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Amantadine is one of the most effective medications to relieve symptoms of Parkinson's disease such as tremors, muscle stiffness and difficulty moving. It increases the amount of a chemical called dopamine in the brain which helps in coordination of body movements.

Other names for this medication:
Amantadine, Amantral, Amantrel, Comantrel, Neaman

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Amantadine is an antidyskinetic medicine. It is used to treat Parkinson's disease (sometimes called "paralysis agitans" or "shaking palsy") and its symptoms, including dyskinesia (sudden uncontrolled movements). It may be given alone or in combination with other medicines (eg, levodopa) for Parkinson's disease. By improving muscle control and reducing stiffness, this medicine allows more normal movements of the body as the disease symptoms are reduced. Amantadine is also used to treat stiffness and shakiness caused by certain medicines that are used to treat nervous, mental, and emotional conditions.

Amantadine is also an antiviral medicine. It is used to prevent or treat certain influenza (flu) infections (type A). It may be given alone or together with flu shots. Amantadine will not work for colds, other types of flu, or other virus infections.

This medicine is available only with your doctor's prescription.


This section provides information on the proper use of a number of products that contain amantadine. It may not be specific to Amantadine. Please read with care.

For patients taking amantadine for Parkinson's disease or movement problems (including dyskinesia) caused by certain medicines used to treat nervous, mental, and emotional conditions:

Take this medicine exactly as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. This medicine comes with a Medication Guide or patient information leaflet. Read and follow these instructions carefully. Ask your doctor if you have any questions. Do not stop using this medicine suddenly without asking your doctor. You may need to slowly decrease your dose before stopping it completely. Improvement in the symptoms of Parkinson's disease usually occurs in about 2 days. However, in some patients, this medicine must be taken for up to 2 weeks before the full benefit is seen.

For patients taking amantadine to prevent or treat flu infections:

Talk to your doctor about the possibility of getting a flu shot if you have not had one yet. This medicine is best taken before exposure or right away after exposure to people who have the flu. To help keep yourself from getting the flu, keep taking this medicine for the full time of treatment. Or if you already have the flu, continue taking this medicine for the full time of treatment even if you begin to feel better after a few days. This will help clear up your infection completely. If you stop taking this medicine too soon, your symptoms may return. This medicine should be taken for at least 2 days after all your flu symptoms have disappeared. This medicine works best when there is a constant amount in the blood. To help keep the amount constant, do not miss any doses. Also, it is best to take the doses at evenly spaced times at day and night. For example, if you are to take two doses a day, the doses should be spaced about 12 hours apart. If this interferes with your sleep or other daily activities, or if you need help in planning the best times to take your medicine, check with your doctor. If you are using the oral liquid form of amantadine, use a marked measuring spoon, oral syringe, or medicine cup to measure each dose correctly. The average household teaspoon may not hold the right amount of liquid.

Take Gocovri® extended-release capsule at bedtime. Swallow whole. Do not crush, break, or chew it. You may also open and sprinkle the extended-release capsules on a teaspoonful of soft food, including applesauce. Take all of the medicine right away without chewing. You may take this medicine with or without food.

Take Osmolex ER™ extended-release tablet in the morning. Swallow whole. Do not crush, open, or chew it.

Do not receive the nasal flu vaccine (live attenuated influenza vaccine) while taking this medicine.

Do not drink alcohol while you are using this medicine.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For treatment of Parkinson's disease or movement problems (including dyskinesia): For oral dosage forms (extended-release capsules): Adults—137 milligrams (mg) once a day at bedtime. Your doctor may increase your dose to 274 mg (two 137 mg capsules) once a day at bedtime after one week. Children—Use and dose must be determined by your doctor. For oral dosage forms (extended-release tablets): Adults—129 milligrams (mg) once a day in the morning. Your doctor may increase your dose each week to a maximum dose of 322 mg (one 129 mg tablet and one 193 mg tablet) once a day taken in the morning. Children—Use and dose must be determined by your doctor. For oral dosage forms (liquid-filled capsules, syrup, and tablets): Adults—100 milligrams (mg) 2 times a day. Your doctor may adjust your dose as needed. Older adults—At first, 100 milligrams (mg) once a day as a single dose. Your doctor may adjust your dose as needed. Children—Use and dose must be determined by your doctor. For the treatment or prevention of flu: For oral dosage forms (capsules, syrup, and tablets): Adults—200 milligrams (mg) or 4 teaspoonfuls once a day as a single dose. Older adults—100 milligrams (mg) once a day as a single dose. Children 9 to 12 years of age—100 milligrams (mg) or 2 teaspoonfuls 2 times a day. Children 1 to 9 years of age—Dose is based on body weight and must be determined by your doctor. The usual dose is 4.4 to 8.8 milligrams (mg) per kilogram (kg) of body weight per day. The dose is divided evenly and given 2 times a day. However, the dose is usually not more than 150 mg per day. Children younger than 1 year of age—Use and dose must be determined by your doctor.


