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Aspitrate (Isosorbide)

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Aspitrate is an inexpensive drug used to prevent chest pain caused by angina. It is more popular than comparable drugs. Aspitrate is only available as a generic drug; all brands have been discontinued.

Other names for this medication:
Aspitrate, Dilatrate, Ecosmin, Ismorin, Ismotic, Isoditrate, Isoloprin, Isordil, Isosorbide, Monit, Monoket, Monosprin, Nitren, Nitrofix, Nitroprin, Solosprin, Vasoprin

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Lunesta, Viramune, Neoral, Antivert, Imdur, Cordarone, Moduretic, Adalat, Pamelor, Tribet, Limet, Ebivol, Fexoquin, Doxazosin, Recarb,

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Also known as: Isosorbide


Aspitrate (isosorbide mononitrate) is a nitrate that dilates (widens) blood vessels, making it easier for blood to flow through them and easier for the heart to pump.

Aspitrate is an extended release tablet used to prevent angina attacks (chest pain).

Aspitrate will not treat an angina attack that has already begun.


This section provides information on the proper use of a number of products that contain isosorbide mononitrate. It may not be specific to Aspitrate ER. Please read with care.

Take this medicine exactly as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered.

This form of nitrate is used to reduce the number of angina attacks over a long time. It will not relieve an attack that has already started because it works too slowly. The extended-release form gradually releases medicine to provide its effect for 8 to 10 hours. Check with your doctor if you also need a fast-acting medicine to relieve the pain of an angina attack.

You should take this medicine first thing in the morning and follow the same schedule each day. This medicine works best if you have a "drug-free" period of time every day when you do not take it. Your doctor will schedule your doses during the day to allow for a drug-free time. Follow the schedule of dosing carefully so the medicine will work properly.

Swallow the extended-release tablet whole with a half glass of water. Do not split, crush, or chew it.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For prevention of angina: For oral dosage form (extended-release tablets): Adults—At first, 30 or 60 milligrams (mg) once a day. Take the dose in the morning right after you wake up. Your doctor may increase your dose as needed. Children—Use and dose must be determined by your doctor. For oral dosage form (tablets): Adults—20 milligrams (mg) two times a day. Take the first dose in the morning right after you wake up, and the second dose 7 hours later. Children—Use and dose must be determined by your doctor.


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of isosorbide mononitrate can be fatal.

Overdose symptoms may include a severe throbbing headache, fever, confusion, severe dizziness, fast or pounding heartbeats, vision problems, nausea, vomiting, stomach pain, bloody diarrhea, trouble breathing, sweating, cold or clammy skin, fainting, and seizure (convulsions).


Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture and heat. Keep container tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

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The most common side effects associated with Aspitrate are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Do not take Generic Aspitrate if you are allergic to Generic Aspitrate components. Do not take Generic Aspitrate if you're pregnant or you plan to have a baby. Do not use potassium supplements or salt substitutes. Be careful using Generic Aspitrate if you take dihydroergotamine (D.H.E. 45); or any other heart medicines, especially those used to treat high blood pressure or irregular heartbeats. Be careful using Generic Aspitrate if you suffer from or have a history of congestive heart failure, have low blood pressure; a stroke, a transient ischemic attack (TIA, or mini-stroke), have anemia; have an allergy to nitrates; have closed-angle glaucoma; migraines, kidney disease; liver disease, heart attack, a serious head injury. If you want to achieve most effective results without any side effects it is better to avoid alcohol. Be very careful when you are driving machine. Do not stop taking Generic Aspitrate suddenly.

