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Aspitrate (Isosorbide)
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Aspitrate

Aspitrate is an inexpensive drug used to prevent chest pain caused by angina. It is more popular than comparable drugs. Aspitrate is only available as a generic drug; all brands have been discontinued.

Other names for this medication:
Aspitrate, Dilatrate, Ecosmin, Ismorin, Ismotic, Isoditrate, Isoloprin, Isordil, Isosorbide, Monit, Monoket, Monosprin, Nitren, Nitrofix, Nitroprin, Solosprin, Vasoprin

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Also known as: Isosorbide

Description

Aspitrate (isosorbide mononitrate) is a nitrate that dilates (widens) blood vessels, making it easier for blood to flow through them and easier for the heart to pump.

Aspitrate is an extended release tablet used to prevent angina attacks (chest pain).

Aspitrate will not treat an angina attack that has already begun.

Dosage

This section provides information on the proper use of a number of products that contain isosorbide mononitrate. It may not be specific to Aspitrate ER. Please read with care.

Take this medicine exactly as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered.

This form of nitrate is used to reduce the number of angina attacks over a long time. It will not relieve an attack that has already started because it works too slowly. The extended-release form gradually releases medicine to provide its effect for 8 to 10 hours. Check with your doctor if you also need a fast-acting medicine to relieve the pain of an angina attack.

You should take this medicine first thing in the morning and follow the same schedule each day. This medicine works best if you have a "drug-free" period of time every day when you do not take it. Your doctor will schedule your doses during the day to allow for a drug-free time. Follow the schedule of dosing carefully so the medicine will work properly.

Swallow the extended-release tablet whole with a half glass of water. Do not split, crush, or chew it.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For prevention of angina: For oral dosage form (extended-release tablets): Adults—At first, 30 or 60 milligrams (mg) once a day. Take the dose in the morning right after you wake up. Your doctor may increase your dose as needed. Children—Use and dose must be determined by your doctor. For oral dosage form (tablets): Adults—20 milligrams (mg) two times a day. Take the first dose in the morning right after you wake up, and the second dose 7 hours later. Children—Use and dose must be determined by your doctor.

Overdose

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of isosorbide mononitrate can be fatal.

Overdose symptoms may include a severe throbbing headache, fever, confusion, severe dizziness, fast or pounding heartbeats, vision problems, nausea, vomiting, stomach pain, bloody diarrhea, trouble breathing, sweating, cold or clammy skin, fainting, and seizure (convulsions).

Storage

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture and heat. Keep container tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Aspitrate are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Do not take Generic Aspitrate if you are allergic to Generic Aspitrate components. Do not take Generic Aspitrate if you're pregnant or you plan to have a baby. Do not use potassium supplements or salt substitutes. Be careful using Generic Aspitrate if you take dihydroergotamine (D.H.E. 45); or any other heart medicines, especially those used to treat high blood pressure or irregular heartbeats. Be careful using Generic Aspitrate if you suffer from or have a history of congestive heart failure, have low blood pressure; a stroke, a transient ischemic attack (TIA, or mini-stroke), have anemia; have an allergy to nitrates; have closed-angle glaucoma; migraines, kidney disease; liver disease, heart attack, a serious head injury. If you want to achieve most effective results without any side effects it is better to avoid alcohol. Be very careful when you are driving machine. Do not stop taking Generic Aspitrate suddenly.

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Results suggested that moderate and high use of sexting could be a risk factor for some problematic behaviors such as dating violence, even if there is not a relationship with anxiety and depression symptoms. Influence of periodontal tissue thickness on buccal plate remodelling on immediate implants with xenograft. Short-course radiotherapy with delayed surgery versus conventional chemoradiotherapy: A comparison of the short- and long-term outcomes in patients with T3 rectal cancer. With modern MRI systems, these structures are readily identified and can be appreciated in the context of multiligamentous knee injuries. An evaluation of a data linkage training workshop for research ethics committees. Learning words during shared book reading: The role of extratextual talk designed to increase child engagement. Preoperatively, a CT scan of the 3D skull model was performed without the removable flap. Contributing factors and outcomes of treatment refusal in pediatric oncology in Germany.

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Single-Center Comparison of Overall Survival and Toxicities in Patients with Infiltrative Hepatocellular Carcinoma Treated with Yttrium-90 Radioembolization or Drug-Eluting Embolic Transarterial Chemoembolization. Morphological irregularities of the meibomian glands and alterations to tear film secretions that affect tear evaporative dynamics were associated with symptoms of discomfort amongst the symptomatic lens wearers. Also, the body weight loss was less with LADM than with equivalent doses of free ADM. Temporal growth and spatial distribution of the fast food industry and its relationship with economic development in China - 2005-2012. The presence of cytosolic tyrosinase was dependent upon glycosylation of the molecule during synthesis in the ER. What is the Optimal Duration of Participation in a Community-Based Health Promotion Program for Older Adults?. Taken together, these results further support a role of this neurotransmitter in regulating human ovarian function. Basal cell adenomas are uncommon benign epithelial tumors of the salivary gland. Social networks in a sample of adolescents in Quebec: closeness of relations and personal adaptation.

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