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Aratan (Losartan)

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Aratan belongs to a group of drugs called angiotensin II receptor antagonists (sometimes called ARB blockers). It keeps blood vessels from narrowing, which lowers blood pressure and improves blood flow. Aratan is used to treat high blood pressure (hypertension) in adults and children who are at least 6 years old. It is also used to lower the risk of stroke in certain people with heart disease.

Other names for this medication:
Angilock, Angizaar, Anreb, Araten, Asart, Biortan, Cartan, Corodin, Cozzar, Czartan, Enromic, Hilos, Insaar, Klosartan, Lacine, Logika, Losagen, Losaprex, Losartax, Losartil, Losazid, Losium, Lostan, Lostankal, Lostat, Lotan, Loxibin, Lozap, Maxartan, Omnitan, Psycholanz, Resilo, Sanipresin, Sarilen, Sartens, Sedeten, Tacicul, Tarnasol, Tensiohess, Tiasar

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Also known as: Losartan


Aratan (losartan potassium) is an angiotensin II receptor blocker acting on the AT1 receptor subtype. Losartan potassium, a non-peptide molecule, is chemically described as 2-butyl-4-chloro-1-[p-(o-1Htetrazol- 5-ylphenyl)benzyl]imidazole-5-methanol monopotassium salt.

Aratan is a white to off-white free-flowing crystalline powder with a molecular weight of 461.01. It is freely soluble in water, soluble in alcohols, and slightly soluble in common organic solvents, such as acetonitrile and methyl ethyl ketone. Oxidation of the 5-hydroxymethyl group on the imidazole ring results in the active metabolite of losartan.

Aratan is available as tablets for oral administration containing either 25 mg, 50 mg or 100 mg of losartan potassium and the following inactive ingredients: microcrystalline cellulose, lactose hydrous, pregelatinized starch, magnesium stearate, hydroxypropyl cellulose, hypromellose, and titanium dioxide.

Aratan 25 mg, 50 mg and 100 mg tablets contain potassium in the following amounts: 2.12 mg (0.054 mEq), 4.24 mg (0.108 mEq) and 8.48 mg (0.216 mEq), respectively. Aratan 25 mg, Aratan 50 mg, and Aratan 100 mg may also contain carnauba wax.


Take Aratan tablets orally with or without food. Do not crush or chew it. Take Aratan once or twice a day at the same time. If you want to achieve most effective results do not stop taking Aratan suddenly.


If you overdose Aratan and you don't feel good you should visit your doctor or health care provider immediately. Symptoms of Aratan overdosage: fainting, feeling lightheaded, rapid heartbeat.


Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture, light and heat. Keep container tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children in a container that small children cannot open.

Side effects

The most common side effects associated with Aratan are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Drinking alcohol can further lower your blood pressure and may increase certain side effects of Aratan.

Do not use potassium supplements or salt substitutes, unless your doctor has told you to.

Avoid getting up too fast from a sitting or lying position, or you may feel dizzy.

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An unusual cause of hoarseness and recurrent laryngeal nerve palsy. THE EFFECT OF VITAMIN D ON THE DENTINE OF THE INCISOR TEETH AND ON THE ALVEOLAR BONE OF YOUNG RATS MAINTAINED ON DIETS DEFICIENT IN CALCIUM OR PHOSPHORUS. Ferromagnetic phase transition in a Heisenberg fluid: Monte Carlo simulations and Fisher corrections to scaling. This adds a new determinant, situated near the hemoglobin binding site, to the three determinants reported in the literature. De novo synthesis of PE must not be sufficient to support optimum growth in Etn-responsive cells. We conducted a cross-sectional study using data on 58,590 individuals 65 years of age or older from the Korean Community Health Survey 2013.

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GLOBULIN-MODIFIED VACCINATION WITH LIVE ATTENUATED MEASLES VIRUS, SUGIYAMA, ADAPTED TO BOVINE RENAL CELLS. Different parameters for normal tissue radiation tolerance presented in the literature were used. Remus discriminated ten toxin-responsive transcripts associated with the inheritance of DON resistance and Fhb1. GSHTf did not exhibit peroxidase activity and did not show a compensatory increase when Se dependent GSHPx activity was low. Altogether, our results show compelling evidence of recent purifying selection acting on both characterized and predicted lncRNAs. Here, we report upon the identification and characterization of three muscleblind-like genes in zebrafish (zmbnl1, zmbnl2 and zmbnl3). offer many advantages as model bacteria for the study of spirochaetes. A model for achievement motives, goal orientations, intrinsic interest, and academic achievement. However, the ratio between the relative risks in the medical studies and in the Japanese data tends to diminish with increasing average or maximal therapy dose. While NT-proBNP is an established biomarker for heart failure of non-congenital origin, its value in ACHD has limitations.