If you overdose Generic Amantadine and you don't feel good you should visit your doctor or health care provider immediately.


Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F) away from moisture and heat. Keep container tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Amantadine are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Be careful with Generic Amantadine while you are pregnant or have nurseling. Generic Amantadine can pass in breast milk and harm your baby. Do not use Generic Amantadine if you are allergic to Generic Amantadine components. Do not use FluMist nasal influenza "live vaccine" while you are being treated with Generic Amantadine and for at least 48 hours after you stop taking Generic Amantadine. The nasal vaccine may not be as effective if you receive it while you are taking Generic Amantadine. Be careful with Generic Amantadine if you have epilepsy or other seizure disorder, congestive heart failure, kidney or liver disease, low blood pressure, eczema, glaucoma, or a history of mental illness, suicide attempt, or drug/alcohol addiction. Be careful with Generic Amantadine if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement. Be careful with Generic Amantadine if you take atropine (Atreza, Sal-Tropine, and others); dicyclomine (Bentyl); glycopyrrolate (Robinul); hyoscyamine (Anaspaz, Levbid, Levsin, Nulev, and others); mepenzolate (Cantil); methscopolamine (Pamine); propantheline (Pro-Banthine); scopolamine (Maldemar, Scopace, Transderm-Scop); quinine (Qualaquin); quinidine (Cardioquin, Quinaglute); diuretic (water pill) such as triamterene (Dyrenium), hydrochlorothiazide (HCTZ, Dyazide, HydroDiuril, Hyzaar, Lopressor, Vasoretic, Zestoretic); phenothiazines such as prochlorperazine (Compazine), thioridazine (Mellaril), and others. Avoid alcohol. Do not stop taking it suddenly.

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Dosimetric analysis of 3D image-guided HDR brachytherapy planning for the treatment of cervical cancer: is point A-based dose prescription still valid in image-guided brachytherapy?. Horizontal transfer of exosomal microRNAs transduce apoptotic signals between pancreatic beta-cells. Our work identifies the TRIM23-TBK1-p62 axis as a key component of selective autophagy and further reveals a role for K27-linked ubiquitination in GTPase-dependent TBK1 activation. Lassa virus (LASV), the most prominent human pathogen of the Arenaviridae, is transmitted to humans from infected rodents and can cause Lassa Fever (LF). Control and labeling experiments to elucidate the mechanism of this elegant metal-free photocatalyzed cyclization reaction were performed. Using the features that were automatically extracted from fluorescence images, our classification method distinguished loss-of-silencing patterns between mutants and wild type with unprecedented precision.

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Subjects included 370 rural completed suicides aged 15-34 years and 370 living controls matched on age, gender and residence (rural/urban location). Protein-protein interactions for 31 drug targets predicted 609 interacting partners. Biochemical and molecular characterization of a novel metalloprotease from Pseudomonas fluorescens strain TBS09. The two scales are coupled because the immune response causes inflammation and adaptation, which affects the biomechanical parameters of the tissue such as his elasticity. Dissimilatory nitrate reduction to ammonium conserves nitrogen in anthropogenically affected subtropical mangrove sediments in Southeast China. Bcpg2 expression is detected early in the infection of three of four plant tissues tested. We present this reaction as one of several potential RecA protein roles in the repair of stalled and/or collapsed replication forks in bacteria. We analysed the relationship between pre-diagnostic prolactin levels and the risk of in situ breast cancer overall, and by menopausal status and use of postmenopausal hormone therapy (HT) at blood donation. Human exposure to arsenic (As) can lead to oxidative stress that can become evident in organs such as the skin, liver, kidneys and lungs. Consecutive blood samples were tested for cell-derived EV, PAI-1 and coagulation parameters.