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The active GTP-bound form of Rab35 accumulates on bacteria-containing endosomes, and Rab35 directly binds and recruits NDP52 to internalized bacteria. Fibril crystal growth in diblock copolymer solutions studied by dynamic Monte Carlo simulations. We assess to what extent associations between obesity and sexuality are explained by physical, psychological, and sexual health, and by relationship quality. The optical properties of the target compound nicely complement those of the solar cell and sensitization helps to avoid Staebler-Wronski photo-degradation. Concluding remarks are provided on the future of research in community psychology. MS is frequent in our population diagnosed with primary hyperparathyroidism, adverse cardiovascular parameters are common and significant differences in calcium metabolism compared to the non-MS group are present. Allogeneic stem cell transplantation (alloSCT) is the preferred option of postremission therapy for high-risk patients suffering from acute myeloid leukemia (AML).

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Twenty nine year old female of white British ethnic origin, presenting to a primary care clinic with a three year history of intermittent left distal medial thigh pain. decorticatum and Dictyota dichotoma) were found to enhance macroalgal uptake. Tetrandrine reverses drug resistance in isoniazid and ethambutol dual drug-resistant Mycobacterium tuberculosis clinical isolates. Tissue conditions of healing and spontaneously perforated bronchus stumps following pneumonectomy. Our findings demonstrate that spartin acts as an adaptor protein that activates and recruits AIP4 E3 ubiquitin ligase to lipid droplets and by this means regulates the level of ubiquitination of adipophilin and potentially other lipid-associated proteins. A different genetic background is postulated for alcoholics with early onset and with antisocial personality disorder (type 2 alcoholics) compared with those with late onset and without antisocial personality disorder (type 1 alcoholics). SHH stimulation did not affect cell growth but suppressed colony formation, increased the levels of cleaved NOTCH1 fragment characteristic for NOTCH1 activation, and upregulated mRNA expression of HES1, while decreasing that of MYC in Jurkat cells. This finding may reflect different coping mechanisms between black versus white Hispanics and related blood pressure levels during daytime exposures to discrimination.

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the civil war also meant that 36 per cent of households were left headed by widows. This highlights the importance of life history and demographic structure in studying evolutionary dynamics. Systematic review: patient-reported outcome measures in coeliac disease for regulatory submissions. Cognitive behavioural therapy and mindfulness for stress and burnout: a waiting list controlled pilot study comparing treatments for parents of children with chronic conditions. Because the human Usher Syndrome 1D-associated mutation, CDH23 R3175H, maps to the CBM, we created a matched mutation in mouse CDH23-C at R55H. In summary, our data together indicate that in prostate epithelia, cPAcP interacts with and dephosphorylates ErbB-2 primarily at Tyr(1221/2) and hence blocks downstream signaling, leading to reduced cell growth. We propose an enhanced method to improve selection of the best disease targets for a multilayer biomedical network that integrates PPI data annotated with stable knowledge from OMIM diseases and GO biological processes. Pharmacokinetic profile after multiple deltoid or gluteal intramuscular injections of paliperidone palmitate in patients with schizophrenia.

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Supporting health insurance expansion: do electronic health records have valid insurance verification and enrollment data?. Five broad absorption peaks were observed at 0.69, 1.08, 1.27, 1.47 and 1.64 THz respectively. bahamensis as indicators of susceptibility to pine tortoise scale and as predictors of environmental stresses. Prevention strategies were categorized as environmental, behavioral, or administrative. Stools from 2001 travelers and 215 nontraveling household members, collected before and immediately post-travel as well as 1, 3, 6 and 12 months upon return, were screened for CPE. Metastasis Risk Reduction Related with Beta-Blocker Treatment in Mexican Women with Breast Cancer. To culture adherent cells in suspension, such as skin-derived precursor Schwann cells (SKP-SCs), microcarriers need to be used. Inflammation is known to be strongly associated with knee pain in osteoarthritis. Co-expression of pregnane X receptor and ATP-binding cassette sub-family B member 1 in peripheral blood: A prospective indicator for drug resistance prediction in non-small cell lung cancer. Delivery and Measurement of High-Value Care in Standardized Patient Encounters.