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No substantial effects of CO2 levels on bacterial community composition were detected. Vitamin D intervention in preschoolers with viral-induced asthma (DIVA): a pilot randomised controlled trial. These observations suggest that the cellular reduction and oxidation (redox) state modified by TRX is involved in the BLM resistancy and the induction of TRX in bronchial epithelial cells might play a protective role in BLM-induced lung injury. An explanation for this is that cardiac reside stem cells are present throughout the infarction site but die rapidly by apoptosis. Additionally, in anurans, it was found that a subset of large diameter, myelinated fibers take up a random arrangement in the nerve.

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These observations suggest that the facial muscular apparatus of the monkey has extensive homology to the human face. Sinus of valsalva aneurysm is a rare condition arising from any of the three aortic sinuses. Productivity of registered nurses in home health care: a nationwide survey. Patients with suspected small bowel tumours, who underwent Endoscopic Ultrasonography performed during Double Balloon Enteroscopy in our Institution between 2005 and 2013, were reviewed. Suicide and addictive characteristics of spouses with alcohol dependence according to the marriage dynamics. On the taxonomy of wounds in road traffic: clothing and skin wounds. Thickening of the flocculent suspensions was investigated, leading to determination of the capacity curves of the settler. Indeed, cohesin performs critical roles in gene regulation, possibly through the formation of higher-order chromatin structure. Histological appearance of the basement membrane of the epidermis in eczema and in Duhring-Brocq dermatitis.

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Hepatic monocytes other than macrophages showed the increased expression of inflammatory cytokines and chemokines in the hyperglycemic mice. Recent contributions of women medical specialists to military medicine. Effect of adrenal medullectomy on the activity of COMT and MAO in adrenal cortex of control and stressed rats. HSP70 expression was detected by immunohistochemistry (IHC) and Western blotting (WB). Reviewing the principles of clinical trial design relevant to neuromodulation and using perinatal stroke as a model, this article reviews the current and future issues of advancing such trials in children. The forearm basilic vein is rarely used for creating autogenous vascular access. In ovary preparations, the inhibitor is retained by dialysis tubing and is heat sensitive, whereas in egg extracts it is diffusable and heat stable. Evidence of partial domain nucleation, propagation, and switching even at applied electric fields below the estimated coercive field is revealed. We systematically reviewed the literature to retrieve data on the prevalence of IM in different countries and performed an ecological analysis to quantify the association between the prevalence of IM among infected subjects and smoking, using data on national tobacco availability.

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In the two-compartment cultivation system, an entire or only a half root system of a maize plant was inoculated with an AMF, Rhizophagus intraradices, in the presence of localized or systemic drought treatment. Antimicrobial prophylaxis does not seem to reduce morbidity after removal of lower third molars. Patients commonly enter investigational trials, many of which use radiographic response as an endpoint for assessing drug efficacy. manual jet ventilation during bronchoscopy in patients with tracheo-bronchial stenosis. Rat kidney GSH, rat liver GST, and human red blood cell GST levels have been found to positively correlate with G6PD levels in their respective tissues. Recombinant ficolin-B bound to immobilized acetylated bovine serum albumin interacted with recombinant human mannan-binding lectin-associated serine protease-2, which led to C4 cleavage, thus demonstrating the capability of ficolin-B to activate the lectin pathway. Correlation of early CT signs in the deep middle cerebral artery territories with angiographically confirmed site of arterial occlusion. Five of six had hepatomegaly, and there was one case each of hepatic abscess, infarcts, and hemochromatosis. Data were collected on the mother-baby unit of an academic medical center in the Northeastern United States. To enhance self-management in outpatients, a multi-component intervention was developed, integrating patient self-management and professional care through healthcare technology.

