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Assepium (Trimethoprim)

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Assepium (sulfamethoxazole / trimethoprim) is absorbed by the body and begins to kill bacteria within 1 to 4 hours after taking your dose. For more common problems like urinary tract infections and ear infections, most people will start to feel relief after a few days.

Other names for this medication:
Bactricid, Bactricida, Bactrizol, Berlocid, Biotrim, Biseptrin, Bitrim, Cosat, Cotrimol, Cotrimox, Cotrimoxazol, Cotrimstada, Danferane, Deprim, Droxol, Erphatrim, Fisat, Gentrim, Globaxol, Groprim, Ifitrim, Infectrim, Letus, Neoset, Primotren, Sepmax, Septra, Septran, Servitrim, Suftrex, Sulfamethoxazol, Sulphatrim, Suprimass, Trimethazol, Trimethoprim, Trimexazol, Trimoks, Trimosazol, Trimosul, Vanasulf

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Also known as: Trimethoprim


This medication is used to treat a wide variety of bacterial infections. It is also used to treat a certain type of pneumonia (pneumocystis pneumonia) in patients with a weakened immune system. This medication is a combination of 2 antibiotics: sulfamethoxazole and trimethoprim. It works by stopping the growth of bacteria and the pneumocystis fungus.


This section provides information on the proper use of a number of products that contain sulfamethoxazole and trimethoprim. It may not be specific to Assepium DS. Please read with care.

Take this medicine exactly as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. To do so may increase the chance of side effects.

Sulfamethoxazole and trimethoprim combination is best taken with a full glass (8 ounces) of water. Several additional glasses of water should be taken every day, unless otherwise directed by your doctor. Drinking extra water will help to prevent some unwanted effects (eg, crystals in the urine). .

For patients taking the oral liquid, use a specially marked measuring spoon or other device to measure each dose accurately. The average household teaspoon may not hold the right amount of liquid.

