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Angilock (Losartan)

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Angilock belongs to a class of drugs called angiotensin receptor blockers (ARBs). It works by relaxing blood vessels so that blood can flow more easily. It is taken by mouth. It may be used alone or in addition to other blood pressure medication.

Other names for this medication:
Angibloc, Asart, Cozaarex, Cozzar, Czartan, Faxiven, Fortzaar, Forzaar, Hizaar, Lohyp, Losacor, Losadrac, Losakind, Losan, Losapot, Losaprex, Losargamma, Losartax, Losatan, Losatrix, Losazide, Lozar, Maxartan, Mozartan, Ocsaar, Repace, Sarvastan, Satoren, Sedeten, Tacicul, Temisartan, Tensartan, Tozaar

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Also known as: Losartan


Angilock (losartan potassium) is an angiotensin II receptor blocker acting on the AT1 receptor subtype. Losartan potassium, a non-peptide molecule, is chemically described as 2-butyl-4-chloro-1-[p-(o-1Htetrazol- 5-ylphenyl)benzyl]imidazole-5-methanol monopotassium salt.

Angilock is a white to off-white free-flowing crystalline powder with a molecular weight of 461.01. It is freely soluble in water, soluble in alcohols, and slightly soluble in common organic solvents, such as acetonitrile and methyl ethyl ketone. Oxidation of the 5-hydroxymethyl group on the imidazole ring results in the active metabolite of losartan.

Angilock is available as tablets for oral administration containing either 25 mg, 50 mg or 100 mg of losartan potassium and the following inactive ingredients: microcrystalline cellulose, lactose hydrous, pregelatinized starch, magnesium stearate, hydroxypropyl cellulose, hypromellose, and titanium dioxide.

Angilock 25 mg, 50 mg and 100 mg tablets contain potassium in the following amounts: 2.12 mg (0.054 mEq), 4.24 mg (0.108 mEq) and 8.48 mg (0.216 mEq), respectively. Angilock 25 mg, Angilock 50 mg, and Angilock 100 mg may also contain carnauba wax.


Usual Adult Dose for Diabetic Nephropathy:

Initial dose: 50 mg orally once a day Maximum dose: 100 mg orally once a day Comments: -If hypertensive patients with left ventricular hypertrophy or type 2 diabetic nephropathy patients require titration from initial dose, increase to 100 mg orally once a day. -Antihypertension is substantially present within 1 week but in some studies the maximal effect occurred in 3 to 6 weeks. Uses: -Treatment of hypertension. -To reduce the risk of stroke in patients with hypertension and left ventricular hypertrophy. -Treatment of diabetic nephropathy with an elevated serum creatinine and proteinuria (urinary albumin to creatinine ratio 300 mg/g or greater) in patients with type 2 diabetes and a history of hypertension.

Usual Adult Dose for Hypertension:

Initial dose: 50 mg orally once a day Maximum dose: 100 mg orally once a day Comments: -If hypertensive patients with left ventricular hypertrophy or type 2 diabetic nephropathy patients require titration from initial dose, increase to 100 mg orally once a day. -Antihypertension is substantially present within 1 week but in some studies the maximal effect occurred in 3 to 6 weeks. Uses: -Treatment of hypertension. -To reduce the risk of stroke in patients with hypertension and left ventricular hypertrophy. -Treatment of diabetic nephropathy with an elevated serum creatinine and proteinuria (urinary albumin to creatinine ratio 300 mg/g or greater) in patients with type 2 diabetes and a history of hypertension.

Usual Pediatric Dose for Hypertension:

6 Years or Older: Initial dose: 0.7 mg/kg orally once a day (up to 50 mg total) Comments: -May be given as a tablet or suspension. -Doses above 1.4 mg/kg (or 100 mg) daily have not been studied in pediatric patients.

Detailed Angilock dosage information


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.


Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture, light and heat. Keep container tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children in a container that small children cannot open.

Side effects

The most common side effects associated with Angilock are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Changes in renal function including acute renal failure can be caused by drugs that inhibit the reninangiotensin system and by diuretics. Patients whose renal function may depend in part on the activity of the renin-angiotensin system (e.g., patients with renal artery stenosis, chronic kidney disease, severe congestive heart failure, or volume depletion) may be at particular risk of developing acute renal failure on COZAAR. Monitor renal function periodically in these patients. Consider withholding or discontinuing therapy in patients who develop a clinically significant decrease in renal function on Angilock.

