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Alprasert (Alprazolam)

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Alprasert is used to treat anxiety and panic disorders. It belongs to a class of medications called benzodiazepines which act on the brain and nerves (central nervous system) to produce a calming effect. It works by enhancing the effects of a certain natural chemical in the body (GABA). Alprasert is mostly used to treat anxiety disorders, panic disorders, and nausea due to chemotherapy. Alprasert may also be indicated for the treatment of generalized anxiety disorder, as well as for the treatment of anxiety conditions with co-morbid depression. The FDA label advises that the physician should periodically reassess the usefulness of the drug.

Other names for this medication:
Aldip, Aleez, Alltop, Alpradol, Alpranex, Alprasan, Alprocontin, Alprose, Alrif, Alzoax, Alzolite, Alzoset, Anxicalm, Anxigo, Anxyl, Axnil, Calmtec, Ecsit, Emcalm, Exiten, Fluti, Fluwel, Fluxozam, Imprax, Jolistar, Mcalm, Notence, Pifzot, Prolam, Pyrex, Resolin, Samitol, Somnia, Sowel, Suzilam, Tancalm, Tenzorid, Trika, Xycalm, Zolent, Zomark

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Xenical, Zyrtec, Eulexin, Cardizem, Leukeran, Starlix, Arreno, Zicam, Lordivas, Domaci, Azitrox, Chempride, Mortrin,

Also known as: Alprazolam


Alprasert is a benzodiazepine (ben-zoe-dye-AZE-eh-peen). Alprazolam affects chemicals in the brain that may be unbalanced in people with anxiety. Alprasert is used to treat anxiety disorders, panic disorders, and anxiety caused by depression.

You should not use Alprasert if you have narrow-angle glaucoma, if you also take itraconazole or ketoconazole, or if you are allergic to Alprasert or similar medicines (Valium, Ativan, Tranxene, and others).

Alprazolam may be habit-forming. Misuse of habit-forming medicine can cause addiction, overdose, or death.

Do not drink alcohol while taking Alprasert. This medication can increase the effects of alcohol. Alprazolam may be habit-forming and should be used only by the person for whom it was prescribed. Keep the medication in a secure place where others cannot get to it.


This section provides information on the proper use of a number of products that contain alprazolam. It may not be specific to Alprasert. Please read with care.

Take this medicine only as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. If too much of this medicine is used for a long time, it may become habit-forming (causing mental or physical dependence) or cause an overdose.

This medicine should come with a Medication Guide. Read and follow the instructions carefully. Ask your doctor if you have any questions.

Swallow the extended-release tablet or tablet whole with a full glass of water. Do not break, crush, or chew it.

If you are using the orally disintegrating tablet, make sure your hands are dry before you handle the tablet. Do not remove the tablets from the bottle until you are ready to take it. Place the tablet immediately on the top of your tongue. It should melt quickly and be swallowed with saliva.

If you are using the oral liquid, measure the dose with a marked measuring spoon, oral syringe, or medicine cup.

Do not eat grapefruit or drink grapefruit juice while you are using this medicine.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For anxiety: For oral dosage forms (solution, tablets, or orally disintegrating tablets): Adults—At first, 0.25 to 0.5 milligram (mg) 3 times a day. Your doctor may increase your dose as needed. However, the dose is usually not more than 4 mg per day. Older adults—At first, 0.25 mg 2 or 3 times a day. Your doctor may increase your dose as needed. Children—Use and dose must be determined by your doctor. For panic disorder: For oral dosage form (extended-release tablets): Adults—At first, 0.5 to 1 milligram (mg) taken in the morning once a day. Your doctor may increase your dose as needed. However, the dose is usually not more than 10 mg per day. Older adults—At first, 0.5 mg taken in the morning once a day. Your doctor may increase your dose as needed. Children—Use and dose must be determined by your doctor. For oral dosage forms (solution, tablets, or orally disintegrating tablets): Adults—At first, 0.5 milligram (mg) 3 times a day. Your doctor may increase your dose as needed. However, the dose is usually not more than 10 mg per day. Older adults—At first, 0.25 mg 2 or 3 times a day. Your doctor may increase your dose as needed. Children—Use and dose must be determined by your doctor.


Seek emergency medical attention if you think you have used too much of this medicine. An overdose of Alprasert XR can be fatal.

Overdose symptoms may include extreme drowsiness, confusion, muscle weakness, loss of balance or coordination, feeling light-headed, fainting, and coma.


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

It is very important to protect the orally disintegrating tablets from moisture. Remove and throw away any cotton packaging from the medicine bottle when you first use the medicine.

Detailed Alprasert XR dosage information

Side effects

The most common side effects associated with Alprasert are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Do not use Alprasert XR if you have:

narrow-angle glaucoma; if you are also taking itraconazole (Sporanox) or ketoconazole (Nizoral); or if you are allergic to alprazolam or to other benzodiazepines, such as chlordiazepoxide (Librium), clorazepate (Tranxene), diazepam (Valium), lorazepam (Ativan), or oxazepam (Serax).

Before taking Alprasert XR, tell your doctor if you are allergic to any drugs, or if you have:

asthma, emphysema, bronchitis, chronic obstructive pulmonary disorder (COPD), or other breathing problems; glaucoma; kidney or liver disease (especially alcoholic liver disease); a history of depression or suicidal thoughts or behavior; or a history of drug or alcohol addiction.

If you have any of these conditions, you may need a dose adjustment or special tests to safely take this medication.

It is dangerous to try and purchase Alprasert XR on the Internet or from vendors outside of the United States. Medications distributed from Internet sales may contain dangerous ingredients, or may not be distributed by a licensed pharmacy. Samples of alprazolam purchased on the Internet have been found to contain haloperidol (Haldol), a potent antipsychotic drug with dangerous side effects. For more information, contact the U.S. Food and Drug Administration (FDA) or visit

FDA pregnancy category D. Alprasert XR can cause birth defects in an unborn baby. Do not use Alprasert XR without your doctor's consent if you are pregnant. Tell your doctor if you become pregnant during treatment. Use an effective form of birth control while you are using this medication. Alprazolam can pass into breast milk and may harm a nursing baby. Do not use Alprasert XR without telling your doctor if you are breast-feeding a baby.

The sedative effects of Alprasert XR may last longer in older adults. Accidental falls are common in elderly patients who take benzodiazepines. Use caution to avoid falling or accidental injury while you are taking Alprasert XR. Do not give this medication to anyone under 18 years old.

Alprasert XR pregnancy and breastfeeding warnings (more detail)

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The autonomy questionnaire has been used to determine clinical symptom of ANS involvement. The cDNA for the S genome segment of Hantaan virus was reverse-transcribed from the total RNA of organs of the infected mice. This study examined how the rate of learning, after high- or low-value reward outcomes, can influence future transfers into value-driven attentional capture. Genetic distance was calculated through the Jaccard similarity index and genetic variability through cluster analysis using the unweighted pair group method with arithmetic mean, resulting in dendrograms for both morphological analysis and molecular analysis. Records maintained at the NMCP, the district health services, the Health Information and Management System, the National Laboratory on malaria diagnosis and entomological data of the NMCP were reviewed. Dogs with lower doses per cell turnover developed a very high frequency of lung cancer. Percutaneous Needle Puncture Technique to Create a Rabbit Model with Traumatic Degenerative Disk Disease. Mechanisms underlying production of animal coloration can affect key traits besides coloration. The histologic and immunohistochemical features of MDEA have been described in case reports and in small series, but correlation of these findings with ultrastructural examination has not been documented.

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