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Atipam (Lorazepam)
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Atipam

Atipam, an antianxiety agent, has the chemical formula, 7-chloro-5-(o-chlorophenyl)-1,3- dihydro-3-hydroxy-2H-1,4-benzodiazepin-2-one. It is a nearly white powder almost insoluble in water. Each Atipam tablet, to be taken orally, contains 0.5 mg, 1 mg, or 2 mg of Atipam. The inactive ingredients present are lactose monohydrate, magnesium stearate, microcrystalline cellulose, and polacrilin potassium.

Other names for this medication:
Almazine, Anxilor, Anxionil, Anxipose, Atipam, Biokalm, Biolar, Calmese, Dulozep, Larosh, Larpose, Lopam, Lopez, Loracalm, Lorakar, Loralite, Lorazam, Lorazepam, Lorazine, Loricon, Loripam, Lorivan, Lorpam, Lorvin, Lotweet, Nexlor, Norpose, Olraz, Trapex, Urpam, Zelor, Zepatrac, Zepnap

Similar Products:
Minocin, Inderal, Plavix, Xanax, Klonopin, Bystolic, Zudena, Otenol, Estogen, Apistorm, Dalcap, Lonipax, Atheroz, Nilconorm, Psycholanz, Metsar,

Also known as: Lorazepam

Description

Atipam belongs to a class of medications called benzodiazepines. These medications work by boosting the activity of gamma-aminobutyric acid (GABA) within your body.

GABA is a neurotransmitter that transmits messages between cells in different parts of your body. Increasing GABA in the body results in a tranquilizing effect that reduces feelings of stress and anxiety.

How long does it take to work?

Benzodiazepines such as Atipam are categorized based on how fast they work. Atipam is classified as having a rapid to intermediate onset (start) of action. It begins to work right away after it’s taken, but its peak effect occurs within 1 to 1.5 hours.

Dosage

Usual Adult Dose for Anxiety:

Initial dose: 2 to 3 mg orally per day, given 2 to 3 times per day Maintenance dose: 1 to 2 mg orally 2 to 3 times a day Comments: -The daily dosage may vary from 1 to 10 mg/day. -The dosage should be increased gradually when needed to help avoid adverse effects. -When higher dosage is indicated, the evening dose should be increased before the daytime doses. -Use of anxiolytic agents is typically not needed to treat anxiety/tension associated with the stress of everyday life. -Clinical studies have not evaluated this drug for efficacy in long-term treatment (e.g., greater than 4 months). Uses: -Management of anxiety disorders -Short-term relief of the symptoms of anxiety or anxiety associated with depressive symptoms

Usual Adult Dose for Insomnia:

2 to 4 mg orally once a day at bedtime Comments: -The dosage should be increased gradually when needed to help avoid adverse effects. -Clinical studies have not evaluated this drug for efficacy in long-term treatment (e.g., greater than 4 months). Use: Management of insomnia due to anxiety of transient situational stress

Usual Geriatric Dose for Anxiety:

Older or debilitated patients: -Initial dose: 1 to 2 mg orally per day, given in divided doses Comments: -The dosage should be increased gradually when needed to help avoid adverse effects. -The daily dosage may vary from 1 to 10 mg/day. -When higher dosage is indicated, the evening dose should be increased before the daytime doses. -Use of anxiolytic agents is typically not needed to treat anxiety/tension associated with the stress of everyday life. -Clinical studies have not evaluated this drug for efficacy in long-term treatment (e.g., greater than 4 months). Uses: -Management of anxiety disorders -Short-term relief of the symptoms of anxiety or anxiety associated with depressive symptoms

Detailed Atipam dosage information

Overdose

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of lorazepam can be fatal if you take it with alcohol, opioid medicine, or other drugs that cause drowsiness or slow your breathing.

Overdose symptoms may include extreme drowsiness, confusion, slurred speech, feeling restless, muscle weakness, loss of balance or coordination, feeling light-headed, slow heartbeats, weak or shallow breathing, or coma.