To help clear up your infection completely, keep using this medicine for the full time of treatment, even if you begin to feel better after a few days. If you stop taking this medicine too soon, your symptoms may return.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For oral dosage forms (liquid or tablets): For treatment of bacterial infections: Adults—1 tablet (DS tablet) of 800 milligrams (mg) of sulfamethoxazole and 160 mg of trimethoprim, 2 tablets of 400 mg of sulfamethoxazole and 80 mg of trimethoprim, or 4 teaspoonfuls or 20 milliliters (mL) of oral liquid every 12 hours for 10 to 14 days. Your doctor may adjust this dose if needed. Children 2 months of age and older—Dose is based on body weight and must be determined by your doctor. The usual dose is 40 milligrams (mg) per kilogram of body weight of sulfamethoxazole and 8 milligrams (mg) per kilogram of body weight of trimethoprim, given in two divided doses every 12 hours for 10 days. Weighing 40 kilograms (kg)—4 teaspoonfuls (20 mL) of oral liquid or 2 tablets (or 1 DS tablet) 2 times a day for 10 days. Weighing 30 kg—3 teaspoonfuls (15 mL) of oral liquid or 1 ½ tablet 2 times a day for 10 days. Weighing 20 kg—2 teaspoonfuls (10 mL) of oral liquid or 1 tablet 2 times a day for 10 days. Weighing 10 kg—1 teaspoonful (5 mL) of oral liquid 2 times a day for 10 days. Children younger than 2 months of age—Use is not recommended. For treatment of bronchitis: Adults—1 tablet (DS tablet) of 800 milligrams (mg) of sulfamethoxazole and 160 mg of trimethoprim, 2 tablets of 400 mg of sulfamethoxazole and 80 mg of trimethoprim, or 4 teaspoonfuls or 20 milliliters (mL) of oral liquid every 12 hours for 14 days. Children 2 months of age and older—Use and dose must be determined by your doctor. Children younger than 2 months of age—Use is not recommended. For treatment of Pneumocystis jiroveci pneumonia or Pneumocystis carinii pneumonia (PCP): Adults and children 2 months of age and older—Dose is based on body weight and must be determined by your doctor. The usual dose is 75 to 100 milligrams (mg) per kilogram of body weight of sulfamethoxazole and 15 to 20 milligrams (mg) per kilogram of body weight of trimethoprim each day, given in equally divided doses every 6 hours for 14 to 21 days. Weighing 80 kilograms (kg)—10 teaspoonfuls (50 milliliters (mL)) or 5 tablets (or 2 ½ DS tablets) 4 times a day for 14 to 21 days. Weighing 64 kg—8 teaspoonfuls (40 mL) or 4 tablets (or 2 DS tablets) 4 times a day for 14 to 21 days. Weighing 48 kg—6 teaspoonfuls (30 mL) or 3 tablets (or 1 ½ DS tablets) 4 times a day for 14 to 21 days. Weighing 40 kg—5 teaspoonfuls (25 mL) or 2 ½ tablets 4 times a day for 14 to 21 days. Weighing 32 kg—4 teaspoonfuls (20 mL) or 2 tablets (or 1 DS tablet) 4 times a day for 14 to 21 days. Weighing 24 kg—3 teaspoonfuls (15 mL) or 1 ½ tablets 4 times a day for 14 to 21 days. Weighing 16 kg—2 teaspoonfuls (10 mL) or 1 tablet 4 times a day for 14 to 21 days. Weighing 8 kg—1 teaspoonful (5 mL) 4 times a day for 14 to 21 days. Children younger than 2 months of age—Use is not recommended. For prevention of Pneumocystis jiroveci pneumonia or Pneumocystis carinii pneumonia (PCP): Adults—800 milligrams (mg) of sulfamethoxazole and 160 mg of trimethoprim once a day. Children 2 months of age and older—Dose is based on body size and must be determined by your doctor. The usual dose is 750 mg of sulfamethoxazole and 150 mg of trimethoprim per square meter (m[2]) of body surface each day. This is given in equally divided doses two times a day for 3 days a week on consecutive days (eg, Monday, Tuesday, Wednesday). However, the dose is usually not more than 1600 mg of sulfamethoxazole and 320 mg of trimethoprim per day. Children younger than 2 months of age—Use is not recommended. For treatment of traveler's diarrhea: Adults—1 tablet (DS tablet) of 800 milligrams (mg) of sulfamethoxazole and 160 mg of trimethoprim, 2 tablets of 400 mg of sulfamethoxazole and 80 mg of trimethoprim, or 4 teaspoonfuls or 20 milliliters (mL) of oral liquid every 12 hours for 5 days. Children 2 months of age and older—Use and dose must be determined by your doctor. Children younger than 2 months of age—Use is not recommended.


Often, no treatment is needed for an antibiotic overdose. Usually, you'll need to watch for stomach upset and possibly diarrhea. In those cases, you should give extra fluids.


Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets. Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.

Side effects

The most common side effects associated with Assepium are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of sulfamethoxazole and trimethoprim combination in the elderly. However, elderly patients are more likely to have a folate deficiency, age-related kidney or liver problems, and may be more likely to experience unwanted side effects (eg, severe skin rash, increased potassium in the body, or problems with blood clotting or the immune system). There may be an adjustment in the dose for elderly patients receiving sulfamethoxazole and trimethoprim combination.

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Renal function after complete bilateral ureteral obstruction following colporrhaphy. The authors present a case of tuberculous aortitis with mycotic aneurysms that presented with uncontrolled hypertension and occlusion of the right renal artery that underwent successful surgical repair. Patients, treating physicians, pharmaceutical companies, and regulatory authorities have differing needs, which may have important implications in planning and conducting RCTs. All SG-HCS demonstrated greater biomechanical characteristics than the first generation Herbert-Whipple screw. STABILITY OF THE DOSE-RESPONSE RELATIONSHIP FOR THE ASSAY OF LUTEINIZING HORMONE ACTIVITY. We evaluated and compared the efficacy of the World Health Organization (WHO) oral rehydration solution (ORS) and 2 different formulations of reduced osmolarity ORSs in infants with persistent diarrhea. The genetic analysis of female preferences has been seen as a particularly challenging empirical endeavor because of difficulties in generating suitable preference metrics in experiments large enough to adequately characterize variation.

