropriate DNA probes in 12 patients previously diagnosed as having T-cell chronic leukaemia. Abstracts submitted for the annual meeting, the Canadian Society for Clinical Investigation. A dual CD system containing an anionic and a neutral CD in phosphate buffer at acid pH showed a high resolving power allowing the enantiomeric separation of 18 protein amino acids and Orn. Although both the RTA and the HRT give additional information to clinically evaluate macular diseases, they do have limitations. In laboratory rodents, caloric restriction (CR) retards several age-dependent physiological and biochemical changes in skeletal muscle, including increased steady-state levels of oxidative damage to lipids, DNA, and proteins.

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Evolving a research agenda for health care education and training. Most sensory neurons expressing the OR111-7 transgene project to a specific location within the bulb, the central zone protoglomerulus, while a smaller number project to the lateral glomerulus 1 protoglomerulus. Insurance benefits, out-of-pocket payments, and the demand for medical care. A 44-year-old man began to experience episodes of joint pain with erythema in his knees, elbows, shoulders, and hands in April 1996. These results demonstrated that heat shock protein 70 might play an important role as a molecular chaperone during reparative dentin formation. And decreased the contents of lipid classes, proteins, glutathione and the ascorbic acid in various rat brain regions. Increased CDC20 expression is associated with pancreatic ductal adenocarcinoma differentiation and progression. The risk of metachronous cancers in patients with small-intestinal carcinoid tumors: a US population-based study. As rennin is resistant to ultrasound treatment and enhanced temperatures, ultrasound extraction results in a significant increase in the yield and activity.

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The Prodromal Questionnaire: a case for IRT-based adaptive testing of psychotic experiences?. ADA-state program offers intensive training for food service supervisors. Incentive compensation provides two advantages for the healthcare organization--it provides a mechanism to maximize organizational productivity and it gives executives a means to achieve greater compensation. These results speak in favor of using a fluorescence film of minimum diffraction-limited thickness at the lenslet back focal plane. Although novel targeted therapies for metastatic renal cell carcinoma (RCC) are emerging, metastasectomy still remains the only potentially curable intervention and plays an important role both in disease control, cancer-specific survival (CSS) and overall survival (OS). oxalicum AHU-8336) that were found to be excellent strains for a new type of acid carboxypeptidase production in a surface koji culture at 25 C. Myotonic dystrophy protein kinase (DMPK) and Rho-kinase are related. Provision of dental care for medically compromised children in the UK by General Dental Practitioners.

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Ocular infection with HSV-1 continues to be a serious clinical problem despite the availability of effective antivirals. A modified simulation procedure based on a statistical approach was investigated. Localization of mRNAs for six ARFs (ADP-ribosylation factors) in the brain of developing and adult rats and changes in the expression in the hypoglossal nucleus after its axotomy. Plasmacytoid lasix 80 mg daily dendritic cells (PDC) are major producers of type I interferons (IFN) in response to human immunodeficiency virus type 1 (HIV-1) infection. A new continuous perfusion technique for thecultivation of malaria parasites in vitro. We used the data from the only EQ-5D valuation in Poland (2008, three-level, 321 respondents, 23 states each)-a very religious, mostly Catholic country. With these new materials, truly 2D physics has begun to appear (for instance, the absence of long-range order, 2D excitons, commensurate-incommensurate transition, etc.).

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Plasma-derived and recombinant C1-INHs, the bradykinin receptor blocker icatibant, and the plasma kallikrein inhibitor ecallantide have been approved for on-demand treatment to reverse angioedema symptoms. This phenomenon was the result of the parallel alteration in cortisone-sensitivity and the cell function by respective thymocyte subpopulations. A female patient with an extra chromosome 13 (Patau syndrome) is described. Problems in the application of the three-step BCR sequential extraction to low amounts of sediments: an alternative validated route. It was found that the impairment of either the metrics or dynamics of visual and memory saccades did not significantly vary with the different eye positions. Sealant retention in both fluoridated and non-fluoridated teeth was evaluated at 6, 12, and 18 month intervals. To analyse the severity of these conditions as regards the means required for their resolu-tion, as well as to identify the factors that influence on post-operative morbidity in the obstetric patient. The microflora and concentrations of volatile fatty acids in the rumen of cattle fed on single component rations.

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