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Glucotrol (Glipizide)
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Glucotrol

Glucotrol is in a drug class known as sulfonylureas. Sulfonylureas work by telling your pancreas to release insulin, which lowers your blood sugar. Glucotrol tells your pancreas to increase the amount of insulin it produces in your body. Insulin works to lower your blood sugar.

Other names for this medication:
Actizide, Bimode, Diabizide, Diaglip, Dibimet, Dibizide, Glicept, Glimet, Glipicon, Glipid, Glipimet, Glipiriv, Glipitis, Glipixor, Glipized, Glipizide, Glipmet, Gluconil, Glumin, Glycind, Glydal, Glylin, Glysar, Glytop, Gpzide, Metglib, Tranase

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Also known as: Glipizide

Description

Glipizide is used to treat high blood sugar levels caused by a type of diabetes mellitus (sugar diabetes) called type 2 diabetes. In type 2 diabetes, your body does not work properly to store excess sugar and the sugar remains in your bloodstream. Chronic high blood sugar can lead to serious health problems in the future.

Proper diet is the first step in managing type 2 diabetes, but often medicines are needed to help your body. Glipizide belongs to a class of drugs called sulfonylureas. It stimulates the release of insulin from the pancreas, directing your body to store blood sugar. This helps lower blood sugar and restore the way you use food to make energy.

This medicine is available only with your doctor's prescription.

Dosage

This section provides information on the proper use of a number of products that contain glipizide. It may not be specific to Glucotrol XL. Please read with care.

Follow carefully the special meal plan your doctor gave you. This is the most important part of controlling your condition, and is necessary if the medicine is to work properly. Also, exercise regularly and test for sugar in your blood or urine as directed.

This medicine comes with a patient information insert. Read and follow the instructions in the insert carefully. Ask your doctor if you have any questions.

Swallow the extended release tablet whole. Do not split, crush, or chew it.

If you are taking the extended release tablet, part of the tablet may pass into your stool after your body has absorbed the medicine. This is normal and nothing to worry about.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For type 2 diabetes: For oral dosage form (extended-release tablets): Adults—At first, 5 milligrams (mg) once a day taken with breakfast. Your doctor may adjust your dose if needed. The dose is usually not more than 20 mg per day. Children—Use and dose must be determined by your doctor. For oral dosage form (tablets): Adults—At first, 5 milligrams (mg) once a day taken at least 30 minutes before breakfast. Your doctor may adjust your dose if needed. The dose is usually not more than 40 mg per day. Children—Use and dose must be determined by your doctor.

Overdose

If you overdose Glucotrol and you don't feel good you should visit your doctor or health care provider immediately. Symptoms of Glucotrol overdosage: hunger, nausea, anxiety, cold sweats, weakness, drowsiness, unconsciousness, coma.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Detailed Glucotrol XL dosage information

Side effects

The most common side effects associated with Glucotrol are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Do not take Glucotrol if you are allergic to Glucotrol components. Be careful with Glucotrol if you're pregnant or you plan to have a baby, or you are a nursing mother. Be careful with Glucotrol if you have kidney disease, liver disease, thyroid disease, type 1 diabetes, serious infection, illness, or injury. Be careful with Glucotrol if you take aspirin or another salicylate such as magnesium/choline salicylate (Trilisate), salsalate (Disalcid, others), choline salicylate (Arthropan), magnesium salicylate (Magan) or bismuth subsalicylate (Pepto-Bismol); nonsteroidal anti-inflammatory drug (NSAID) such as ibuprofen (Motrin, Advil, Nuprin, others), ketoprofen (Orudis, Orudis KT, Oruvail), diclofenac (Voltaren, Cataflam), etodolac (Lodine), indomethacin (Indocin), nabumetone (Relafen), oxaprozin (Daypro), naproxen (Anaprox, Naprosyn, Aleve) and others; sulfa-based drug such as sulfamethoxazole-trimethoprim (Bactrim, Septra), sulfisoxazole (Gantrisin), or sulfasalazine (Azulfidine); monoamine oxidase inhibitor (MAOI) such as isocarboxazid (Marplan), tranylcypromine (Parnate) or phenelzine (Nardil); beta-blocker such as propranolol (Inderal), atenolol (Tenormin), acebutolol (Sectral), metoprolol (Lopressor) and others; diuretic (water pill) such as hydrochlorothiazide (HCTZ, Hydrodiuril), chlorothiazide (Diuril) and others; steroid medicine such as prednisone (Deltasone, Orasone, others), methylprednisolone (Medrol, others), prednisolone (Prelone, Pediapred, others) and others; phenothiazine such as chlorpromazine (Thorazine), fluphenazine (Prolixin, Permitil), prochlorperazine (Compazine), promethazine (Phenergan) and others; phenytoin (Dilantin); isoniazid (Nydrazid); prescription, over-the-counter, or herbal cough, cold, allergy or weight loss medications. Avoid alcohol. Do not stop taking Glucotrol suddenly.

