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Benclamet (Glibenclamide)

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Benclamet belongs to a class of medicines called biguanides. It works by lowering glucose production in the liver, delaying the absorption of sugar from the intestines, and increasing the body's sensitivity to insulin.

Other names for this medication:
Afdiex, Aviglen, Benformin, Betrol, Bionil, Codica, Combidos, Daocon, Daonil, Diabetnil, Diabetrol, Diabnil, Duotrol, Dutrol, Euglucon, Eumet, Giclamide, Glibenclamide, Glibson, Glifil, Glinil, Glitrac, Glucomin, Gluconil, Glucored, Glucosil, Glucotrac, Glunil, Glutowin, Glybenclamide, Glybid, Glybonil, Glyboral, Glybovin, Glybovine, Glycurub, Iscept, Melitus, Metclam, Metica, Monomet, Pionorm, Secrin, Sugatrol, Sugnil, Sugnl, Sugronil, Sycored, Symet, Triglycomet

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Also known as: Glibenclamide


Benclamet and metformin is a combination of two oral diabetes medicines that help control blood sugar levels.

Benclamet and metformin is used together with diet and exercise to improve blood sugar control in adults with type 2 diabetes. Benclamet and metformin is not for treating type 1 diabetes.


The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For type 2 diabetes:
    • For oral dosage form (tablets):
      • Adults—At first, 2.5 to 5 milligrams (mg) once a day taken with breakfast or the first main meal. Your doctor may adjust your dose if needed. However, the dose is usually not more than 20 mg per day.
      • Children—Use and dose must be determined by your doctor.


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose can cause severe hypoglycemia or lactic acidosis.


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Side effects

The most common side effects associated with Benclamet are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


You should not use Benclamet and metformin if you are allergic to Benclamet or metformin, or:

severe kidney disease; metabolic acidosis or diabetic ketoacidosis (call your doctor for treatment); or if you are also using bosentan (to treat pulmonary arterial hypertension).

If you need to have any type of x-ray or CT scan using a dye that is injected into your veins, you may need to temporarily stop taking Benclamet and metformin.

Tell your doctor if you have ever had:

kidney disease; an enzyme deficiency called glucose-6-phosphate dehydrogenase deficiency (G6PD); liver disease; or heart disease, heart attack, or stroke.

You may develop lactic acidosis, a dangerous build-up of lactic acid in your blood. This may be more likely if you have other medical conditions, a severe infection, chronic alcoholism, or if you are 65 or older. Ask your doctor about your risk.

Follow your doctor's instructions about using this medicine if you are pregnant or you become pregnant. Controlling diabetes is very important during pregnancy, and having high blood sugar may cause complications in both the mother and the baby. However, you may need to stop taking Benclamet and metformin for a short time just before your due date.

Metformin may stimulate ovulation in a premenopausal woman and may increase the risk of unintended pregnancy. Talk to your doctor about your risk.

You should not breastfeed while taking Benclamet and metformin.

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Multidimensional characterization of an entangled photon-pair source via stimulated emission tomography. Medial plating had a higher prevalence of nonunion than lateral plating. Quantitative high-throughput screening (HTS) enables the identification of compounds with synthetic lethal activity not identified by single-dose HTS. Early outcomes after left subclavian artery revascularisation in association with thoracic endovascular aortic repair. Involving psychiatry trainees and nursing staff may be a sustainable approach in a setting with small number of consultants and limited funds to pay for professional actors. Enhancement of NK cell-mediated antibody-dependent lysis of recombinant gp120-coated CD4 cells by complement. Le Confluent private hospital in Nantes has opened a unit devoted to outpatient surgery. No study has compared the long-term outcomes between subtotal corpectomy and laminoplasty for multilevel cervical spondylotic myelopathy. It was observed that the development of food addiction in schizophrenic patients increased the risk of obesity and cardiovascular diseases, which were found to be at higher levels in these patients.

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Our small cohort showed significant mortality in patients with hematologic malignancy on immunosuppression, who had their renal mass treated with surgical excision or thermal ablation. Based on their medical records, subjects were classified by three independent judges as having been either severely or lightly injured. These results demonstrate that sodium-coupled transport processes in the kidney are sensitive to OXPHOS impairment. Cancer vaccines have the potential to induce curative anti-tumor immune responses and better adjuvants may improve vaccine efficacy. In addition, passaging of viruses collected from cells expressing the minigenome showed that the minigenome was being packaged and replicated in the presence of helper virus. We propose a simple and computationally inexpensive edge screening approach.