Storage

Store Ativan at room temperature away from moisture, heat, and light.

Keep track of the amount of medicine used from each new bottle. Atipam is a drug of abuse and you should be aware if anyone is using your medicine improperly or without a prescription.

Side effects

The most common side effects associated with Atipam are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Atipam should be avoided in people with:

Sleep apnea – Sleep apnea may be worsened by Atipam's central nervous system depressant effects. It may further reduce the patient's ability to protect his or her airway during sleep.

Myasthenia gravis – This condition is characterized by muscle weakness, so a muscle relaxant such as Atipam may exacerbate symptoms.

Pregnancy and breast feeding – Atipam belongs to the Food and Drug Administration (FDA) pregnancy category D, which means it is likely to cause harm to the developing baby, if taken during the first trimester of pregnancy. Evidence is inconclusive whether Atipam, if taken early in pregnancy, results in reduced intelligence, neurodevelopmental problems, physical malformations in cardiac or facial structure, or other malformations in some newborns. Atipam given to pregnant women antenatally may cause floppy infant syndrome in the neonate, or respiratory depression necessitating ventilation. Regular Atipam use during late pregnancy (the third trimester), carries a definite risk of benzodiazepine withdrawal syndrome in the neonate. Neonatal benzodiazepine withdrawal may include hypotonia, reluctance to suck, apneic spells, cyanosis, and impaired metabolic responses to cold stress. Symptoms of floppy infant syndrome and the neonatal benzodiazepine withdrawal syndrome have been reported to persist from hours to months after birth. Atipam may also inhibit fetal liver bilirubin glucuronidation, leading to neonatal jaundice. Atipam is present in breast milk, so caution must be exercised about breast feeding.

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Clinical significance: history, application, and current practice. Occasionally, in the presence of TTX (1 X 10(-7) M) the cardiac arrest occurred, and then very irregular contractions appeared. This article describes the need for and the practicality and utility of longitudinal, multisector, and multilevel administrative data to address key issues in child maltreatment prevention and intervention. Molecular and Supermolecular Structure of Commercial Pyrodextrins. They suggested that the relative proportion of the three different conformations of biotin in the solution was responsible for different activities of the two amide protons of biotin. The application of standard medium supplemented with 2 m M taurine resulted in a significant increase of the b-wave amplitude compared to standard medium alone.

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Acute and subacute inflammation of the optic nerve and its sheath: clinical features in Chinese patients. The lactic acid and ethanol concentration profiles were affected positively by keeping the pH constant at a minimum of 4.0 as well as the l- and d-lactic acid ratio profile, a potential biological marker for sourdough stability and maturity. Isolation and antimicrobial susceptibility testing of fecal strains of the archaeon Methanobrevibacter smithii. It is now evident that the role of CIN in tumor initiation and growth is more complex than previously thought. The concept of Gemeinschaft in health planning and management: a Japanese perspective. The development of next-generation sequencing (NGS) technologies is transforming the practice of medical genetics and revolutionizing the approach to heterogeneous hereditary conditions, including skeletal muscle disorders. These results suggest that the activity of pyruvate dehydrogenase complex is intimately related to the onset of diabetes. Drug interactions with colesevelam hydrochloride, a novel, potent lipid-lowering agent.

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Prolonged red cell survival following in vitro treatment with potassium cyanate. We present the first general method to locate and visualize chaotic saddles in higher dimensions. Influence of Crassostrea gigas (Thunberg) sexual maturation stage and ploidy on uptake of paralytic phycotoxins. The aim of this study is to determine the relationship of Foxp3 expression with clinicopathological parameters and prognosis in oral squamous cell carcinoma (OSCC). Blessings: the influence of a spirituality-based intervention on psychospiritual outcomes in a cardiac population. Single photon emission computed tomography was used to evaluate the total functioning liver mass and the regeneration process after partial hepatectomy. This commonality further strengthens the possibility that septal neurons are important to central modulation of body temperature.