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alpha-Thujone was converted to 4-hydroxy-alpha- and -beta-thujones via the 3,4-enol acetate on oxidation with peracid and osmium tetroxide, respectively. Although PPCM is considered to be comparable to PCM regarding its analgesic properties, injection pain is a common side effect described for PPCM but not PCM. Hand hygiene (HH) is a primary practice used to reduce the risk and spread of infection. The Incidence of Perioperative Adverse Events in the Very Elderly Undergoing Urogynecologic Surgery. They were those eggs which were unable to develop near the lower limits of the temperature range characteristic of B. Anomalous scaling in two models of passive scalar advection: effects of anisotropy and compressibility.

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It was found that in a serum-free medium, cobra NGF prevented the death of PC12 cells with efficacy comparable to that of NGF from mouse submaxillary glands. Optimization criteria of the mechanism governing the stability of the membrane potential. Limited signal transduction repertoire of human Y(5) neuropeptide Y receptors expressed in HEC-1B cells. Many observations indicate that the retrograde and local destination transfer of hormones and other biologically active substances may be a universal physiological regulatory mechanism, operating with only minor modifications in various species of animals and in humans. The perturbation due to a tracer in a biomedical system usually leads to a linear system that can be described by a compartmental matrix. A residence hall tavern as a collegiate alcohol abuse prevention activity. Kinetic analyses of the inhibition in the absence and presence of heparin were conducted by employing the p-nitroanilide of a synthetic peptide, S-2238, to determine residual thrombin activity. Additionally, the PLA to detect EGFR-GRB2 interaction was evaluated as a prognostic marker in two cohorts of patients with lung adenocarcinoma. Therefore, in tumor cells, MAP17 could be a marker for increased oxidative stress and could define new therapeutic approaches. To determine whether the association between Hcy and fractures is explained by an altered methylation capacity, we investigated the associations between levels of s-adenosylmethionine (SAM) and S-adenosylhomocysteine (SAH) and fracture risk.

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There is accumulating evidence supporting the use of cell therapy for cardiac repair. The background of SIRT1 and miRNAs will be summarized, followed by the mechanism by which several key miRNAs alter SIRT1 levels, and how the RBP HuR regulates SIRT1. Studies on enzymatic activity in serum obtained from muscular dystrophic patients. The incidence of slow flow after rotational atherectomy of calcified coronary arteries: A randomized study of low speed versus high speed. This review attempts to describe the biological chemistry of S-nitrosation and to point out where the challenges lie in matching the known chemical biology of these compounds with their reported functions. Such efforts have produced several notable success stories that involve rapidly moving biomarkers from the bench to the clinic. Active euthanasia in pre-modern society, 1500-1800: learned debates and popular practices. Non specific abnormalities of immune system parameters found in serum of 38 patients with idiopathic posterior uveitis can indicate their role in pathogenesis of this disease.

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The toxin complex (tc) genes of Photorhabdus encode insecticidal, high molecular weight Tc toxins. An overview of so far published analyses comparating the effectiveness of the treatment with insulin pump and multiple daily injections in type 1 diabetes mellitus. Dispersion relations, electroencephalographic spectra, and stimulus response functions are calculated from the underlying physiology, and the effects of discrete mode structure are determined. To address these challenges, we propose a framework enabling efficient implementation of meaningful CDS that incorporates a large variety of clinical knowledge models to bring to the clinic comprehensive solutions leveraging the latest domain knowledge. The objective of this study is to assess the impact of HBoV viral load on clinical characteristics in children who were HBoV positive and suffered severe LRTI. The expression of FAK and p-FAK in cutaneous incised wound in mouse were investigated by immunohistochmeistry and Western blotting. The rectum, bladder, and ureters of 12 female pigs were injured with four different laparoscopic energy sources. We show that this approach is able to infer general rules for interaction, or lack of interaction, among members of a flock or, more generally, any community. III.1.b Analysis of total N-nitroso compounds as a group by denitrosation to nitric oxide, with detection using a chemiluminescence analyser. The relatively long plasma half-life, of approximately 50 h, makes it suitable for once-daily dosing.

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We sought to determine whether there is an association between total and specific IgE to a variety of allergens in polyp and nonpolyp tissue and markers of eosinophilic inflammation or skin test results. The excited electronic state of interest is formed by photoemission of an electron from one Ag cluster and transient attachment of the photoemitted electron to the adsorbed water molecule. A new species, Triplophysa huapingensis, is described from the Hongshuihe River, Guangxi, China. To evaluate the effect of various head and neck positions on intrathoracic pressure and arterial oxygenation during exercise in horses. They contained carboxyfluorescein in the aqueous core and fluorescein-labeled lipids in the bilayer to render them both a surface and volume fluorescer, maximizing their fluorescence intensity. Comparison of CT and angiography in assessing resectability of pancreatic carcinoma. The role of imuran lupus patient reviews POK in post-Golgi endomembrane trafficking and as a member of a putative plant GARP/VFT complex is discussed. Anatomical reduction, stable fixation and early functional movement of the joint are the three cornerstones of modern treatment concepts of distal radius fractures.

