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Aratan (Losartan)
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Aratan

Aratan belongs to a group of drugs called angiotensin II receptor antagonists (sometimes called ARB blockers). It keeps blood vessels from narrowing, which lowers blood pressure and improves blood flow. Aratan is used to treat high blood pressure (hypertension) in adults and children who are at least 6 years old. It is also used to lower the risk of stroke in certain people with heart disease.

Other names for this medication:
Angilock, Angizaar, Anreb, Araten, Asart, Biortan, Cartan, Corodin, Cozzar, Czartan, Enromic, Hilos, Insaar, Klosartan, Lacine, Logika, Losagen, Losaprex, Losartax, Losartil, Losazid, Losium, Lostan, Lostankal, Lostat, Lotan, Loxibin, Lozap, Maxartan, Omnitan, Psycholanz, Resilo, Sanipresin, Sarilen, Sartens, Sedeten, Tacicul, Tarnasol, Tensiohess, Tiasar

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Also known as: Losartan

Description

Aratan (losartan potassium) is an angiotensin II receptor blocker acting on the AT1 receptor subtype. Losartan potassium, a non-peptide molecule, is chemically described as 2-butyl-4-chloro-1-[p-(o-1Htetrazol- 5-ylphenyl)benzyl]imidazole-5-methanol monopotassium salt.

Aratan is a white to off-white free-flowing crystalline powder with a molecular weight of 461.01. It is freely soluble in water, soluble in alcohols, and slightly soluble in common organic solvents, such as acetonitrile and methyl ethyl ketone. Oxidation of the 5-hydroxymethyl group on the imidazole ring results in the active metabolite of losartan.

Aratan is available as tablets for oral administration containing either 25 mg, 50 mg or 100 mg of losartan potassium and the following inactive ingredients: microcrystalline cellulose, lactose hydrous, pregelatinized starch, magnesium stearate, hydroxypropyl cellulose, hypromellose, and titanium dioxide.

Aratan 25 mg, 50 mg and 100 mg tablets contain potassium in the following amounts: 2.12 mg (0.054 mEq), 4.24 mg (0.108 mEq) and 8.48 mg (0.216 mEq), respectively. Aratan 25 mg, Aratan 50 mg, and Aratan 100 mg may also contain carnauba wax.

Dosage

Take Aratan tablets orally with or without food. Do not crush or chew it. Take Aratan once or twice a day at the same time. If you want to achieve most effective results do not stop taking Aratan suddenly.

Overdose

If you overdose Aratan and you don't feel good you should visit your doctor or health care provider immediately. Symptoms of Aratan overdosage: fainting, feeling lightheaded, rapid heartbeat.

Storage

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture, light and heat. Keep container tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children in a container that small children cannot open.

Side effects

The most common side effects associated with Aratan are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Drinking alcohol can further lower your blood pressure and may increase certain side effects of Aratan.

Do not use potassium supplements or salt substitutes, unless your doctor has told you to.

Avoid getting up too fast from a sitting or lying position, or you may feel dizzy.

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It was found that in a serum-free medium, cobra NGF prevented the death of PC12 cells with efficacy comparable to that of NGF from mouse submaxillary glands. Optimization criteria of the mechanism governing the stability of the membrane potential. Limited signal transduction repertoire of human Y(5) neuropeptide Y receptors expressed in HEC-1B cells. Many observations indicate that the retrograde and local destination transfer of hormones and other biologically active substances may be a universal physiological regulatory mechanism, operating with only minor modifications in various species of animals and in humans. The perturbation due to a tracer in a biomedical system usually leads to a linear system that can be described by a compartmental matrix. A residence hall tavern as a collegiate alcohol abuse prevention activity. Kinetic analyses of the inhibition in the absence and presence of heparin were conducted by employing the p-nitroanilide of a synthetic peptide, S-2238, to determine residual thrombin activity. Additionally, the PLA to detect EGFR-GRB2 interaction was evaluated as a prognostic marker in two cohorts of patients with lung adenocarcinoma. Therefore, in tumor cells, MAP17 could be a marker for increased oxidative stress and could define new therapeutic approaches. To determine whether the association between Hcy and fractures is explained by an altered methylation capacity, we investigated the associations between levels of s-adenosylmethionine (SAM) and S-adenosylhomocysteine (SAH) and fracture risk.