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Achieving this level of control over the interfacial structure requires transformational advances in three complementary research disciplines: (1) the scope of organic reactions that can be successfully carried out on surfaces must be increased, (2) lithography tools are needed that are capable of positioning soft organic and biologically active materials with sub-1 micrometer resolution over feature diameter, feature-to-feature spacing, and height, and (3) new techniques for characterizing the 4D structure of interfaces should be developed and validated. Airborne fine particulate matter alters the expression of endothelin receptors in rat coronary arteries. New clinical practice guidelines for the treatment of low back pain were published in the April 2012 issue of JOSPT. Our findings offer insight regarding the influencing factors of early retirement intentions in nurses. Coding regions of 18 candidate genes were screened with PCR and Sanger sequencing. PREPARATION AND CHEMICAL PROPERTIES OF PURIFIED STEM AND FRUIT BROMELAINS. Bulimic-type eating pathology among girls was associated with early menarche, early sexual experiences, and increasing age. After finishing each canal preparation, the instruments accompanied by control were examined under the stereomicroscope by an inspector without knowing the group. The absorption characteristics of three different Strontium Tartrate crystals viz.

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Organic nitrogen uptake is a significant contributor to nitrogen economy of subtropical epiphytic bryophytes. Differences in pain location (ADD side versus contralateral side) and in the bite force thresholds for eliciting pain or discomfort were assessed by means of the paired t test and Wilcoxon signed-rank test. Regional changes in cerebral blood volume moduretic 50 mg during mental activity. The main actual dose was 28 U/kg/h, and the mean predicted dose was 25.8 U/kg/h. Here we report the results of three studies conducted in Poland, the Czech Republic and Hungary that provide additional evidence for the beneficial effects of combining trimetazidine with a conventional haemodynamic agent such as beta-blockers, long-acting nitrate or calcium channel blockers. A questionnaire was delivered to patients willing to take part, at a regular visit to their ophthalmologist, for filling in anonymously at home. To gain insight into the solvatochromic behavior of these compounds, the dependence of the spectra on solvent polarity was studied on the basis of Lippert-Mataga models. An epidemiological early warning system for malaria control in northern Thailand. Proceedings: The relationship to age of indices of leg muscle and estimated fat-free mass in adult females.

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Simple and efficient model systems of screening anti-Toxoplasma drugs in vitro. Final hits are evaluated through customizable scoring functions. Comparison of the free and bound forms by x-ray crystallography, small angle x-ray scattering, and chemical probing reveals almost identical structures, indicating diamox dosing renal failure that lysine induces only limited and local conformational changes upon binding. Determination of phospholipids in olive oil by 31P NMR spectroscopy. The level of neurotransmitters (DA, 5-HT, NA) and their metabolites (DOPAC, HVA, 5-HIAA) was analyzed by HPLC with coulochemical detection. Results indicate the subjects achieved age equivalent scores significantly closer to their chronological ages on the PPVT-R.

