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Biproate (Divalproex)
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Biproate

Biproate is used to treat seizure disorders, certain psychiatric conditions (manic phase of bipolar disorder), and to prevent migraine headaches. It works by restoring the balance of certain natural substances (neurotransmitters) in the brain.

Other names for this medication:
Devot, Dicorate, Diproex, Discern, Divalin, Divalproex, Divalrate, Drvel, Epilex, Jydival, Kayval, Nepilex, Torvate, Trival, Valance, Valate, Valcontin, Valcot, Valpex, Valporate, Valporil, Valporiv, Valporl, Valpret, Valprid, Valric, Valtaril, Valtec, Valver, Valvo, Velpo, Velze, Vinchorate, Zorat, Zoret

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Also known as: Divalproex

Description

Biproate Sprinkles comes in different pill forms that are for different uses.

Biproate Sprinkles tablets and capsules are used to treat seizures in people with epilepsy who are at least 10 years old. This medicine tablets are sometimes used together with other seizure medications.

Biproate Sprinkles tablets are also used in adults to prevent migraine headaches, or to treat manic episodes related to bipolar disorder (manic depression).

Dosage

This section provides information on the proper use of a number of products that contain valproic acid. It may not be specific to Biproate DR. Please read with care.

Take this medicine exactly as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered.

This medicine comes with a Medication Guide or patient information leaflet. Read and follow the instructions carefully. Ask your doctor if you have any questions.

Swallow the delayed-release capsules or oral capsules whole with a full glass of water. Do not split, crush, or chew it. You may take this medicine with food to decrease stomach upset.

If you cannot swallow the capsule whole, you may open it and sprinkle the contents onto a small amount of soft food (including applesauce or pudding).

Measure the oral liquid medicine with a marked measuring spoon, oral syringe, or medicine cup.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For oral dosage forms (capsules, delayed-release capsules, and solution): For seizures: Adults and children 10 years of age or older—Dose is based on body weight and must be determined by your doctor. At first, the usual dose is 10 to 15 milligrams (mg) per kilogram (kg) of body weight per day. Your doctor may gradually increase your dose every week by 5 to 10 mg per kg of body weight as needed. However, the dose is usually not more than 60 mg per kg of body weight per day. If the total dose a day is greater than 250 mg, it is usually divided into smaller doses and taken 2 or more times during the day. Children younger than 10 years of age—Use and dose must be determined by your doctor. For oral dosage form (delayed-release capsules): For mania: Adults—At first, 750 milligrams (mg) once a day, usually divided in smaller doses. Your doctor may increase your dose as needed. Children—Use and dose must be determined by your doctor. For migraine: Adults—At first, 250 milligrams (mg) 2 times a day. Your doctor may increase your dose as needed. However, the dose is usually not more than 1000 mg a day. Children—Use and dose must be determined by your doctor.

Overdose

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Detailed Valproic acid dosage information

Side effects

The most common side effects associated with Biproate are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

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Blockade of stress-induced apoptosis of MDMs treated with HIV-1 Nef resulted from enhanced nucleocytoplasmic transport of eEF1A with decreased release of mitochondrial cytochrome c, and from increased tRNA binding to cytochrome c, ultimately leading to an inhibition of caspase activation. Effects of lipid dysmetabolism in rats induced by high fat diet on glycometabolism and inflammatory factor. Alpha-toxins from scorpion venoms prolong the action potential of excitable cells by blocking sodium channel inactivation. The insect cell line BTI-TN-5B1-4 (High Five) is frequently used to express recombinant proteins in large amounts using the baculovirus expression system. When the relative oxygen uptake rate was high, enhanced yields of acetate and acetoin were noted.

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This conceptual difficulty may be largely explained in terms of the symbolism involved in clean and dirty water and the life-giving quality of water. To assess the contribution of MRI and proton spectroscopy (1HMRS) in establishing an etiological diagnosis in children with developmental delay (DD) and to assess whether the chance of finding specific abnormalities correlates with the presence of neurological signs and/or abnormal head circumference (HC). In the case of RNA polymerase II-transcribed genes, cotranscriptional processes such as mRNA maturation, splicing, and export influence the integrity of replication forks and transcribed loci. We retrospectively examined the predictive value of 20 demographic, clinical, biochemical and endocrinological variables using a two-step logistic regression. Aortic intramural hematoma type B: images of an entity with different evolution pathways. Discordances between the observed and the theoretical molecular masses of several proteins suggested the presence of protein glycosylation, corroborated with specific glycoprotein staining after protein de-glycosylation using trifluoromethanesulfonic acid.