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Our data provide the first demonstration of RhoB phosphorylation and indicate that this post-translational maturation would be a novel critical mechanism to control the RhoB functions. By comparing different examples of wound-induced tissue regeneration in the model plant Arabidopsis thaliana, a number of key regulators of developmental plasticity of plant cells have been identified. Histologically, all of the rats in the TD group exhibited epidermal thinning from 12 weeks after surgery. We exhaustively classify linear and quadratic three-, six-, and eight-band crossings stabilized by space group symmetries in solid-state systems with spin-orbit coupling and time-reversal symmetry. The experiments also showed a low soluble ammonia nitrogen generation that was rapidly depleted, confirming the existence of ammonification. Microelectrophysiological analysis of the cardiac effect of prostaglandin E2.

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Prevention will entail detecting infants at risk before the full syndrome is present and implementing treatments designed to alter the course of early behavioral and brain development. Relationship between visitation policy in a pediatric intensive unit and parental anxiety. In microbial reaction systems, there are a number of linear relations among net conversion rates. Clindamycin and gentamicin are frequently prescribed by obstetricians and gynecologists (OB-GYN) for various pelvic infections in women. In our experience, HBS allowed the identification and the sparing of more functioning liver areas, thus potentially reducing the risk of radiation-induced liver toxicity. Two clones were used: clone CTLL-A2 which recognizes H-2Dd determinants and clone CTLL-R5 which recognizes a unique cell surface antigen of BALB/c leukemia RL male 1.

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There have been limited efforts in this arena within the field of urology, as cost, logistical and ethical issues represent significant deterrents to biobanking. Magnetic resonance imaging of liver metastases: experimental comparison of anionic and conventional superparamagnetic iron oxide particles with a hepatobiliary contrast medium during dynamic and uptake phases. Our results suggest that CR with or without RT is effective in improving metabolic profile, whereas RT is effective in improving physical capacity. If proven to be effective, this novel approach to malaria control would be a valuable addition to the existing strategies of long-lasting insecticide-treated nets and case management. Microbubbles were intravenously injected before focused ultrasound exposure. Gray matter-changes and correlates of disease severity in schizophrenia: a statistical parametric mapping study. Evaluation of the neuroprotective effects of sodium channel blockers after spinal cord injury: improved behavioral and neuroanatomical recovery with riluzole. In this article the method is generalized by allowing this variable to have any distribution. The effect of hyper- and hypotensive drugs on experimental microembolic lesions of the brain in animals.

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The contribution of savannas to global carbon storage is poorly understood, in part due to lack of knowledge of the amount of belowground biomass. The survey used standardized, case-based scenarios involving pharmacologic interventions known to improve health outcomes. The combined detection of serum HE4 and CA(125) is helpful to the diagnosis of endometrial carcinoma. Nutmeg liver and ascites resulting from a membranous web obstruction at the hepatic origin of the inferior vena cava. Outcome of Burch retropubic urethropexy and the effect of concomitant abdominal hysterectomy: a prospective long-term follow-up study. Evaluation of final visual acuity, complications, differences in patients receiving an intraocular lens at the primary cataract surgery, and differences in final visual acuity regarding the usage of a phacofragmatome and analysis of pars plana vitrectomy-related complications. Carbon dioxide during and after the apnoea test--an illustration of the Haldane effect. A decrease in bone mineral density may lead to an increased susceptibility to bone fractures. Consistent with perceptual load theory, increasing visual task load suppressed SSEPs to the ignored visual checkerboards. He underwent a biopsy for a tumor of the left frontal lobe 4 months prior to presentation, and the tumor had been diagnosed as primary central nerve system B-cell type lymphoma.

