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Anegyn (Metronidazole)
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Anegyn

Flagyl is an oral antiprotozoal and antibacterial. It is thought to work by entering the bacterial cell, acting on some components of the cell, and destroying the bacteria. Treating certain infections caused by bacteria or amoebas. It may also be used for other conditions as determined by your doctor.

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Also known as: Metronidazole

Description

Anegyn (metronidazole) is an antibiotic that is used to treat bacterial infections of the vagina, stomach, liver, skin, joints, brain and spinal cord, lungs, heart, or bloodstream.

Anegyn is also used to treat trichomoniasis, a sexually transmitted disease caused by a parasite. Usually both sexual partners are treated at the same time, even if one has no symptoms.

Do not use Anegyn to treat any condition that has not been checked by your doctor.

Dosage

In the Female. One-day treatment – two grams of Anegyn, given either as a single dose or in two divided doses of one gram each, given in the same day. Seven-day course of treatment – 250 mg three times daily for seven consecutive days. There is some indication from controlled comparative studies that cure rates as determined by vaginal smears and signs and symptoms, may be higher after a seven-day course of treatment than after a one-day treatment regimen.

The dosage regimen should be individualized. Single-dose treatment can assure compliance, especially if administered under supervision, in those patients who cannot be relied on to continue the seven-day regimen. A seven-day course of treatment may minimize reinfection by protecting the patient long enough for the sexual contacts to obtain appropriate treatment. Further, some patients may tolerate one treatment regimen better than the other.

Pregnant patients should not be treated during the first trimester In pregnant patients for whom alternative treatment has been inadequate, the one-day course of therapy should not be used, as it results in higher serum levels which can reach the fetal circulation.

When repeat courses of the drug are required, it is recommended that an interval of four to six weeks elapse between courses and that the presence of the trichomonad be reconfirmed by appropriate laboratory measures. Total and differential leukocyte counts should be made before and after re-treatment.

Overdose

Single oral doses of Anegyn, up to 15 g, have been reported in suicide attempts and accidental overdoses. Symptoms reported include nausea, vomiting, and ataxia. Oral Anegyn has been studied as a radiation sensitizer in the treatment of malignant tumors. Neurotoxic effects, including seizures and peripheral neuropathy, have been reported after 5 to 7 days of doses of 6 to 10.4 g every other day.

There is no specific antidote for Anegyn overdose; therefore, management of the patient should consist of symptomatic and supportive therapy.

Storage

Store below 77 degrees F (25 degrees C) and protect from light.

Side effects

The most common side effects associated with Anegyn are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Meningitis Not Caused by an Infection, Decreased Neutrophils a Type of White Blood Cell, Habit of Drinking Too Much Alcohol, Alcohol Intoxication, Lower Seizure Threshold, Disorder of the Brain, peripheral neuropathy, prolonged QT interval on EKG, Severe Liver Disease, seizures, Cockayne syndrome

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