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Autopsy showed an anomalous origin of the left coronary artery from the right sinus of Valsalva. Furthermore, the presence of an encapsulating carbonaceous layer inhibits processes that cause beam damage, markedly increasing the dose rate threshold for the accumulation of damage. Finally, there were drastically reduced numbers and motility of epididymal sperm from Bbx-null rats. Histochemical study of the mucosubstances in the canine stomach. In the experimental conditions, a second evoked potential, the EACC, was also recorded after the change in stimulating electrode. One hundred and forty-five patients suffering from the AEs were reviewed retrospectively and 105 patients of them were provided guidance on home exercise and activities of daily living based partially on a cognitive-behavioral approach. The complete area of the proximal femur can be scanned except at the femoral head, which interferes with the ilium. Comparison of cardiolipin spectra, using vector algebra, showed that inactivation of tafazzin had a large effect on the molecular composition of cardiolipin, inactivation of calcium-independent phospholipase A(2) had a small effect, whereas inactivation of acyl-CoA:lysocardiolipin-acyltransferase and of the trifunctional enzyme did not affect the cardiolipin composition. We describe a case demonstrating that coronary artery dissection, even when initially asymptomatic, may later progress and result in significant or complete coronary occlusion.

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ANESTHESIA LXVIII: THE ANESTHETIC INDEX OF VOLATILE ANESTHETICS. Both insect-adapted and alternated lineages greatly increased in their ability to infect insect cells. This paper provides a description of the structure of the Northern Outreach program, program objectives and approaches towards meeting the objectives. Catheter treatment for hypertrophic obstructive cardiomyopathy: for seniors only?. Proteins from Anthozoa species are homologous to the green fluorescent protein (GFP) from Aequorea victoria but with absorption/emission properties extended to longer wavelengths. The mechanisms used by Lysozyme in the modulation of immunological responses during viral hepatitis are discussed. This study was aimed at using chromosome painting technique to detect translocation, especially microtranslocations, on chromosomes in comparison with G-banding analysis. Fifty patients with a mean age of 35 years were treated with open reduction and PDS cerclage augmentation.

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Ingesting a pre-workout supplement containing caffeine, B-vitamins, amino acids, creatine, and ceclor davis drug guide beta-alanine before exercise delays fatigue while improving reaction time and muscular endurance. The findings are discussed within probabilistic and predictive coding frameworks of multi-sensory integration underlying a coherent sense of self. This approach concerns not only the differences in the composition of the media applied but also primarily emphasizes the concrete parts of the immunofluorescence protocol determining accurate results. To determine the FSAP genotypes, an amplification created restriction site (ACRS) PCR test was developed. Taken together, these data indicate that puc modulates gene expression responses by antagonizing a Rho GTPase signal transduction pathway that stabilizes the AP-1 transcription factor. The change in cortisol concentrations (Delta-cortisol) was calculated for each dog. The cell wall structure, arrangement of photosynthetic membranes, and the attachment of flagella of Ectothiorhodospira mobilis strain 8112 were examined by using freeze-etching and conventional electron microscopic techniques. Secondary end-points include: infarct growth (expansion of the diffusion-weighted imaging lesion) from baseline to the 24-h and one-month follow-up examination. We review data that demonstrate the ability of these molecules to accelerate blastocyst differentiation and delineate the respective intracellular signaling pathways that advance the embryonic developmental program.

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We addressed these issues using 11 additional years of follow-up of the Harvard Six Cities study, incorporating recent lower exposures. For Study 1, 200 digital profile face photographs of active Facebook users were randomly selected from native and immigrant Taiwanese and Americans. In addition, these results suggested a dissociation between local and central adaptations. The incidence of inflammatory bowel disease in children in western countries may be rising. The technique of ERCP can levaquin 500 mg once daily easily be modified to avoid repeated pancreatic duct injection and, by doing so, an increase in the incidence of acute pancreatitis has been reversed. When tested for analgesic responding to morphine in the presence of the compound CS, only those groups for which the CS and morphine injections were paired during the acquisition sequence evidenced tolerance. Utilizing three student (Study 1) and non-student samples (Study 2), we examined cultural differences in workplace choice for North Americans, Germans, and Japanese.