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There is accumulating evidence supporting the use of cell therapy for cardiac repair. The background of SIRT1 and miRNAs will be summarized, followed by the mechanism by which several key miRNAs alter SIRT1 levels, and how the RBP HuR regulates SIRT1. Studies on enzymatic activity in serum obtained from muscular dystrophic patients. The incidence of slow flow after rotational atherectomy of calcified coronary arteries: A randomized study of low speed versus high speed. This review attempts to describe the biological chemistry of S-nitrosation and to point out where the challenges lie in matching the known chemical biology of these compounds with their reported functions. Such efforts have produced several notable success stories that involve rapidly moving biomarkers from the bench to the clinic. Active euthanasia in pre-modern society, 1500-1800: learned debates and popular practices. Non specific abnormalities of immune system parameters found in serum of 38 patients with idiopathic posterior uveitis can indicate their role in pathogenesis of this disease.

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The toxin complex (tc) genes of Photorhabdus encode insecticidal, high molecular weight Tc toxins. An overview of so far published analyses comparating the effectiveness of the treatment with insulin pump and multiple daily injections in type 1 diabetes mellitus. Dispersion relations, electroencephalographic spectra, and stimulus response functions are calculated from the underlying physiology, and the effects of discrete mode structure are determined. To address these challenges, we propose a framework enabling efficient implementation of meaningful CDS that incorporates a large variety of clinical knowledge models to bring to the clinic comprehensive solutions leveraging the latest domain knowledge. The objective of this study is to assess the impact of HBoV viral load on clinical characteristics in children who were HBoV positive and suffered severe LRTI. The expression of FAK and p-FAK in cutaneous incised wound in mouse were investigated by immunohistochmeistry and Western blotting. The rectum, bladder, and ureters of 12 female pigs were injured with four different laparoscopic energy sources. We show that this approach is able to infer general rules for interaction, or lack of interaction, among members of a flock or, more generally, any community. III.1.b Analysis of total N-nitroso compounds as a group by denitrosation to nitric oxide, with detection using a chemiluminescence analyser. The relatively long plasma half-life, of approximately 50 h, makes it suitable for once-daily dosing.

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ANESTHESIA LXVIII: THE ANESTHETIC INDEX OF VOLATILE ANESTHETICS. Both insect-adapted and alternated lineages greatly increased in their ability to infect insect cells. This paper provides a description of the structure of the Northern Outreach program, program objectives and approaches towards meeting the objectives. Catheter treatment for hypertrophic obstructive cardiomyopathy: for seniors only?. Proteins from Anthozoa species are homologous to the green fluorescent protein (GFP) from Aequorea victoria but with absorption/emission properties extended to longer wavelengths. The mechanisms used by Lysozyme in the modulation of immunological responses during viral hepatitis are discussed. This study was aimed at using chromosome painting technique to detect translocation, especially microtranslocations, on chromosomes in comparison with G-banding analysis. Fifty patients with a mean age of 35 years were treated with open reduction and PDS cerclage augmentation.

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Starting with the description of the structure and physiology of normal arteries and of atherosclerotic lesions some of the current theories on the mechanisms of atherosclerosis are considered. Adopting a common set of valid and explicit methods across international societies could harmonize recommendations and facilitate guideline implementation. Overlapping neural substrates between intentional and incidental down-regulation of negative emotions. Activity level in culture supernatants was elevated by phorbol myristate acetate. Antireticular cytotoxic serum or Bogomoletz serum in therapy of cerebral concussion. Ontogenetic development of T- and B-lymphocytes and non-lymphoid cells in the white pulp of the rat spleen. Ump1/POMP is associated with precursor intermediates and degraded upon final maturation.

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Primary outcomes measured included intraoperative vascular complications, estimated operative blood loss, and operative mortality. Conventional echocardiographic assessment of the canine right heart: reference intervals and repeatability. This hemodialysis-associated thrombocytopenia was ameliorated by changing the dialyzer in use. A program for the prevention is it ok to take lexapro while breastfeeding of cardiovascular diseases within the framework of adult education. Only where the coat is, for some reason, missing can microvilli be seen on freeze-dried cells. Disparities in the syphilis trends among MSM were also noted, with greater increases observed among HIV-positive MSM than HIV-negative MSM in both the US and Western Europe.

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Corrigendum to: Approaches to management of complaints and notifications about health practitioners in Australia. Dendrite-like Co3O4 nanostructure and its applications in sensors, supercapacitors and catalysis. We applied the technique to measure the strain energy of highly invasive MDA-MB-231 breast carcinoma and A-125 lung carcinoma cells in collagen gels. Both keto groups form additional intra- and intermolecular C-H.O contacts with H.O distances ranging from 2.26 to 2.41 A. Originally it was believed to arise from type II alveolar cells which invade blood vessels within the lung, and hence its name. The electrophysiological study consisted of PERG and PEV within 20 days of the episode. Abnormalities of respiratory gases in synovial fluid of patients with juvenile rheumatoid arthritis.

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