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Efficient genome editing in filamentous fungus Trichoderma reesei using the CRISPR/Cas9 system. Similarly, although rates of unauthorized absence and desertion increased significantly from pre- to posttreatment for alcohol abusers, the increases were proportionately less than those experienced by either control group. A total of 76 patients with schizophrenia or schizoaffective disorder and a sample of 30 healthy participants were tested with the Reading the Mind in the Eyes test (Eyes-test). Recent strategies in the development of new human cytomegalovirus inhibitors. Bayesian statistical inference offers a principled and comprehensive approach for relating psychological models to data. This appearance was due to early postoperative edema or to transient deformity of the pliable residual hemilarynx during deglutition, as shown by videotaped fluoroscopy. At each step to the way, a water pathway is present and is invoked in the proposed model as the carrier of the message via proton hopping. Early Treatment of Acute Complex Regional Pain Syndrome after Fracture or Injury with Prednisone: Why Is There a Failure to Treat?. Most of the cases were confused clinically with sebaceous cysts.

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In vitro study of hydroxyapatite-based photocurable polymer composites prepared by laser stereolithography and supercritical fluid extraction. Routine high-precision analysis of triple water-isotope ratios using cavity ring-down spectroscopy. Changes in the tuberculosis situation among Finnish Lapps 1951--1968. Ureteral stenosis should be considered as a differential diagnosis for hydronephrosis in dogs, particularly when urinary tract calculi or neoplasia is not present. However, by injecting single pairs of related or unrelated sensory and motor cells with HRP, we found that related pairs formed anatomical contacts with each other more frequently than unrelated sensory-motor pairs did. Comparison of two detail screen-film systems using a rheumatoid erosion model. On the effect of cardiac glycosides on the tonus of the lymphatic vessels.

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The aim of this study was to develop indicators of conformance in clinical practice with guidelines for care in schizophrenia. To investigate the influence of different clinical and magnetic resonance imaging characteristics on cortical perfusion. A pharmacological analysis of the depression evoked by 5-HT suggested an action partly mediated by 5-HT(1A) receptor activation, since antagonism of the 5-HT(1A) receptor with NAN-190 or WAY-100635 partly reversed 5-HT-evoked depression. Blood gas analysis of forearm veins--at rest and after exercise of forearm muscles and laser Doppler flowmetry of skin on coreg dose the back of the palm--use in evaluation of microcirculation in diabetes type 2. Viscoelastic measurement of clot formation: a new test of platelet function. Our first suggestion is to use a t-reference distribution with k-1 degrees of freedom rather than a standard normal distribution for the usual random effects test statistic.

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Proteins in human serum are increasingly being studied for their roles in a wide variety of biochemical interactions. The quality of this measure was shown to depend on the quality of current health facility financial accounting data, on the quality of forecasts of interest rates and future cashflow, and on the appropriateness of the criterion debt service coverage ratio. This study reveals the critical role of recipient multi-sensory integration areas in network reorganization and cross-modal plasticity in blind individuals. EXPERIENCE IN CONTROL OF FUNGUS DISEASES IN THE ALKEEV DISTRICT OF THE TATAR AUTONOMOUS SSR. Cortisol Stress Response Variability in Early Adolescence: Attachment, Affect and Sex. Effect on blood sugar of normal subjects and diabetics of various types. Recent demonstrations of clinically relevant analyte detection by MRR sensor arrays have moved this technology closer to commercialization. There is a need for further exploration of its use in patients with depression. Recovery operations following an aircraft accident involving radioactive cargo. Skp2 interacts with NBS1 and triggers K63-linked ubiquitination of NBS1 upon ambien dosage 10 mg DSBs, which is critical for the interaction of NBS1 with ATM, thereby facilitating ATM recruitment to the DNA foci for activation.

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We report three patients with partial atrioventricular septal defect who presented in the neonatal period with excessive left to right shunting and progressive pulmonary hypertension. We investigated the effects of KRG and its primary ginsenoside on EtOH-induced injury to TIB-73 cells and evaluated MAPKs signals as a possible mechanism of action. A broadly tunable terahertz Solc-type birefringence filter is demonstrated. On the utility of isotopic fine structure mass spectrometry in protein identification. Here, we investigated whether this difference could be due to differences in the degree of dopamine receptor activation in the NAc. Missense mutation of the interleukin-12 receptor beta1 chain-encoding gene is associated with impaired immunity against Mycobacterium avium complex infection. Impact of a Web-Portal Intervention on Community ADHD Care and Outcomes. Differentiation into hair cells type I and type II was clearly evident at this stage. Multiple inhibitory activities in the dopamine family were selected in order to derive its molecular selectivity.