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Results suggested that moderate and high use of sexting could be a risk factor for some problematic behaviors such as dating violence, even if there is not a relationship with anxiety and depression symptoms. Influence of periodontal tissue thickness on buccal plate remodelling on immediate implants with xenograft. Short-course radiotherapy with delayed surgery versus conventional chemoradiotherapy: A comparison of the short- and long-term outcomes in patients with T3 rectal cancer. With modern MRI systems, these structures are readily identified and can be appreciated in the context of multiligamentous knee injuries. An evaluation of a data linkage training workshop for research ethics committees. Learning words during shared book reading: The role of extratextual talk designed to increase child engagement. Preoperatively, a CT scan of the 3D skull model was performed without the removable flap. Contributing factors and outcomes of treatment refusal in pediatric oncology in Germany.

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However, compared to soil treatment, few remediation techniques have been commercially used for sediments. This illustrates the potential of clinical genomic profiling to improve diagnosis and enable specifically targeted therapies for cancers with complex pathologies. There has been controversy regarding the existence of BCH as a discrete disorder. Inspite of the decrease of total phenol content in investigated genotypes, as well as total antioxidant capacity, some of polyphenols were affected by stress like flavonoids chrysin, myricetine, kaempferol and isoferulic acid in roots of B229 genotype (Populus deltoides). Most clinical trials have reported after consolidation and maintenance therapy an increased PFS and even overall survival in some of them. However, the impact of specific ventilatory patterns on VILI is not well defined. Our study includes the performance evaluation of several state-of-the-art objective video quality metrics in terms of determining the quality of compressed WCE videos.

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Single-Center Comparison of Overall Survival and Toxicities in Patients with Infiltrative Hepatocellular Carcinoma Treated with Yttrium-90 Radioembolization or Drug-Eluting Embolic Transarterial Chemoembolization. Morphological irregularities of the meibomian glands and alterations to tear film secretions that affect tear evaporative dynamics were associated with symptoms of discomfort amongst the symptomatic lens wearers. Also, the body weight loss was less with LADM than with equivalent doses of free ADM. Temporal growth and spatial distribution of the fast food industry and its relationship with economic development in China - 2005-2012. The presence of cytosolic tyrosinase was dependent upon glycosylation of the molecule during synthesis in the ER. What is the Optimal Duration of Participation in a Community-Based Health Promotion Program for Older Adults?. Taken together, these results further support a role of this neurotransmitter in regulating human ovarian function. Basal cell adenomas are uncommon benign epithelial tumors of the salivary gland. Social networks in a sample of adolescents in Quebec: closeness of relations and personal adaptation.

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Comparison of wildfire smoke estimation methods and associations with cardiopulmonary-related hospital admissions. While venous anastomosis of superficial cerebral veins of 15 (30 sides) cadaveric heads was observed through blood vessel perfusion. Retrospective study on timing of resection of hepatocellular adenoma. Instead, amygdala activation correlates with metaphoricity, suggesting that the increase in emotional salience is specific to metaphoricity and is not simply a result of an overall increase in brain activity in regions associated with language comprehension. Elevated plus maze test showed a decrease in anxiety level in CBA mice and an increase in this parameter in BALB/c mice. We observed no statistical significant difference in functional outcome between patients with ORIF and patients with primary arthrodesis. The reconstruction of acetabular bone deficiency using autografts supported by an MC support ring provided satisfactory clinical and radiological results at 17.6 years postoperatively. The CORE self-management trial was approved by the London Camden and Islington Research Ethics Committee (REC ref: 12/LO/0988). The screen, therefore, has identified several new molecules that are critical for FcepsilonRI-induced degranulation.