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Starting with the description of the structure and physiology of normal arteries and of atherosclerotic lesions some of the current theories on the mechanisms of atherosclerosis are considered. Adopting a common set of valid and explicit methods across international societies could harmonize recommendations and facilitate guideline implementation. Overlapping neural substrates between intentional and incidental down-regulation of negative emotions. Activity level in culture supernatants was elevated by phorbol myristate acetate. Antireticular cytotoxic serum or Bogomoletz serum in therapy of cerebral concussion. Ontogenetic development of T- and B-lymphocytes and non-lymphoid cells in the white pulp of the rat spleen. Ump1/POMP is associated with precursor intermediates and degraded upon final maturation.

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Series of complexes bearing the acridine-9-carboxylate chromophore displayed higher cytotoxic effect than acridine-9-carboxamide complexes, with gradual effect according to the size of the polymethylene linker. High-affinity disaccharide binding by tricyclic synthetic lectins. In fact, we are unable to deduce the principles of frequency selectivity in the frog auditory endorgan. We included 200 patients, 98 sensitized to any pollen and 9 to V vinifera pollen. Alternative ketogenic diets in glucose transporter type 1 deficiency syndrome. The aim of this study was to determine whether there is more deterioration in walking under dual-task conditions in patients with bilateral vestibular loss (BVL) than in healthy subjects, as opposed to the findings after unilateral loss. The expression of genes that had been found to be differentially regulated in betaB1-crystallin-MYOC mice was further analyzed in cultured human trabecular meshwork (HTM) cells treated with recombinant myocilin. It is minimally invasive, results in less animal pain and distress, requires less procedural and recovery time, and is inexpensive.

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Furthermore, the need for careful preoperative imaging in patients undergoing semilunar valve replacement is essential. Needs assessment and evaluation of GIRAnet will provide a greater understanding of how to develop and sustain such knowledge-exchange networks. The ability to image the cord directly rather than indirectly as in myelography, the absence of bone artifact as in computed tomography, and the multiplanar capabilities indicate that MRI will be the procedure of choice in the examination of the spinal cord. Cord Compression due to Extramedullary Hematopoiesis in an Adolescent with Known Beta Thalassemia Major. Technic and results of surgical interventions on sympathetic nervous system. Green-light laser en bloc resection for primary non-muscle-invasive bladder tumor versus transurethral electroresection: A prospective, nonrandomized two-center trial with 36-month follow-up. Reproductive potential predicts longevity of female Mediterranean fruitflies. bacteriophora hermaphrodites, but rather are present in the most posterior-intestinal cells. Evaluation of simplified mass transfer models to simulate the impacts of source zone architecture on nonaqueous phase liquid dissolution in heterogeneous porous media. The results showed that the congruency effects from distracting lights followed the hand around in space in normal people, but failed to do so in the split-brain patient when the hand crossed the midline.

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Primary outcomes measured included intraoperative vascular complications, estimated operative blood loss, and operative mortality. Conventional echocardiographic assessment of the canine right heart: reference intervals and repeatability. This hemodialysis-associated thrombocytopenia was ameliorated by changing the dialyzer in use. A program for the prevention is it ok to take lexapro while breastfeeding of cardiovascular diseases within the framework of adult education. Only where the coat is, for some reason, missing can microvilli be seen on freeze-dried cells. Disparities in the syphilis trends among MSM were also noted, with greater increases observed among HIV-positive MSM than HIV-negative MSM in both the US and Western Europe.

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Corrigendum to: Approaches to management of complaints and notifications about health practitioners in Australia. Dendrite-like Co3O4 nanostructure and its applications in sensors, supercapacitors and catalysis. We applied the technique to measure the strain energy of highly invasive MDA-MB-231 breast carcinoma and A-125 lung carcinoma cells in collagen gels. Both keto groups form additional intra- and intermolecular C-H.O contacts with H.O distances ranging from 2.26 to 2.41 A. Originally it was believed to arise from type II alveolar cells which invade blood vessels within the lung, and hence its name. The electrophysiological study consisted of PERG and PEV within 20 days of the episode. Abnormalities of respiratory gases in synovial fluid of patients with juvenile rheumatoid arthritis.

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