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Body image reintegration and coping effectiveness after head and neck surgery: a review. The spectrum of mutations in the Arabic population is partially studied. To evaluate magnesium as a sole or adjuvant agent with currently used prophylactic drugs in suppressing postoperative atrial tachyarrhythmias (POAT) after coronary artery bypass graft (CABG) surgery. The recent ultram brand discontinued identification of pre-existing IgE crossreacting with cetuximab, its association with severe reactions, and regional variation in the prevalence may provide a marker for high-risk assessment. There is insufficient evidence to determine the ability of ACPs to return safely to anesthesia practice after rehabilitation, though awareness of the issue and ongoing treatment are necessary to minimize patient risk from potentially related clinical errors. The object of this study was thus to investigate if pindolol augments the antidepressant response to venlafaxine. Stroke-Unit and emergency medical service: a 48-month experience in northern Italy. However, limited clinical activity of bortezomib has been observed in many epithelial malignancies, suggesting this could result from incomplete inhibition of NF-kappaB/RELs or other prosurvival signal pathways. Endometrial patterns and endocrinologic characteristics of asymptomatic menopausal women.

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Alternative splicing of the three zmbnl primary transcripts gives rise to at least four protein isoforms for zmbnl1, four for zmbnl2 and five for zmbnl3, respectively. Evaluating the effectiveness of smoking cessation in the management of COPD. The age-related changes in the liver oxidative status of glutathione, lipid peroxidation, and the activity of the enzymatic antioxidant defense system, as well as the influence of aging on the susceptibility to the hepatotoxic effects of cyclosporin (CyA) were investigated in rats of different ages (1, 2, 4, and 24 months). Laboratory investigations revealed elevation at transaminases levels, hypoalbuminemia, hypergammaglobulinemia, presence of autoantibodies and eosinophilia. We provide simulations that (1) validate our model against behavioral, experimental results in tasks where the participants were asked to report common or separate causes for cross-modal stimuli presented with arbitrary spatial and temporal disparities. The paper indicates that there are numerous grounds for believing that both kinds of data are flawed at their points of origin, and that the transformations which the data undergo during coding procedures leads to further distortions of our image of mortality and its social base. This platform was interfaced to a commercial EIS instrument through an automated electronic switching unit. Data gaps in planning for comprehensive fertility-related health services. Patient was able to move around in a wheelchair on the sixth postoperative day. Primary infection with HSV-1 can involve ocular and adenaxial sites and can manifest as blepharitis, conjunctivitis, or corneal epithelial keratitis.

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To assess the morbidity, mortality and 1- and 2-year survival rates, and safety of pancreaticoduodenectomy for periampullary (including pancreatic head) carcinomas in a non-oncology surgical set-up. Corrigendum: Dynamic expression of long noncoding RNAs and repeat elements in synaptic plasticity. The results of a European survey amongst 722 general practitioners, rheumatologists, orthopaedic surgeons and internal specialists showed that about half of all patients treated for moderate-to-severe pain suffered from musculoskeletal pain. The aim of the study was to establish indications for operative vaginal delivery by extraction of the fetus with forceps in modern obstetrics. Our findings demonstrate that HBZ utilizes a bipartite mechanism to repress viral transcription.

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Buschke -Loewenstein tumor: identification of HPV type 6 and 11. pylori infection, human gastric epithelial cells were incubated with H. Efficacy and safety of tribendimidine against Opisthorchis viverrini: two randomised, parallel-group, single-blind, dose-ranging, phase 2 trials. Clustering and fluidization in a one-dimensional granular system: molecular dynamics and direct-simulation Monte Carlo method. Hendra virus (HeV) and Nipah virus (NiV) form a separate genus Henipavirus within the family Paramyxoviridae, and are classified as biosafety level 4 pathogens due to their high case fatality rate following human infection and because of the lack of effective vaccines or therapy. Thus, extinction learning can selectively restore some populations of downregulated mGluRs after prolonged exposure to meth.

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