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Chinese biomedical databases contain a large number of publications available to systematic reviewers, but it is unclear whether they are used for synthesizing the available evidence. Higher doses of THC were correlated with increased pain relief in some studies. The visualization of temporal bone specimens by digital tomosynthesis and CT images (slice thickness: 1.5 mm) was compared. Children and Young Adults Who Received Tracheostomies or Were Initiated on Long-Term Ventilation in PICUs. The aim of this paper is to describe the validation of the Rep(eat)-Q, a self-report measure developed to assess grazing, and investigates its relationship with BMI and psychopathology. Consequently, we have conducted this large-scale historical cohort study to provide relevant information rapidly to guide our current practice. Independent components analysis revealed that the latent factors that accounted for MFN activity to such changes also accounted for activity associated with the error-related negativity and the NoGo inhibitory N2. These results indicate that it is likely that phosphofructokinase (PFK) activity is enhanced in PAGGGM units relative to SAGM units. A comprehensive review of the scientific literature available in PubMed/Medline was conducted for studies on human genetics, experimental models and physiopathology related to teratozoospermia in particular globozoospermia, large headed spermatozoa and flagellar abnormalities.

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To review the research addressing the association of suicide and bullying, from childhood to young adulthood, including cross-sectional and longitudinal research findings. It is clear that activation of the proinflammatory cytokine cascade is both the cause and the consequence of renal injury. In order to isolate the influence of HIV-1 proteins and chronic stress on behavior and neuroinflammation, we employed the HIV-1 transgenic (Tg) rat model, which expresses HIV-1 proteins with a gag and pol deletion, allowing for viral protein expression without viral replication. Our aim was to describe the use of magnetic resonance image (MRI) in the study of PE and whether it is comparable to imaging techniques. In addition, it also increased the p53 expression and led to the generation of reactive oxygen species (ROS) in the cells. The preoperative Cys C level was higher in group 1 than in either group 2 or 3. International development partners (bilateral and multilateral) can help in this important effort to address NCDs and their shared risk factors by providing catalytic support to countries that are particularly vulnerable in terms of the disease burden but lack the resources (human, financial) and institutional arrangements to meet their commitments at national, regional, and global levels.

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Introduction to Gene Editing and Manipulation Using CRISPR/Cas9 Technology. Medical records of patients with nosocomial pneumonia caused by K. Two new non-spiny Solanum species from the Bolivian Andes (Morelloid Clade). Our hypothesis is that increasing disposable costs do not change outcome zithromax gel or operative time, but simply increases controllable cost. Antiproliferative effectiveness of lipid extracts and their neutral and polar fractions was evaluated on nine human cancer cell lines. Nodal Yield: Is it a Prognostic Factor for Head and Neck Squamous Cell Carcinoma?. Therefore, we need to select images for transfer that are pertinent to our specific purpose, to complete image transmission within a practically acceptable period of time.

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Translation and psychometric evaluation of the Swedish version of the Interdisciplinary Education Perception Scale. Membrane sections from each patient were immunostained for hypoxia-inducible factor 1alpha (HIF-1alpha) and CD68 (a pan-macrophage marker). The ratios of MeHg/THg in sediment were relatively small in comparison to those in other aqueous systems. Further exploration of this novel method of treatment, including the conduct of definitive randomised phase III clinical trials, is indicated in ovarian cancer and in other tumour types where clinical manifestations are principally localised to the peritoneal cavity. cholerae MAK 757 (El Tor, Ogawa) cells as well as on their VcA-1 lysogens but were unable to infect V.

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Clinical significance of several variations of the electrolyte equilibrium of the blood in relation to surgical intervention. Predictable pharmacokinetics, avoidance of routine laboratory monitoring, and lesser drug interactions have made NOACs safer and more tolerable treatment option in comparison to warfarin. Understanding the mechanisms that give rise to these complex patterns that vary both in space and time can be challenging, even in cases for which individual components have been identified. Immunohistochemical studies suggested that CTGF and VEGF are implicated in synovial hypertrophy with fibrosis. 72 operations (37 intervention, 35 control) were observed in full by 2 trained observers during two 3-month observation periods, before and after the intervention period. A SEM (structural equation modeling) model of age-related renal dysfunction suggests that proteinuria is a marker of renal damage, while urinary Kim-1 is a marker of both neurontin 300 mg cost damage and function.

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