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Differin (Adapalene)

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Differin and Differin (Retin-A) are different medications, but they are both used to treat mild-to-moderate acne. Differin contains adapalene, and Retin-A contains Differin. They both offer a range of benefits and options, so talk to your healthcare provider to discuss which one would be the best fit for you.

Other names for this medication:
Aclene, Acneril, Acneris, Acniriv, Acnovate, Adaferin, Adapalene, Adapen, Adaple, Adaret, Adgraze, Adiff, Adina, Aditop, Adlene, Alangel, Apalene, Apgel, Clinred, Daple, Deriva, Difra, Edplin, Faceclin, Labopene, Medapine, Rozac, Soflene, Vandep, Zolvee

Similar Products:
Asacol, Urispas, Cytoxan, Aceon, Fulvicin, Hipertensal, Plavix, Escita, Rekof, Sulfoglim,

Also known as: Adapalene


Differin (adapalene) is a topical medicine (a medication that is applied to the surface of the skin) similar to vitamin A. It helps the skin to renew itself.

Differin is used to treat severe acne in people who are at least 12 years old. It works by decreasing acne formation.


Usual Adult Dose for Acne:

Differin 0.1% cream, 0.1% gel, 0.3% gel: Apply to the affected area once a day at bedtime after washing. A thin film should be applied, avoiding eyes, lips, angles of the nose, and mucous membranes. Lotion: Apply a thin film of lotion to the entire face and other affected areas of the skin once daily, after washing gently with a mild soapless cleanser. Dispense a nickel size amount of lotion (3 to 4 actuations of the pump) to cover the entire face. Avoid application to the areas of skin around eyes, lips and mucous membranes.

Usual Pediatric Dose for Acne:

Differin 0.1% cream, 0.1% gel, 0.3% gel: 11 years or less: Safety and efficacy have not been established. 12 to 18 years: Apply to the affected area once a day at bedtime after washing. A thin film should be applied, avoiding eyes, lips, angles of the nose, and mucous membranes. Safety and effectiveness of the lotion formulation in pediatric patients under the age of 12 have not been established.

Detailed Differin dosage information


Seek emergency medical attention if you think you have used too much of this medicine. Overdose symptoms may include skin redness, scaling, or irritation.


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Detailed Differin dosage information

Side effects

The most common side effects associated with Differin are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Do not take Differin if you are allergic to Differin components. It is not known whether Differin will harm an unborn baby. Do not use this medicine without your doctor's advice if you are pregnant or breast-feeding. Do not get Differin in your eyes or on the inside of your nose or mouth. For the first 2 to 3 weeks of treatment, your skin condition may appear to worsen. This is expected. Do not stop using the medicine during this time. Do not use other medicines on your skin without first discussing it with your doctor. While you are using Differin, you may use cosmetics. After using cosmetics, thoroughly wash and dry the affected area before applying this medicine. Avoid exposure to the sun, sunlamps, or tanning booths until you know how you react to Differin. Use a sunscreen if you must be outside. Do not apply it to sunburned skin. Do not stop taking Differin suddenly.

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This study examined the pathobiological effects of arecoline, a major component of the betel nut alkaloids, on human periodontal ligament fibroblasts (PDLF) in vitro. EFFECT OF ALDOSTERONE ON THE INTESTINAL TRANSPORT OF SODIUM AND POTASSIUM IN RATS. These findings establish the existence of early hair follicle SCs and reveal their physiological importance in tissue morphogenesis. The expression of both genes was clearly activated under iron deficiency. From risk to globalization: discursive shifts in the French debate about GMOs.

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The model improves conceptual understanding of the relationship of parameters affecting therapy and makes it possible to optimize radio-immunotherapy by selecting the most effective antibody and radionuclide according to tumour biology. Letter: Acute renal failure due to intentional glafenine poisoning. Anxiety and depression are independent predictors of quality of life of patients with chronic musculoskeletal pain. Knowing the critical velocity (ucrit) of a chromatography column is an important part of process development as it allows the optimization of chromatographic flow conditions. Further studies should evaluate the possible effect of age on treatment outcome. This paper proposed a method for prediction and modelling a chaotic FIR laser time series using rational function neural network. Dual IHC confirmed that expression of p21 was considerably more widespread than p53, consistent with p53-independent expression of p21 in suprabasal keratinocytes in HPV-infected epithelium.

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The gene expression pattern specified by an animal regulatory sequence is generally viewed as arising from the particular arrangement of transcription factor binding sites it contains. A clinical surveillance definition based on concurrent vasopressors, blood cultures, and antibiotics accurately identifies septic shock hospitalizations and suggests that the incidence of patients receiving treatment for septic shock has risen and mortality rates have fallen, but less dramatically than estimated on the basis of ICD-9 codes. At the present time, most computer applications are directed toward (1) the management of large and amounts of data during a short period of time (e.g., ECG analysis and physiological monitoring) or (2) the transfer of information within a facility (e.g., Hospital Information System (HIS) order entry/results reporting). The aim of this study was to assess ROMs production in gastric biopsies of patients infected by H. Although number of pain sites (NPS) is considered highly relevant in pain assessment, little is known regarding the relationship between socioeconomic conditions and NPS. The accuracy of this early UBT was compared to a delayed one after hospital discharge that was considered the gold standard. CYTOLOGY OF CONJUGATION IN PARAMECIUM MULTIMICRONUCLEATUM, SYNGEN 2, STOCK II. Growth and characterization of T cell colonies from human thymus. A family of three-dimensional 3d-4f and 4d-4f heterometallic coordination polymers based on mixed isonicotinate and 2-sulfobenzoate ligands: syntheses, structures and photoluminescent properties. Experiment on formulation and drug release behavior of porosity asymmetric membrane capsules in vitro.

