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Alparazole (Alprazolam)

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Alparazole is a potent, short-acting benzodiazepine anxiolytic—a minor tranquilizer. It is commonly used for the treatment of anxiety disorders, especially of panic disorder. It's also used in the treatment of generalized anxiety disorder (GAD) or social anxiety disorder. It was the 12th most prescribed medicine in the United States in 2010. Alparazole, like other benzodiazepines, binds to specific sites on the GABAA receptor. It possesses anxiolytic, sedative, hypnotic, skeletal muscle relaxant, anticonvulsant, amnestic, and antidepressant properties. Alparazole is available for oral administration as compressed tablets (CT) and extended-release capsules (XR).

Other names for this medication:
Aderta, Alpron, Alpronit, Alprop, Alprose, Alprosym, Alprozam, Altok, Altrex, Alzocum, Alzolam, Anilam, Ansilumirm, Anxiflu, Anxorel, Balzam, Benzax, Cozac, Depflu, Destres, Erazol, Esteem, Exiten, Faxtin, Flunix, Fluprax, Fultop, Golprax, Kaprolam, Mediprex, Nitril, Orten, Pecalm, Riolam, Serex, Serxanti, Somnia, Stresnil, Xylonite, Zamitol, Zepro, Zodia, Zolorest, Zopic

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Also known as: Alprazolam


Alparazole (alprazolam) is a benzodiazepine (ben-zoe-dye-AZE-eh-peen). It is thought that alprazolam works by enhancing the activity of certain neurotransmitters in the brain.

Alparazole is used to treat anxiety disorders and anxiety caused by depression.

Alparazole is also used to treat panic disorders with or without a fear of places and situations that might cause panic, helplessness, or embarrassment (agoraphobia).

It is dangerous to purchase Alparazole on the Internet or outside the United States. The sale and distribution of medicines outside the U.S. does not comply with safe-use regulations of the Food and Drug Administration (FDA). These medications may contain dangerous ingredients, or may not be distributed by a licensed pharmacy.


This section provides information on the proper use of a number of products that contain alprazolam. It may not be specific to Alparazole XR. Please read with care.

Take this medicine only as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. If too much of this medicine is used for a long time, it may become habit-forming (causing mental or physical dependence) or cause an overdose.

This medicine should come with a Medication Guide. Read and follow the instructions carefully. Ask your doctor if you have any questions.

Swallow the extended-release tablet or tablet whole with a full glass of water. Do not break, crush, or chew it.

If you are using the orally disintegrating tablet, make sure your hands are dry before you handle the tablet. Do not remove the tablets from the bottle until you are ready to take it. Place the tablet immediately on the top of your tongue. It should melt quickly and be swallowed with saliva.

If you are using the oral liquid, measure the dose with a marked measuring spoon, oral syringe, or medicine cup.

Do not eat grapefruit or drink grapefruit juice while you are using this medicine.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For anxiety: For oral dosage forms (solution, tablets, or orally disintegrating tablets): Adults—At first, 0.25 to 0.5 milligram (mg) 3 times a day. Your doctor may increase your dose as needed. However, the dose is usually not more than 4 mg per day. Older adults—At first, 0.25 mg 2 or 3 times a day. Your doctor may increase your dose as needed. Children—Use and dose must be determined by your doctor. For panic disorder: For oral dosage form (extended-release tablets): Adults—At first, 0.5 to 1 milligram (mg) taken in the morning once a day. Your doctor may increase your dose as needed. However, the dose is usually not more than 10 mg per day. Older adults—At first, 0.5 mg taken in the morning once a day. Your doctor may increase your dose as needed. Children—Use and dose must be determined by your doctor. For oral dosage forms (solution, tablets, or orally disintegrating tablets): Adults—At first, 0.5 milligram (mg) 3 times a day. Your doctor may increase your dose as needed. However, the dose is usually not more than 10 mg per day. Older adults—At first, 0.25 mg 2 or 3 times a day. Your doctor may increase your dose as needed. Children—Use and dose must be determined by your doctor.


If you have been prescribed Alparazole for medical reasons, the best way to avoid a Alparazole overdose is to adhere to prescribed orders—closely monitor your dose and the time at which you take your medication. Track your Alparazole consumption in a notebook or on your phone. If you notice that you are taking a higher dose of the drug, taking the drug more often, or you want to consume more of the drug, talk with your doctor immediately.


Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details.

Side effects

The most common side effects associated with Alparazole are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of alprazolam in the elderly. However, elderly patients are more likely to have unwanted effects (eg, severe drowsiness, dizziness, confusion, clumsiness, or unsteadiness) and kidney, liver, or lung problems, which may require caution and an adjustment in the dose for patients receiving this medicine.