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Dietary patterns and their association with food and nutrient intake in the European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam study. Based on the available data, it might be impossible to advise an optimal or best-evidence strategy of lung preservation during CPB. The number of survivors depends on the metronidazole concentration, light intensity, preinduction of the hydrogenase, and the presence or absence of O2. The extent of these complications (many of which are due to poor user technique), increasing criticism of the routine use of these catheters, and the growing availability of less invasive, lower-risk technologies that can supply some of the same clinical information all argue persuasively for hospitals to formulate or what type of drug is protonix reexamine guidelines for appropriate use of invasive hemodynamic monitoring. The aim of this study was to report the prevalence of anaemia in patients with cancer located in different anatomical segments of the colon and rectum and to assess possible risk factors for this anaemia. Staphylococcal spondylitis--cause of a recurrent fever for 24 years.

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Duplex ultrasound, CT angiography and digital subtractional angiography revealed occlusion of left common carotid artery (CCA) and moderate to severe stenosis of right internal carotid artery (ICA). National Health Service support is found for the presence of supplier-inducement. permeable) US-Mexico border reduced the estimated proximity to Mexico City among Americans who felt threatened by Mexican immigration. Quality of stimuli and prefrontal lesions effects on reversal learning in go-no go avoidance reflex differentiation in cats. RESULTS OF ANTERIOR SPINE FUSION BY EXTRAPERITONEAL APPROACH FOR SPONDYLOLYSIS AND SPONDYLOLISTHESIS. The presence of currently untreated systemic complications of RA, such as dyslipidemia and anemia, provides interesting opportunities to include these in the preclinical evaluation of new therapies. It is concluded that this sign is useful in diabetics with impotence, the presence of intact testicular sensation indicating that the impotence is unlikely to be due to autonomic neuropathy. Culturing embryonic nasal explants for developmental and physiological study. PHYSICAL THERAPY, BALNEOLOGY, DISEASES OF THE GASTROINTESTINAL SYSTEM. 26S rRNA genes and ITS sequences, from cultured fungal isolates revealed different species of Cryptococcus, Rhodotorula, Debaryomyces, Trametes, and Penicillium, which are genera newly associated with Dactylopius.

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Histological examination revealed a neoplasm composed of invave ductal carcinoma with a direct transition to chondrosarcomatous areas. Trait v state dependency of the phenomenon was analyzed, and several technological limitations were considered. Cortical representation of animate and inanimate objects in complex natural scenes. The presence of high levels of microbial contamination may be a health problem for dentists and patients, especially those who are immunocompromised. The use of topical antifungal agents in the treatment of onychomycosis is of great value in clinical practice as there are different limitations regarding the use of systemic treatment. aceclofenac 100 mg tablet A retrospective study was conducted on 60 patients (53 females, seven males with a mean age of 68 years and 5 months) who underwent a total knee replacement using a mobile bearing. APOBEC3A, APOBEC3B, and APOBEC3H haplotype 2 restrict human T-lymphotropic virus type 1.

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No blood specimen from control patients had the Maspin transcript, while only one was positive for Mammaglobin. parasitica life cycle into nine stages and compared its progression through these stages in the defense-compromised hosts and price of enalapril tablets in wild-type plants. Pathological examinations were performed to confirm tissue necrosis and to determine whether there were unaffected tissues within the exposed volume. This study showed no positive effect of PRP on bone density in CT evaluation when used in sinus floor augmentation. A challenge for the future: coding diagnostic criteria for mental disorders. Although both AAF treatment and bile duct ligation results in proliferation of biliary epithelial cells, the mechanism(s) responsible for the proliferation of the biliary epithelium seems to differ in the two models. CONSIDERATIONS AND ANATOMO-CLINICAL OBSERVATIONS ON SEROUS CARCINOMA OF THE OVARY.

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