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RESULTS OF A MASS SURVEY OF 14839 WOMEN IN THE PROVINCE OF FERRARA. Auditory brain stem response testing in infants with collapsed ear canals. Chicken spleen and peripheral blood lymphocytes were tested for their ability to produce T cell growth factor (interleukin 2, IL 2) upon stimulation with phytohemaglutinin or concanavalin A (Con A). Poisson multiple regression models were used to assess the impact of host and therapy factors on the risk of developing SMNS: All statistical tests were two-sided. Emulsion stability is enhanced upon decreasing the chain length of the oil due to its increased solubility in the precursor aqueous phase. These observations may help clarify the interpretation of assays for urine mutagenicity in occupational or other environmental studies.

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Luteinizing hormone and growth hormone activity of the human fetal pituitary. A computational model, which was motivated by a recent neuropsychological theory of category learning, successfully accounted for this suboptimal performance in both categorization and identification. Viral clones from the GOS expedition with an unusual photosystem-I gene cassette organization. Acute venous thrombosis of the lower extremities: normal and pathologic phlebography. Clinical aspects and radio-therapy of malignant tumors of the palatine tonsils. Most research to date on why the testing effect occurs has been behavioral, but we employed neuroimaging methods in this study in order to shed light on the underlying processes. Tubulointerstitial and vascular alterations were mild or absent. Enhancement of pentagastrin-induced gastric acid secretion by clonidine in the conscious dog.

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The present study was designed to examine whether the elevation of serum corticosterone (SCS) level induced by naloxone-precipitated morphine withdrawal was a useful index to quantify the physical dependence on morphine in mice, which was compared with body weight loss induced by naloxone-precipitated morphine withdrawal. INTRAPULMONARY VENTILATION DISORDERS IN EMPHYSEMA AND EMPHYSEMA DISEASE. Metal-responsive transcription factor 1 (MTF-1), which binds to metal response elements (MREs), plays a central role in transition metal detoxification and homeostasis. Training program and additional electric muscle stimulation for patellofemoral pain syndrome: a pilot study. Leydig cell proliferation was decreased in the hyperthyroid pups at the age of 15 days and slightly elevated at later ages, suggesting a possible slower zyrtec allergy medicine side effects onset of the proliferative activity of these cells than in the euthyroid control animals. In both gray and white matter, there is a characteristic presence of a few highly stained cells. Autophagy is required for CSF-1-induced macrophagic differentiation and acquisition of phagocytic functions. In vitro alternative and classical activation of complement by extracts of cotton mill dust: a possible mechanism in the pathogenesis of byssinosis. The different effect of thyroidectomy, KClO4 and propylthiouracil on insulin secretion and glucose uptake in the rat. The estimated daily lead intake of breast-fed infants in Malaysia was well below proposed tolerable levels.

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Structural analysis of LUSH(D118A) reveals that it closely resembles cVA-bound LUSH. ITOHealth: a multimodal middleware-oriented integrated architecture for discovering medical entities. The phenomenology of the spin model is similar to that of a supercooled liquid undergoing the glass transition. Previous research suggests that prenatal testosterone affects the 2D:4D finger ratio in humans, and it has been speculated that prenatal testosterone also affects gender identity differentiation. Combination treatment was also shown to enhance reversion of the precore mutation. Conversely, the cozaar drug user reviews different arousal conditions did not affect the cognitive performances of vehicle-treated animals such as the capability to discriminate a spatial displacement of the objects or an object substitution. Targeted therapy for hepatocellular carcinoma: novel agents on the horizon. Skeletal stability of Le Fort I osteotomy in patients with unilateral cleft lip and palate. A fatality in one multiple sclerosis (MS) patient due to acute idiopathic thrombocytopenic purpura (ITP) and a near fatality in another stimulated our interest in platelet function abnormalities in MS.

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Chronic undernutrition throughout pregnancy affects birth weights of newborns. Elevated plasma D-dimer as a predictor of postoperative complications after radical cystectomy. Since overexpression of Rev3 is detrimental for nuclear DNA mutability, we constructed a mutant Rev3 isoform unable to migrate into the nucleus: its overexpression reduced mtDNA mutability without increasing the nuclear one. Over the age of 65 nearly half of the postmenopausal women with osteoporosis have VF and a higher prevalence of low 25(OH)D serum measurements. Metabolism of fast-labled RNA in HeLa cells, synchronised by gamma rays in the S period. Further biochemical and pharmacological studies are in progress. For both kinds of signal we show that the transmission by the ensemble reveals stochastic resonance as well as a nonmonotonous dependence on the driving frequency. Oxyproline, uric acid and copper oxidase content of blood in children and adolescents with rheumatism.

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Porphyric enzymes in hamster Harderian gland, a model of damage by porphyrins and their precursors. The aim of this study was to identify how women use the Internet as a source of information during their pregnancy and how it affects them. Damage was detected in WBC after exposure to 10-50 microM tin(II) for 30 min at either 0 degree or 37 degrees C. There is very little information available in the literature concerning orthopaedic training programmes worldwide. Novel murine tumour models depend on strain and route of inoculation. Recombinant activated factor VII, a bypassing hemostatic agent originally developed for the treatment of hemorrhages in hemophilic patients with inhibitors, is increasingly being employed on a compassionate use basis for the treatment of uncontrolled massive bleeding from various causes. In CV-1 cells (monkey kidney fibroblast), the Type I ortho ester-based lipoplexes, especially those with the chloride counterion, significantly improved the gene transfection efficiency, in some cases by more than 100 fold, compared to their pH-insensitive counterparts consisting of DOTAP.

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