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Delirium syndromes in two cases of encephalo-trigeminal angiomatosis. Words, using logical connectives, become more and more calculable and developable with the support of mathematical and computer sciences. Improved voltammetric method for simultaneous determination of Pt and Rh using second derivative signal transformation - application to environmental samples. Current smokers were less likely to support smoke-free policies. The duration of torsion less than 5 h yielded partial dysfunction on steroidogenesis. The main concerns for the surgeon in correcting these anomalies are bowel control, urinary control, and sexual function. For suspected recombinant isolates, the genetic structure was determined by full-length genomic analyses. We determined the frequency, patterns of acceptance, and donor and recipient characteristics associated with deceased donor liver organ offers for children who died or were delisted compared with those who underwent transplantation. Since 2013, clinical practice guidelines recommend EGFR mutation testing of non-squamous NSCLC to select advanced-stage patients for first-line treatment using EGFR-TKIs. The larvicidal effects of black pepper (Piper nigrum L.) and piperine against insecticide resistant and susceptible strains of Anopheles malaria vector mosquitoes.

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MicroRNA-199a-3p (miR-199a-3p) is downregulated in sofosbuvir cost with insurance several human malignancies including hepatocellular carcinoma (HCC). Glucagon responses in rabbits with obstructive jaundice and a low energy status in the liver. To investigate the association of job strain, psychological demands and job control on cognitive decline. Photobiologic-mediated fabrication of silver nanoparticles with antibacterial activity. While the protein machinery transducing these external cues has been individually well characterized, little attention has been paid to the role of protein-protein interactions among these molecules. Regulatory Framework for Conducting Clinical Research in Canada.

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Andrographolide reorganise hyperglycaemia and distorted antioxidant profile in streptozotocin-induced diabetic rats. All resident patients diagnosed with primary, invasive breast cancer between January 1, 2006 and December 31, 2010 from four selected hospitals in Beijing were included and followed up until December 31, 2015. These data reveal that FOXA1 is necessary for hormonal responsiveness drug class of glucophage in the developing mammary gland and ERalpha-positive breast cancers, at least in part, through its control of ERalpha expression. Administrative attention must address abuse of neurology nurses by patients and families and develop nursing practice that eliminates the use of avoidance as a way of dealing with this abuse. To estimate the bother using both population- and individual-level bother of lower urinary tract symptoms (LUTS) across a wide age range among men. Dynamics of a two-dimensional vapor bubble confined between superheated or subcooled parallel plates.

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Metal-Organic Polyhedral Core as a Versatile Scaffold for Divergent and Convergent Star Polymer Synthesis. Retention of Skills After Simulation-based Training in Orthopaedic Surgery. Combined features of pemphigus foliaceus and bullous pemphigoid: immunoblot and immunoelectron microscopic studies. Oxidative stress markers along with the genetic polymorphisms of glutathione S-transferase were determined. Building on this finding, baseline REM measurements may serve as a noninvasive biomarker for resilience to trauma or, conversely, to the potential development of posttraumatic stress disorder following trauma. Our landmarks proved to be highly reproducible for the midface while revealing good reproducibility for the lower face. Benzene, polyaromatic hydrocarbons (PAHs) and organic lead compounds were sampled, and the crew answered a questionnaire on acute health glucophage brand name effects.

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Among medical inpatients with nondependent unhealthy alcohol use and those who do not view their drinking as problematic, alcohol-attributable illness may catalyze decreased drinking. This study aims at assessing, using micro-Raman imaging, the effects of some routinely used fixation methods such as formalin-fixation, formalin-fixation/air drying, cytocentrifugation, and air drying on intracellular spectral information. We therefore studied the decay (mass of deadwood, cellulose and lignin) of equal-sized blocks of Picea abies wood in soil-mesocosms over two years in the Italian Alps. We designed and implemented the whole data acquisition and processing pipeline and performed a comprehensive comparison among 40 combinations of different data preprocessing and classification techniques. Disturbances of rhythm and atrio-ventricular conduction in digitalis overdose. This retrospective analysis investigated the effectiveness and side-effects of combined hyperthermia and radiation therapy in locally recurrent breast cancer after primary modified radical mastectomy.