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The starting point for the present investigations was the finding that increasing influent concentrations from 10 to 380 mmol/L glucose decreased the attainable growth rate of an acidogenic population in continuous culture from 0.52 to 0.05 h(-1) To account for this phenomenon, a new kinetic model is developed that combines substrate and product inhibition. This article describes a combination of analog techniques, including bone sounding and periapical radiographs used to study the available bone volume. Then, the Cy5-attached protein was denatured with SDS and was further stained, during electrophoresis, with Agilent fluorescent dye, which was noncovalently attached to hydrophobic regions of the SDS-protein complexes. Glycoprotein synthesis and secretion by mucosal biopsies of rabbit colon and human rectum. Serum hsCRP improved with lifestyle modification and metformin therapy for 3 months in overweight subjects from India with PCOS, along with serum total cholesterol, triglycerides, and HDL-C. Macroporous crosslinked poly(p-vinylphenyltrimethylamine) (PVPTA) and its oxidized adsorbent (OPVPTA) were synthesized and their adsorption behaviors for phenol were comparatively studied in hexane as well as in aqueous solution. Additionally, mtCx43, p-mtCx43, AKT, and p-AKT levels were determined. Although p53 tumor suppressor is required for TGF-beta-induced p21 WAF1 expression and cell growth inhibition, its role in TGF-beta-induced apoptosis remains unclear.

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In order to evaluate the mechanism of cytotoxicity of these extracts, they were assessed for their ability to scavenge hydroxyl radicals in plasmid nicking assay with pBR322. Improving the evidence base will require greater investment in evaluation and addressing the marginalization of people with intellectual disabilities in CBR. Botryodiplodia theobromae and Aspergillus aculeatus were inoculated in carboxymethylcellulose (CMC) medium and on filter papers. Under genetic mechanisms where the risk allele of the tested locus has an effect exclusively in subjects with the endophenotype, the risk allele frequency differences between affected and unaffected subjects are much greater in the subset of subjects with an endophenotype impairment than in those without such an impairment, and power gains are obtained when testing the association under a joint disease-endophenotype model, both with two-locus or single-locus tests. This week Alison Woodland discusses sexually transmitted diseases. Self-reported adherence was determined using the visual analog scale (VAS) and AIDS Clinical Trial Group (ACTG) questionnaire 4-day recall. The model was verified using trauma services utilization data from the British Columbia Trauma Registry. Size of the SDN-POA and reproductive ability was comparable to those in controls. Studies on the cultivation of endamoeba histolytica with Trypanosoma cruzi. Codeine and aspirin analgesia in postpartum uterine cramps: qualitative aspects of quantitative assessments.

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Studies in vivo and in vitro of the transfer of rat IgG and rat albumen across the intestinal walls of young rats. The efficiency of peritoneal dialysis by the use of hyperosmolar dialyzing fluid (680 mOsm/1) was studied in 7 patients with chronic renal failure. 8-OH-DPAT is a 5-HT( ultram renal dosing 1A/7) receptor agonist that enhances behavioral recovery after traumatic brain injury (TBI). These sound-symbolic relationships have been suggested to result in easier language acquisition, but previous studies have explicitly tested effects of sound symbolism on learning category distinctions but not on word learning. The diffusion tensor model, which is widely used for this purpose, has been shown to be inadequate in crossing fibre regions. During premetamorphosis the response increased, while during prometamorphosis , particularly at stages 57-58, there was a marked reduction. With the development of biological technology, many genetically engineered microorganisms (GEMs) for special purposes have been constructed and developed, but their practical applications in the field are still limited because GEMs may cause new environmental contaminations.

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Study guides improves self-learning skills in clinical endocrinology. A mechanistic stochastic framework for regulating bacterial cell division. A disturbance in the ability to switch attention during the out-of-phase task may also be involved. I introduce a novel and general method to conditionally perturb anatomically defined neurons in intact Drosophila. Changes at the organisational and personnel levels can be made to better support same-sex mothers and co-mothers. The changes in expression of LECT2 mRNA were investigated after concanavalin A (Con A)-induced hepatic injury in mice. Long-lived dipolar molecules and Feshbach molecules in a 3D optical lattice.

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