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Methylprednisolone therapy is effective in KD associated with nephrotic syndrome, and long-term administration of methylprednisolone at maintenance dose may be a way to prevent relapses of KD. Analysis of the waste selective collection at drop-off systems: Case study including the income level and the seasonal variation. Preliminary data indicate that the MATA-HD is a promising tool for measuring patient responses to music therapy interventions across psychological, physical, social, and communication domains of functioning in patients with advanced HD. The discovery of the FMR1 gene unraveled the cause of the most common form of heritable mental retardation and provided the prototype of dynamic mutations. Until the underlying mechanisms of protein and lipid metabolism are understood in both healthy and ill cats, dietary therapy remains supportive. Current approaches to drive their chondrogenic differentiation require extensive cell manipulation ex vivo and using exogenous growth factors. The observed THz vibrational modes are assigned to bending and torsional modes related to the intermolecular H-bond interactions with the help of potential energy distribution (PED) method. ORC and Cdc6p interact and determine the frequency of initiation of DNA replication in the genome.

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The importance of the posterior oblique ligament in repairs of acute tears of the medial ligaments in knees with and without an associated rupture of the anterior cruciate ligament. Mucocutaneous manifestations of lymphomas and leukemias in black Kenyan children. GnRH protein expression was validated by immunohistochemistry study. NAG-1/GDF15 accumulates in the nucleus and modulates transcriptional regulation of the Smad pathway. Previous studies have demonstrated the presence of small amounts of Vif in virus particles. sulfurreducens are dependent upon the metabolic byproducts of C. After sixty daily exposures over a period of three months with pupils dilated to 8 mm or greater, no anomalies were detectable in the retina.

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Although the active site of Gcn5L2 can accommodate propionyl-CoA and butyryl-CoA without major structural rearrangements, butyryl-CoA adopts a conformation incompatible with catalysis that obstructs the path of the incoming lysine residue and acts as a competitive inhibitor of Gcn5L2 versus acetyl-CoA. To evaluate the association between borderline ankle-brachial index (ABI) and clinical outcome in patients who underwent percutaneous coronary intervention (PCI). Acute exacerbations of COPD: reflections of an unfinished story. A national cross-sectional study for poliovirus seroprevalence in the Republic of Korea in 2012: implication for deficiency in immunity to polio among middle-aged people. Class I HDACs are similar to the nizoral shampoo in breastfeeding yeast transcriptional repressor yRPD3, while class II HDACs are related to yHDA1 and class III HDACs to ySIR2.

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A novel inbred rat model with inducible hypertension has been generated using a renin transgene under the transcriptional control of the cytochrome P450, Cyp1a1 promoter. Studies of populations of women with previous low transverse CS who underwent third-trimester evaluation of LUS thickness were selected. Heparin present in samples was removed by ECTEOLA (epichlorohydrin triethanolamine) cellulose resin adsorption, and coagulation factors were assayed by automated techniques. The latter mostly become manifest during childhood or adolescence. Results from the present study suggest that, in patients with hip osteoarthritis, genetic variants in OPRM1 and OPRD1 may contribute to the pain phenotype. Visual levaquin dose pack , quantitative SUV-based, and MTV-based assessment in interim PET/CT are valuable for early treatment response assessment in patients with PTCL, and the combined approach using the three parameters was more efficient in discriminating between patients with different survival outcomes compared with single-parameter assessment.

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Botulinum Toxin A Injections Into Pelvic Floor Muscles Under Electromyographic Guidance for Women With Refractory High-Tone Pelvic Floor Dysfunction: A 6-Month Prospective Pilot Study. More emphasis on TB infection control measures and regular staff screening may be needed. We performed transtemporal transcranial Doppler recordings from the P2-segments of both posterior cerebral arteries simultaneously during simple or complex visual stimulation. We conducted genetic association analysis in MHC region of each patient subgroup with shared control subjects. The purpose of this study was to quantify the prognostic impact of NLR on head and neck squamous cell carcinoma (HNSCC). Devising and circulating guideline proformas in conjunction with local education for referring doctors may help reduce the number of inappropriate ENT referrals. Akt is an important kinase in cell survival, and its activity is regulated by the upstream phosphoinositide 3-kinase (PI3K) and receptor tyrosine kinases (RTKs).

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