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Constitutive over-expression of rice ClpD1 protein enhances tolerance to salt and desiccation stresses in transgenic Arabidopsis plants. Comparative molecular dynamics simulations of the potent synthetic classical cannabinoid ligand AMG3 in solution and at binding site of the CB1 and CB2 receptors. The observations suggest that osteoclast-like cells differentiate from mononuclear precursor cells of hematopoietic tissue. The incidence of cancer has been staying at a high level worldwide in recent years. Deprotonation of hydrochloride salts of amino acid esters and peptide esters using commercial zinc dust. Tuberculosis is one of the major causes of ill health and death worldwide. Analogous allometrically scaled variables were used to account for leg length differences. The present study suggests that erosive OLP may develop anti-Dsg3 autoantibodies, which should be carefully assessed.

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This review focuses on the microenvironmental features of articular cartilage and how they influence stem cell-based cartilage tissue repair. Measurement of free and complexed soluble vascular endothelial growth factor receptor, Flt-1, in fluid samples: development and application of two new immunoassays. The use of low-density lipoprotein cholesterol (LDL-C)-lowering medications has led to a significant reduction of cardiovascular risk in both primary and secondary prevention. ET-1, C-terminal fragment (CTF), big ET-1, and atrial natriuretic peptide (ANP) were measured. THE RELATIONSHIP BETWEEN ATTRITIONAL FACETS AND THE OCCLUSAL PLANE IN ABORIGINAL AUSTRALIANS. Arsenic (AS) is a reactive oxygen species (ROS)-inducer carcinogen, whose mode of action is still unclear. Toxicity was evaluated by lethality in mice and hemolysis test from human erythrocytes and the experimental AMB formulations were compared with reference formulations of AmBisome, Fungizone and heated Fungizone. Limitations of this study include the lack of direct interviewing of probands and the limited number of ADHD/BPD probands available. Improving service through patient surveys in a multihospital organization.

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Data were analyzed by nonparametric and parametric statistical tests. Center for first aid and medical care of radiation-contaminated and radiation-injured patients. Boxing, weight-lifting, wrestling, and judo are graded events in that opponents are matched by weight. The objective of this study was to evaluate the clinical benefits of routine squamous cell carcinoma antigen (SCC-Ag) monitoring of patients with locally advanced cervical squamous cell carcinoma treated with radiation or chemoradiation. As a faculty member at a community college that transmits all lecture courses to a distant site, the author provides a step-by-step guide for implementing videoconferencing.

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Matching-to-sample procedures were used to train 12 paired associates from among 24 stimuli. Integration of balance-related cues from the vestibular and other sensory systems requires that they be perceived simultaneously despite arriving asynchronously at the central nervous system. The ability to modulate transcription factor activity is critically important for deciphering many cellular and developmental processes. Whereas nontransgenic HDL protected against oxidized LDL induction of adhesion molecules in endothelial cells, HDL from apoA-II transgenic mice was proinflammatory. Copeptin, a stable peptide derived from the vasopressin precursor, correlates with the individual stress level. The distribution patterns of total protein and protein components in different layers of wheat grain were investigated using the pearling technique, and the sources of different protein components and pearling fractions were identified using (15)N isotope tracing methods. Molecular heterogeneity of inherited antithrombin III deficiency. We predict that by simply including an inductor and capacitor in the photodetector circuit with the properly chosen values, detector bandwidths can be as much as doubled, with no undesired effects.

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The cellular uptake and cytotoxicity studies of these NPs in different human cancer lines, namely, human colorectal carcinoma cell line HCT116 and human breast cancer cell line MCF-7 demonstrated dose dependent cytotoxicity. Understanding the solid-state behaviour of triglyceride solid lipid extrudates and its influence on dissolution. Effects of RNA interference targeting hypoxia-inducible factor-1alpha (HIF-1alpha) on chemosensitivity of leukemia K562 cells towards homoharringtonine. Physicochemical features of hemoglobin of the crustacean, Triops longicaudatus. Then, the expression for the energy and the differential equation for the phase allow a solution in terms of quadratures. Arrhythmogenic right ventricular dysplasia/cardiomyopathy in a Siberian husky. Inhibition of mitochondrial protein synthesis promotes autonomous regulation of mtDNA expression and generation of a new mitochondrial RNA species. Trypsinogen activation peptides, acinar cell necrosis, and PCBF were used as local indicators of disease severity, fluid sequestration, cardiorespiratory and renal parameters, and colonic capillary blood flow as systemic disease indicators.