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Removal of tumor poses several anesthetic challenges and perioperative morbidity or mortality. Reply to the Editor--Detection of long QT syndrome in the community. We postulated that high levels of iNOS may increase the invasive and metastatic potential of colon carcinoma and could be indicative of survival potential. Acquired somatic TP53 or PIK3CA mutations are potential predictors of when polyps evolve into colorectal cancer. Competence factors of retinal pigment epithelium cells for reprogramming in the neuronal direction during retinal regeneration in newts. The profile of salivary total LDH enzymes is similar to that found in oral epithelium, indicating that the major source of salivary LDH is probably the oral epithelium-shedding cells. Here, we explore the potential epigenetic gene regulatory functions of key histone modifications during tumor resistance in a mouse Lewis lung carcinoma (LLC) cell line. This article provides an approach to assessment and management of TB in travellers, including a guide to pre- and post-travel evaluation, testing and vaccination. In this study, we developed a simple and efficient system to direct endothelial differentiation of mouse embryonic stem cells (ESCs) using a controllable chitosan nitric oxide (NO)-releasing hydrogel (CS-NO).

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in mice, after which the morphology of the particles was thoroughly studied with transmission electron microscopy, micro-computed tomography and X-ray diffraction. Intelligence (IQ), language, attention, memory, visual-spatial, and executive functioning were assessed with internationally validated, neuropsychological tests and questionnaires. Comparative study of the chemical composition of wild and cultivated beans (Phaseolus vulgaris). Health risk assessment of rare earth elements in cereals from mining area in Shandong, China. Randomized double-blind placebo trial of duloxetine in perioperative spine patients. No reliable human studies are available for health evaluation of 2-butanone oxime in indoor air.

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Subsite affinities and disposition of catalytic amino acids in the substrate-binding region of barley 1,3-beta-glucanases. Converging reports indicate that face images are processed through specialized neural networks in the brain -i.e. In addition, CD spectroscopy was used to follow changes in secondary and tertiary structures upon thermal stress of the protein. Adult spontaneously hypertensive rats were treated for 1 or 2 weeks with 30 mg./kg. The patient is a 42-year-old man who is 6 months status post an open distal tibia-fibula fracture treated surgically, and presents complaints of persistent right ankle pain. Do gender and ethnic differences in fasting leptin in Indians and Creoles of Mauritius persist beyond differences in adiposity?. To date, the mechanisms underlying global downregulation of miRNAs in cancer remain largely unclear. Mixtures achieved yields comparable to the best performing monocultures whilst enhancing yield stability despite being subject to multiple predicted and unpredicted abiotic and biotic stresses including brown rust (Puccinia hordei) and lodging. Combination of geo- pedo- and technogenic magnetic and geochemical signals in soil profiles - Diversification and its interpretation: A new approach.

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Osseointegrated implants placed in the microvascularized grafted bone offer an opportunity for improved function and patient satisfaction. G-protein-coupled receptor signaling and receptor tyrosine kinase (RTK) signaling are two mechanisms of transmembrane communication used by numerous extracellular agents and stimuli. Rhodomollanol A, a Highly Oxygenated Diterpenoid with a 5/7/5/5 Tetracyclic Carbon Skeleton from the Leaves of Rhododendron molle. As we learn more about it, we appreciate the striking similarities that exist in the clinical manifestations of this disease across species. Areas specifically more active in CIS patients compared to the other study groups were found in the left medial superior frontal gyrus and right anterior cingulate cortex, whereas SPMS patients selectively activated the left parahippocampal gyrus and left superior temporal pole (STP). Theorists and researchers have demonstrated multiple trajectories of symptoms following disasters ceclor medication class (Ecology and Society, 13, 2008, 9), highlighting the importance of obtaining more knowledge about exposed youth who demonstrate resilience as well as those who suffer chronic difficulties. Moreover, synchronous bilateral breast cancer is extremely rare in men.

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Cytomegalovirus reactivation is often diagnosed in allogeneic hematopoietic cell transplant recipients and therefore could lead to CMV-related disease, involving many organs in these immunocompromised patients. Female dominance in captive gray mouse lemurs (Microcebus murinus). Development of a Protocol for Successful Palliative Care Consultation in Population of Patients Receiving Mechanical Circulatory Support. Thus, decisions do not occur in isolation but rather are tightly embedded in these streams of temporal dependencies. Moreover, the differential responses of the two rice lines to chilling stress were found to correlate with the transcription factor OsWRKY53, which was predicted target of the respective microRNA (miRNA) novel-m0586-5p. Evidence for a carbonic anhydrase-related protein in the brain of rainbow trout (Oncorhynchus mykiss). Rilpivirine and Doravirine Have Complementary Efficacies Against NNRTI-Resistant HIV-1 Mutants. Electrophoretic patterns of the ATCC type strains allowed identification of the strains to the level of species. In addition, drug-resistant monitoring has been established in the country, along with the development of molecular testing capacity for the Plasmodium falciparum parasite at the National Public Health Laboratory. We use numerical simulations to study the properties of a model lamellipodium as it disassembles by filament severing.

