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Biproate (Divalproex)

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Biproate is used to treat seizure disorders, certain psychiatric conditions (manic phase of bipolar disorder), and to prevent migraine headaches. It works by restoring the balance of certain natural substances (neurotransmitters) in the brain.

Other names for this medication:
Devot, Dicorate, Diproex, Discern, Divalin, Divalproex, Divalrate, Drvel, Epilex, Jydival, Kayval, Nepilex, Torvate, Trival, Valance, Valate, Valcontin, Valcot, Valpex, Valporate, Valporil, Valporiv, Valporl, Valpret, Valprid, Valric, Valtaril, Valtec, Valver, Valvo, Velpo, Velze, Vinchorate, Zorat, Zoret

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Also known as: Divalproex


Biproate Sprinkles comes in different pill forms that are for different uses.

Biproate Sprinkles tablets and capsules are used to treat seizures in people with epilepsy who are at least 10 years old. This medicine tablets are sometimes used together with other seizure medications.

Biproate Sprinkles tablets are also used in adults to prevent migraine headaches, or to treat manic episodes related to bipolar disorder (manic depression).


This section provides information on the proper use of a number of products that contain valproic acid. It may not be specific to Biproate DR. Please read with care.

Take this medicine exactly as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered.

This medicine comes with a Medication Guide or patient information leaflet. Read and follow the instructions carefully. Ask your doctor if you have any questions.

Swallow the delayed-release capsules or oral capsules whole with a full glass of water. Do not split, crush, or chew it. You may take this medicine with food to decrease stomach upset.

If you cannot swallow the capsule whole, you may open it and sprinkle the contents onto a small amount of soft food (including applesauce or pudding).

Measure the oral liquid medicine with a marked measuring spoon, oral syringe, or medicine cup.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For oral dosage forms (capsules, delayed-release capsules, and solution): For seizures: Adults and children 10 years of age or older—Dose is based on body weight and must be determined by your doctor. At first, the usual dose is 10 to 15 milligrams (mg) per kilogram (kg) of body weight per day. Your doctor may gradually increase your dose every week by 5 to 10 mg per kg of body weight as needed. However, the dose is usually not more than 60 mg per kg of body weight per day. If the total dose a day is greater than 250 mg, it is usually divided into smaller doses and taken 2 or more times during the day. Children younger than 10 years of age—Use and dose must be determined by your doctor. For oral dosage form (delayed-release capsules): For mania: Adults—At first, 750 milligrams (mg) once a day, usually divided in smaller doses. Your doctor may increase your dose as needed. Children—Use and dose must be determined by your doctor. For migraine: Adults—At first, 250 milligrams (mg) 2 times a day. Your doctor may increase your dose as needed. However, the dose is usually not more than 1000 mg a day. Children—Use and dose must be determined by your doctor.


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Detailed Valproic acid dosage information

Side effects

The most common side effects associated with Biproate are:

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Blockade of stress-induced apoptosis of MDMs treated with HIV-1 Nef resulted from enhanced nucleocytoplasmic transport of eEF1A with decreased release of mitochondrial cytochrome c, and from increased tRNA binding to cytochrome c, ultimately leading to an inhibition of caspase activation. Effects of lipid dysmetabolism in rats induced by high fat diet on glycometabolism and inflammatory factor. Alpha-toxins from scorpion venoms prolong the action potential of excitable cells by blocking sodium channel inactivation. The insect cell line BTI-TN-5B1-4 (High Five) is frequently used to express recombinant proteins in large amounts using the baculovirus expression system. When the relative oxygen uptake rate was high, enhanced yields of acetate and acetoin were noted.

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This conceptual difficulty may be largely explained in terms of the symbolism involved in clean and dirty water and the life-giving quality of water. To assess the contribution of MRI and proton spectroscopy (1HMRS) in establishing an etiological diagnosis in children with developmental delay (DD) and to assess whether the chance of finding specific abnormalities correlates with the presence of neurological signs and/or abnormal head circumference (HC). In the case of RNA polymerase II-transcribed genes, cotranscriptional processes such as mRNA maturation, splicing, and export influence the integrity of replication forks and transcribed loci. We retrospectively examined the predictive value of 20 demographic, clinical, biochemical and endocrinological variables using a two-step logistic regression. Aortic intramural hematoma type B: images of an entity with different evolution pathways. Discordances between the observed and the theoretical molecular masses of several proteins suggested the presence of protein glycosylation, corroborated with specific glycoprotein staining after protein de-glycosylation using trifluoromethanesulfonic acid.