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Trisomy 6 and trisomy 6 mosaicism were found in chorionic villi cell culture and short term incubation in a prenatal diagnosis at 12 weeks of gestation in a pregnancy with a growth retarded fetus showing nuchal translucency. The binding site for eIF-3 on the small ribosomal subunit was studied (a) by use of a complex of eIF-3 and derived 40 S ribosomal subunit from rat liver, and (b) by use of native small ribosomal subunits from rabbit reticulocytes. Ethylene plays a critical role in the bacterial pathogen Xanthomonas euvesicatoria (X. THE FORMATION OF REDUCED NICOTINAMIDE-ADENINE DINUCLEOTIDE PHOSPHATE IN RELATION TO THE IMPAIRED HEPATIC LIPOGENESIS OF THE RAT ADAPTED TO A HIGH FAT DIET. Surgical evacuation of hematomas preceded or not by ventricular drainage is the useful procedure in most cases. The results were compared with the values in age-matched atopic dermatitis patients and healthy children.

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Gelation of normal serums or immune serums under the influence of sodium salicylate and various bodies. Consensus paper of the Working Group for Oncology of the German Society for Urology. Is hyperthermia the triggering factor for hepatotoxicity induced by 3,4-methylenedioxymethamphetamine (ecstasy)?. By using thiols that present either tri-, tetra-, penta-, or hexa(ethylene glycol) units, the average distance separating the glycol groups and the peptide ligand is altered while the structure and properties of the background remain unchanged. If the group was coded by the full dentition and dental alignment pattern at the same time, its diversity was better than any single pattern. Gap junctions are present in lung airway and alveolar epithelial cells and, in addition to the above roles, might coordinate ciliary beating and surfactant secretion. The effects of diazepam and buspirone were antagonized by flumazenil and WAY-100635, respectively. Mutations affecting the Nodal factors have severe consequences in mammals and fish.

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Existing literature disagrees over whether minimalist running shoes (MRS) improve perceived severity of injuries associated with running in traditional running shoes (TRS). Furthermore, the effects of cytokines on V1A-receptor expression were determined. The National Institute of Standards and Technology (NIST) Standard Reference Materials 2373 is a set of genomic DNA samples prepared from five breast cancer cell lines with certified values for the ratio of the HER2 gene copy number to the copy numbers of reference genes determined by real-time quantitative PCR and digital PCR. Rats were fed by stomach tube with 50 mg/kg B.W./day capsaicin (Sigma) or 0.5 gm/kg B.W./day capsicum fruit crude extract for 60 days. Intraductal Tubulopapillary Neoplasm of the Pancreas Masquerading as Pancreatic Neuroendocrine Carcinoma: Review of the Literature with a Case Report. Declining kidney function leads to progressively dysregulated mineral homeostasis and contributes to vascular calcification and a pro-inflammatory milieu, both of which play a critical role in loss of dialysis vascular access patency. Variations in peripheral blood in young and adult albino rats after administration of sublethal doses, equally divided per body weight.

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An intermediary role for the tremorgenic mycotoxin TR-2 in the biosynthesis of verruculogen. Most likely, the degradation of the stereocomplex hydrogel started with hydrolysis of the carbonate ester, which links the lactate graft to dextran. Conflict of interest disclosure, however, is not systematically nor consistently dealt with by journals. Several hypotheses were presented on the pathogenesis of FALS with SOD1 mutation. HF power, a marker of parasympathetic activity, was lower during non-rapid eye movement (non-REM) and REM sleep in the late-luteal phase than in the follicular phase in women with severe PMS. The role of brain stimulation priming effects in self-deprivation. Middle lobe syndrome is a distinct clinical entity characterized by right middle lobe atelectasis. These reporters also have a dynamic range that is suitable for small molecule screening for compounds that can regulate splicing. To analyze the phylogeny and biogeography of the beetle and provide evidence for the origin of T. 13C-nuclear magnetic resonance relaxation measurements of alpha-lecithin--peptide interaction in model membranes.

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