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Regarding the pulmonary arteries the image quality showed excellent results for the central and segmental arteries. Cyst and tumors arise from tissue remains of odontogenesis, these interactions have been considered to play an important role in the tumorigenesis of odontogenic lesions. A retrospective review was conducted of 133 SCI patients admitted with an acute abdomen in the 16 years prior to this analysis at the Spinal Injuries Unit (SIU) of Princess Alexandra Hospital. Several of these upregulated proteins are related to early pregnancy in other species. This enabled the comparison of anthropometric measurements and indices in children with bronchial asthma in the four studied groups. A plant 35S CaMV promoter induces long-term expression motrin dosage peds of luciferase in Atlantic salmon. Levofloxacin-loaded bone cement delivery system: Highly effective against intracellular bacteria and Staphylococcus aureus biofilms. Both macroalgae (seaweeds) and microalgae (diatoms) contain pharmacologically active compounds such as phlorotannins, fatty acids, polysaccharides, peptides, and terpenes which combat bacterial invasion.

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Optothermally Reversible Carbon Nanotube-DNA Supramolecular Hybrid Hydrogels. Our findings suggest that the escape mutant, V339I, may stabilize a salt bridge network at the P-domain dimer interface that, in an allostery-like manner, affects the conformational relaxation of the P domain and the efficiency of binding. The microfluidic flow assay detects responses to therapeutic intervention (DDAVP). Nanoliter solvent extraction combined with microspot MALDI TOF mass spectrometry for the analysis of hydrophobic biomolecules. The aim of this study was to investigate the incidence of nosocomial catheter- associated UTI and its related factors in hospitalized patients in intensive care units of hospitals affiliated to Mazandaran University of Medical Sciences, in 2014. The histologic changes described in the cochlea and cochlear nerve represent the effects of ischemia resulting from inadvertent cutting of the blood supply during acoustic tumor removal. In this retrospective study stage III and IV ovarian cancer patients who received debulking surgery from 2006 to 2015 were included. The mitochondria-targeted antioxidant Szeto-Schiller (SS) peptide is a candidate molecule. Body mass indices and haemoglobin levels were used as indirect measures of nutritional status.

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Neurogenic inflammation has for decades been considered an important part of migraine pathophysiology. strain ADP atrazine-degradation pathway is encoded by two sets of genes: the constitutively expressed atzA, atzB and atzC, and the strongly regulated atzDEF operon. The effect of ZFP403 on cell proliferation was determined by colony formation assays. Nifedipine blocked induction of HSP70 by PCP in cingulate, neocortex, and insular cortex but only partially blocked HSP70 in piriform cortex and amygdala. Two mutations of the Gsalpha gene in two Japanese patients with sporadic pseudohypoparathyroidism type Ia. To characterize the professional experiences of non-US born IMGs from limited-resource nations practicing primary care in the US. We evaluated 30 randomly selected AKs from 25 recipients of solid organ transplants and compared their histologic features to those of 50 AKs from 45 patients who were not immunosuppressed. Future work should evaluate the impact of visiting multiple EDs on care utilization and outcomes and explore systems for improving access to patient records across care centers. Direct imaging in a water layer of human chromosome fibres composed of nucleosomes and their higher-order structures by laser-plasma X-ray contact microscopy. Our data showed that redox system elements are differentially expressed in newly diagnosed MS patients, or patients receiving either interferon or immunosuppressive treatments.

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Finding and protecting the facial nerve are a challenge for the surgeon performing parotid surgery. Placement of a cervical collar increases the optic nerve sheath diameter in healthy adults. The difference between ADC values and histological T stage were significantly different. Translating the science into practice: shaping rehabilitation practice to enhance recovery after brain damage. Bulimia nervosa in a Canadian community sample: prevalence and comparison of subgroups. This complete reduction is associated clinically with better function. Emergency sonography supports point of care diagnostics to clarify the possible causes of hemodynamic and respiratory instability, e.g. Teleconsultation in psychology: the use of videolinks for interviewing and assessing elderly patients. A cross-linked hyaluronan gel accelerates healing of corneal epithelial abrasion and alkali burn injuries in rabbits.

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Therefore our data are consistent with a model in which PATs modulate the activity of mTORC1 not by transporting amino acids into the cell but by modulating the intracellular response to amino acids. Of a total of 1204 serum samples tested, 624 samples were positive. Psychiatric hospitalists and continuity of care: a comparison of two models. In comparison to GPMVs prepared by extensive treatment with paraformaldehyde (PFA) and dithiothreitol (DTT), our GPMVs were produced from HeLa cells at much lower concentrations of the blebbing agent. Recently, a case of RA was successfully treated using CAM and TAC according to one report. However, GluD2-KO mice showed neither a hypertrophic response nor territorial restoration 7 d postlesion, nor the recovery of PF axons or synapses on postlesion day 30. Fingerprints were prepared on glass slides and paper and then stored under three lighting conditions and two humidity conditions for up to a year. Atmospheric concentrations of HCB showed a decrease by a factor of about 10.

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