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CYTOLOGICAL CHARACTERISTICS OF THE DEVELOPMENT OF 3 STRAINS OF ACT. However its role in emergency situations like status epilepticus (SE) is still not clear. Case cart activation: a matrix management approach for planning and implementation. The ratio of mean private to NHS income for consultants employed on a full-time contract was 0.26. For the first time it is shown that SIRT2 directs mitochondrial metabolism. On the optimal control of fed-batch reactors with substrate-inhibited kinetics. Chloroplast RNA is synthesized in dark-grown radish cotyledons at about one-third the rate of that in the light. Phospholipid analysis and fatty acid content in platelets by the combination of high-performance liquid chromatography and glass capillary gas--liquid chromatography. In view of the fact that periprosthetic remodeling takes place during the first 6-12 months after surgery and is ultimately responsible for prosthesis longevity, we may conclude that the administration of high dosage ibandronate postsurgery by IV bolus and subsequently as cyclic oral treatment reduced cortical osteopenia in the metaphyseal region, and in the calcar region of the proximal femur. Proteins adsorbed to the materials were analysed by sodium dodecyl sulphate-polyacrylamide gel electrophoresis and results evidenced that the two glass-coated materials bound a higher amount of total protein than did the zirconia substrate.

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Observed mathematically significant differences between the enzyme activity in the blood of male and females were probably of little physiological significance. In contrast to being a trait marker in schizophrenia and depressive disorder, plasma sIL-2R levels may be considered a biological indicator of manic severity in a group of bipolar affective patients. The number of porphyrin molecules on the surface of a single CdSe nanoparticle increased with increasing reaction time to reach a saturated maximum of 21. It is concluded that ultrasound scanning of the liver is essential for early diagnosis and that the treatment of choice is percutaneous needle aspiration in combination with bactericidal antibiotics. Cerebellar granule neurons (CGN) cultured in the presence of serum and depolarizing potassium concentrations undergo apoptosis when switched to serum-free medium containing physiological potassium concentrations. NONHSAG013805 (down-regulated) and NONHSAG009271 (down-regulated) were common lncRNAs. The role of a sex-limited blood protein in egg formation by the Cecropia silkworm. Although Cdt1 is known to be essential for loading of Mcm onto the chromatin, its precise role in pre-RC formation and replication initiation is unknown. Trials on timing of thromboprophylaxis have been designed primarily to detect thrombotic events, and it has been difficult to interpret the magnitude of blood loss and bleeding events owing to lack of information for bleeding volume and underpowered bleeding end points.

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Functional electrical stimulation in external control of motor activity and movements of paralysed extremities. The influence of estrogen and anti-estrogen treatments on the bystander response was determined by individually irradiating a fraction of cells within the population with a precise number of helium-3 using a charged particle microbeam aricept dosage and administration . Identification of diverse dipeptidyl peptidase IV inhibitors via structure-based virtual screening. It appears from the pattern of drift that there was a drastic reduction of the standing crop of stream insects as a result of the spraying. The lowest risk index was in sheep and goat husbandry operations (0.35).

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Currently available data exploring flap salvage procedures are limited. Some showed undetectable ADA activity (less than or equal to 20 units/mg), whereas others maintained significant activity (50 to 500 U/mg). We report here the first mutation in a keratin gene (KRT1) that affects the variable tail domain (V2) and results in a profoundly different abnormality of the cytoskeletal architecture leading to a severe form of epidermal hyperkeratosis known as ichthyosis hystrix Curth-Macklin. Papain-triggered innate immune responses were dependent on both CD4 T cells and PAR2 and were strongly reduced in the absence of CCR4, the primary receptor for CCL17/CCL22. This was a prospective observational study of cases of OHPCA during sport or exertion in young patients presenting to an ED over a 5-year period. Molecular cloning, characterization and expression analysis of a catalase cDNA from hot pepper (Capsicum annuum L.). Measuring drinking patterns: the experience of the last half century.

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GPS tracking for a full day was feasible, although significant efforts are needed to impute missing data. These data show that EGF contributes to the differentiation and migration of myofibroblasts induced by TGF-beta1 through EGF-R activation and that it is an important modulator of wound healing and scar tissue formation. Spontaneous metastases from the UV-2237M-ADMR tumor commonly retained resistance to ADM. The metabolic rate of oxaprozin in rats is 3.5 and 7.2 times more rapid than in mice and dogs, respectively, and its blood level in rats is low. PUBLIC HEALTH VIEWS ITS SHARED RESPONSIBILITIES FOR SCHOOL HEALTH. Our study indicates that family function has an important influence on caregiver burden. Mortality and morbidity among the working population of anthophyllite asbestos miners in Finland.

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