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Benclamet (Glibenclamide)
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Benclamet

Benclamet belongs to a class of medicines called biguanides. It works by lowering glucose production in the liver, delaying the absorption of sugar from the intestines, and increasing the body's sensitivity to insulin.

Other names for this medication:
Afdiex, Aviglen, Benformin, Betrol, Bionil, Codica, Combidos, Daocon, Daonil, Diabetnil, Diabetrol, Diabnil, Duotrol, Dutrol, Euglucon, Eumet, Giclamide, Glibenclamide, Glibson, Glifil, Glinil, Glitrac, Glucomin, Gluconil, Glucored, Glucosil, Glucotrac, Glunil, Glutowin, Glybenclamide, Glybid, Glybonil, Glyboral, Glybovin, Glybovine, Glycurub, Iscept, Melitus, Metclam, Metica, Monomet, Pionorm, Secrin, Sugatrol, Sugnil, Sugnl, Sugronil, Sycored, Symet, Triglycomet

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Arava, Coreg, Prilosec, Lioresal, Altace, Fulvicin, Exelon, Nexium, Glysiss, Upderm, Faxiven, Veega, Zedep, Evomate, Astanol, Ulpanto, Megapress, Arrestadol,

Also known as: Glibenclamide

Description

Benclamet and metformin is a combination of two oral diabetes medicines that help control blood sugar levels.

Benclamet and metformin is used together with diet and exercise to improve blood sugar control in adults with type 2 diabetes. Benclamet and metformin is not for treating type 1 diabetes.

Dosage

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For type 2 diabetes:
    • For oral dosage form (tablets):
      • Adults—At first, 2.5 to 5 milligrams (mg) once a day taken with breakfast or the first main meal. Your doctor may adjust your dose if needed. However, the dose is usually not more than 20 mg per day.
      • Children—Use and dose must be determined by your doctor.

Overdose

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose can cause severe hypoglycemia or lactic acidosis.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Side effects

The most common side effects associated with Benclamet are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

You should not use Benclamet and metformin if you are allergic to Benclamet or metformin, or:

severe kidney disease; metabolic acidosis or diabetic ketoacidosis (call your doctor for treatment); or if you are also using bosentan (to treat pulmonary arterial hypertension).

If you need to have any type of x-ray or CT scan using a dye that is injected into your veins, you may need to temporarily stop taking Benclamet and metformin.

Tell your doctor if you have ever had:

kidney disease; an enzyme deficiency called glucose-6-phosphate dehydrogenase deficiency (G6PD); liver disease; or heart disease, heart attack, or stroke.

You may develop lactic acidosis, a dangerous build-up of lactic acid in your blood. This may be more likely if you have other medical conditions, a severe infection, chronic alcoholism, or if you are 65 or older. Ask your doctor about your risk.

Follow your doctor's instructions about using this medicine if you are pregnant or you become pregnant. Controlling diabetes is very important during pregnancy, and having high blood sugar may cause complications in both the mother and the baby. However, you may need to stop taking Benclamet and metformin for a short time just before your due date.

Metformin may stimulate ovulation in a premenopausal woman and may increase the risk of unintended pregnancy. Talk to your doctor about your risk.

You should not breastfeed while taking Benclamet and metformin.

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