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Identification of patients whose likelihood for acute cardiac pathology was low (stable angina, atypical chest pain, other pathology) or high (myocardial infarction, unstable angina). Myenteric ganglia were increased in size to as wide as the circular muscle. Continuous hepatic arterial infusion of 5-fluorouracil for unresectable colorectal liver metastases: phase II study. Prenatal maternal stress and wheeze in children: novel insights into epigenetic regulation. Incredible structural variation in plastid genomes (plastomes) and highly accelerated evolutionary rates have been reported in selected lineages and functional groups of genes in both plastomes and mitochondrial genomes (mitogenomes), and these phenomena have been implicated in cytonuclear incompatibility. Hospitalized patients with a primary diagnosis of peptic ulcer disease were selected. Because we found higher serum 25-hydroxyvitamin D (25(OH)D) levels among smokers than among non-smokers with analyses using an electrochemiluminescence immunoassay (ECLIA) from Roche, the purpose of the present study was to examine whether this difference between smokers and non-smokers was maintained using other serum 25(OH)D assays. Improved vectors for Agrobacterium mediated genetic manipulation of Hypholoma spp. To solve the super high-dimensional estimation problem with short data length, we develop a multi-trial, sparse model estimation method utilizing B-spline basis functions with a large range of temporal resolutions and a regularized logistic classifier.

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Among these genes we find the non-coding snoRNA genes as a large novel class of Myc targets. In enamel, AD35 had higher bond strength when rubbed for at least 10 s, while application for 5 s generated lower bond strength. Central to this discussion is the notion that the endoplasmic reticulum is a reservoir of viable but inefficiently processed wild-type protein folding intermediates whose biogenesis can be facilitated by PCs to increase functional pools. This study aimed to determine whether single nucleotide polymorphisms (SNPs) in genes involved in DNA repair or metabolism of taxanes or platinum could predict toxicity or response to first-line chemotherapy in ovarian cancer. Biphasic synovial sarcoma of the epiglottis: Case report and literature review. We report a case of chronic osteomyelitis with subsequent mandible fracture, which was successfully treated with the use of a reconstruction plate and antibiotic therapy. These proton transfer steps, involving the tetrapyrrole and a nearby histidine, also enable thermal back-isomerization of the chromophore via keto-enol tautomerization to afford the initial dark state. A Keypoint EMG/EP system was used to test BCR and PSEPs, and the latencies and amplitudes were recorded for statistical analyses.

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Practical Assessment of Bronchoscopically Inserted Fiducial Markers for Image Guidance in Stereotactic Lung Radiotherapy. The high quantum yield of fluorescence, high efficiency of FRET (R(o) is estimated to be approximately 60 A), photostability, and localization in the central hydrophobic region of a bilayer all make this pair of probes quite promising for detecting fusion. New insights in the study of virus and host biology in the context of viral infection are made possible by the development of model systems that faithfully recapitulate the in vivo viral life cycle. No single animal model is able to encompass all of the variables known to affect human ischemic stroke. Consequently, the lung inflation/deflation RC and RnP components had the same duration, the respiratory frequency changes affected in the same way both waveforms and the RnP amplitude increased linearly with the lung inflation in all tested pigs (R2 values between 0.85 and 0.99). Diagnostic performance improved when suppression was defined by two consecutive suppressed viral loads compared with one. In the pilot it proved feasible to apply the instrument and generate the intended information. The Clinical Benefits of Ultrasound-Guided Thoracic Epidural Placement. PCT was superior to CRP in the diagnosis of infection during the study period. The fluidisation ensures prevention and successful treatment of pressure sores, a comfortable and less stressful environment than conventional care, a reduction in pain, ease of wound care, discourages a bacterial persistence and reduces the work of the nurse.

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Mutations in MTP which result in an absence of MTP function have been shown to cause abetalipoproteinemia. Identification and functional characterization of eight CYP3A4 protein variants. These findings, together with the suggestion from the literature that glycodelin prevacid 15mg capsule may have immunosuppressive properties, suggest that glycodelin might play an important role in neovascularization during embryogenesis and tumor development. Multimeric species in equilibrium in detergent-solubilized Na,K-ATPase. Effect of type of instructional format on nursing student cue recognition of pulmonary edema: a pilot study.

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