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Constitutive over-expression of rice ClpD1 protein enhances tolerance to salt and desiccation stresses in transgenic Arabidopsis plants. Comparative molecular dynamics simulations of the potent synthetic classical cannabinoid ligand AMG3 in solution and at binding site of the CB1 and CB2 receptors. The observations suggest that osteoclast-like cells differentiate from mononuclear precursor cells of hematopoietic tissue. The incidence of cancer has been staying at a high level worldwide in recent years. Deprotonation of hydrochloride salts of amino acid esters and peptide esters using commercial zinc dust. Tuberculosis is one of the major causes of ill health and death worldwide. Analogous allometrically scaled variables were used to account for leg length differences. The present study suggests that erosive OLP may develop anti-Dsg3 autoantibodies, which should be carefully assessed.

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ACD BLOOD TRANSFUSIONS: VOLUME DETERMINATIONS AND ELECTROLYTE CHANGES. Our results thus show that automated MLPA data processing following our suggested strategy may be of significant use, especially when handling large MLPA data sets, when samples are of different quality, or interpretation of MLPA electropherograms is too complex. Fearful individuals often overestimate the relationship between fear-relevant stimuli and aversive consequences. The present study was, therefore, initiated to examine T cell-mediated immunity to influenza virus in aged mice. Chronic myelomonocytic leukemia with antecedent refractory anemia with excess blasts: further evidence for the arbitrary nature of current classification systems. With miniaturized tube lenses and a micro-electro-mechanical system (MEMS) mirror, we constructed a miniaturized multiphoton microscope system. According to the cue-belief model, biased instructions send a positive accuracy cue regarding the most familiar-looking lineup member. Covariation of EDP and arterial blood pressure (BP) should be regarded as a warning sign, especially if it is pronounced or appears during the postoperative course. In conclusion, ER and stathmin were independent predictive factors for NCT with docetaxel-containing regimens. A dual-modality probe for positron-emission tomography (PET) and fluorescence imaging was synthesized using the developed BaAn(Boc)Sar chelator.

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CYTOLOGICAL CHARACTERISTICS OF THE DEVELOPMENT OF 3 STRAINS OF ACT. However its role in emergency situations like status epilepticus (SE) is still not clear. Case cart activation: a matrix management approach for planning and implementation. The ratio of mean private to NHS income for consultants employed on a full-time contract was 0.26. For the first time it is shown that SIRT2 directs mitochondrial metabolism. On the optimal control of fed-batch reactors with substrate-inhibited kinetics. Chloroplast RNA is synthesized in dark-grown radish cotyledons at about one-third the rate of that in the light. Phospholipid analysis and fatty acid content in platelets by the combination of high-performance liquid chromatography and glass capillary gas--liquid chromatography. In view of the fact that periprosthetic remodeling takes place during the first 6-12 months after surgery and is ultimately responsible for prosthesis longevity, we may conclude that the administration of high dosage ibandronate postsurgery by IV bolus and subsequently as cyclic oral treatment reduced cortical osteopenia in the metaphyseal region, and in the calcar region of the proximal femur. Proteins adsorbed to the materials were analysed by sodium dodecyl sulphate-polyacrylamide gel electrophoresis and results evidenced that the two glass-coated materials bound a higher amount of total protein than did the zirconia substrate.

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Observed mathematically significant differences between the enzyme activity in the blood of male and females were probably of little physiological significance. In contrast to being a trait marker in schizophrenia and depressive disorder, plasma sIL-2R levels may be considered a biological indicator of manic severity in a group of bipolar affective patients. The number of porphyrin molecules on the surface of a single CdSe nanoparticle increased with increasing reaction time to reach a saturated maximum of 21. It is concluded that ultrasound scanning of the liver is essential for early diagnosis and that the treatment of choice is percutaneous needle aspiration in combination with bactericidal antibiotics. Cerebellar granule neurons (CGN) cultured in the presence of serum and depolarizing potassium concentrations undergo apoptosis when switched to serum-free medium containing physiological potassium concentrations. NONHSAG013805 (down-regulated) and NONHSAG009271 (down-regulated) were common lncRNAs. The role of a sex-limited blood protein in egg formation by the Cecropia silkworm. Although Cdt1 is known to be essential for loading of Mcm onto the chromatin, its precise role in pre-RC formation and replication initiation is unknown. Trials on timing of thromboprophylaxis have been designed primarily to detect thrombotic events, and it has been difficult to interpret the magnitude of blood loss and bleeding events owing to lack of information for bleeding volume and underpowered bleeding end points.

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GPS tracking for a full day was feasible, although significant efforts are needed to impute missing data. These data show that EGF contributes to the differentiation and migration of myofibroblasts induced by TGF-beta1 through EGF-R activation and that it is an important modulator of wound healing and scar tissue formation. Spontaneous metastases from the UV-2237M-ADMR tumor commonly retained resistance to ADM. The metabolic rate of oxaprozin in rats is 3.5 and 7.2 times more rapid than in mice and dogs, respectively, and its blood level in rats is low. PUBLIC HEALTH VIEWS ITS SHARED RESPONSIBILITIES FOR SCHOOL HEALTH. Our study indicates that family function has an important influence on caregiver burden. Mortality and morbidity among the working population of anthophyllite asbestos miners in Finland.

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