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Alfacalcirol (Calcitriol)

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Alfacalcirol is a synthetic version of Vitamin D3 used to treat calcium deficiency with hypoparathyroidism and metabolic bone disease in people with chronic kidney failure.

Other names for this medication:
Actical, Alcee, Alfabond, Alfacal, Alfacalcirol, Alfarich, Arachitol, Arcium, Aristrol, Bonetuf, Calbec, Calcibest, Calcigra, Calcikind, Calday, Caldikind, Caldix, Calosto, Caltive, Caltop, Calvical, Citroj, Coecoral, Denscal, Devita, Dmcal, Duracal, Fovit, Ikmag, Minroset, Netxod, Nutribone, Ostonex, Politrol, Refirm, Rical, Rockbon, Roical, Rolsical, Septriol, Sorvate, Tobalt, Trolec, Vezocal, Zaxial

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Also known as: Calcitriol


Generic Alfacalcirol is a synthetic vitamin D analog which is active in the regulation of the absorption of calcium from the gastrointestinal tract and its utilization in the body. The two known sites of action of Generic Alfacalcirol are intestine and bone. Generic Alfacalcirol receptor-binding protein appears to exist in the mucosa of human intestine. Additional evidence suggests that Generic Alfacalcirol may also act on the kidney and the parathyroid glands. Generic Alfacalcirol is the most active known form of vitamin D3 in stimulating intestinal calcium transport. In acutely uremic rats Generic Alfacalcirol has been shown to stimulate intestinal calcium absorption. The kidneys of uremic patients cannot adequately synthesize Generic Alfacalcirol, the active hormone formed from precursor vitamin D. Resultant hypocalcemia and secondary hyperparathyroidism are a major cause of the metabolic bone disease of renal failure. However, other bone-toxic substances which accumulate in uremia (eg, aluminum) may also contribute. The beneficial effect of Generic Alfacalcirol in renal osteodystrophy appears to result from correction of hypocalcemia and secondary hyperparathyroidism. It is uncertain whether Generic Alfacalcirol produces other independent beneficial effects. Alfacalcirol is also known as Calcitriol. Generic Alfacalcirol treatment is not associated with an accelerated rate of renal function deterioration. No radiographic evidence of extraskeletal calcification has been found in predialysis patients following treatment. The duration of pharmacologic activity of a single dose of calcitriol is about 3 to 5 days. Generic name of Generic Alfacalcirol is Calcitriol. Brand name of Generic Alfacalcirol is Alfacalcirol.


Generic Alfacalcirol is available in capsules (0.25 mcg) and liquid form. Capsules must be swallowed whole. Do not crush or chew them. If you are prescribed the liquid form, use as directed. Follow dosing instructions closely. Do not take this medication with mineral oil or magnesium containing antacids which may reduce its effects. Foods rich in vitamin D include: fortified dairy products, eggs, sardines, cod liver oil, chicken livers and fresh-water fish. Vitamin D is also obtained from periodic exposure to the sun. It is important to maintain a well-balanced diet while taking this medication. Calcium supplements may be recommended in addition to this medication. If you want to achieve most effective results do not stop taking Generic Alfacalcirol suddenly.


If you overdose Generic Alfacalcirol and you don't feel good you should visit your doctor or health care provider immediately.


Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture, light and heat. Keep container tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Alfacalcirol are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Tell your doctor if you have ever had any unusual or allergic reaction to medicines in this group or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

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In this randomised, open-label, multicentre, phase 3 trial (ENESTg1), participants from academic centres were aged 18 years or older and had previously untreated, histologically confirmed, metastatic or unresectable GISTs. Comparative evaluation of oral flupirtine and oral diclofenac sodium for analgesia and adverse effects in elective abdominal surgeries. New parameters describing how knee ligaments carry force in situ predict interspecimen variations in laxity during simulated clinical exams. Finally, our study provides critical information to predict which unstudied lineages may harbor cryptic diversity, and how geology and climate are likely to have shaped their evolutionary history. It has been suggested that these lesions have to be divided into two subtypes with different behaviour and prognosis according to their location around the spinal cord. Sirt1 plays an important role in mediating greater functionality of human ES/iPS-derived vascular endothelial cells. These include the widely used P2Y12 antagonists and the recently developed orally available anticoagulants that directly target factor Xa or thrombin. Case 1 was diagnosed as meningocele resulting from meningeal herniation and case 2 was diagnosed as meningoencephalocele caused by brain tissue herniation. Hemodynamic variations between end-to-side and end-organ flap systems. Unfortunately, SNF rates in legume crops suffer from undiagnosed incompatible/suboptimal interactions between crop varieties and rhizobia strains.

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An in vitro evaluation of the Native American ethnomedicinal plant Eryngium yuccifolium as a treatment for snakebite envenomation. Inflammatory pathways, reactive oxygen species and stress are also known to increase monoamine oxidase-A (MAO-A) and acetylcholinesterase (ACh-E) activity. We also show that Gpr161 is a target of PKA phosphorylation, and that mutation of the PKA phosphorylation site affects ciliary receptor localization. Ciliary beating is asymmetric, composed of clearly distinguished effective and recovery strokes. These different results may be explained by the associations found between fat distribution and hypertension, impaired glucose tolerance and hypertriglyceridemia. Within the pool of G6PI-specific Th cells the frequency of interleukin 17 (IL17), interferon gamma or tumour necrosis factor alpha producers or polyfunctional Th cells (expressing two or more of these cytokines) was higher in treated than in control mice. Preparation and properties of multifunctional sinapic acid corn bran arabinoxylan esters.

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Association Between the Single Nucleotide Polymorphism and the Level of Aquaporin-4 Protein Expression in Han and Minority Chinese with Inflammatory Demyelinating Diseases of the Central Nervous System. It allows operating on the patient in the supine position - similarly as during primary implantation. Toothpastes anti streptococcal property and toxicity were examined in vitro in different intervals of 1, 2, and 5 min. We identified factors contributing to improper disposal of trash into communal toilets, a barrier to operation of the equipment, in low-income communities of Dhaka, Bangladesh. Pincer nail deformity is the extreme, transverse, proximal-to-distal overcurvature of the finger, caused by osteophyte of the distal phalanx, and causing clamp effect on soft tissues and nail ingrowth. By contrast, the human eye ceases retinal neuron production before birth and loss of photoreceptors during life is permanent and a major cause of blindness. However, the potential for such therapies in targeting these epitopes remains uncertain due to a lack of knowledge of the neoepitope landscape in childhood cancer. To investigate the effects of light therapy on serotonin transporter binding (5-HTT BPND ), an index of 5-HTT levels, in the anterior cingulate and prefrontal cortices (ACC and PFC) of healthy individuals during the fall and winter. The AASM approach globally optimizes the landmark updates in the presence of complicated underlying local anatomical contexts. Although the activities represent initiatives in a number of countries and contexts of discrimination, they nonetheless share certain components which are highlighted.

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During the past decade, translocator protein 18 kDa (TSPO), previously named peripheral benzodiazepine receptor, has gained a great deal of attention based on its use as a clinical biomarker of neuroinflammation with therapeutic potential. Thus, there is a need for training as well as increased knowledge and awareness among care and health care professionals regarding signs of adverse effects and the need of continuous evaluation of treatment in this vulnerable group. The role of the dorsal visual processing stream in tool identification. It was also postulated that BABA induces a general amino acid stress response. The left calf had a 4 cm greater circumference without any what is the highest dosage of lexapro symptoms.

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Atypical primary sclerosing cholangitis cases associated with unusual pancreatitis. This hypothesis is supported by the fact that net cage and land cultures produce non-toxic pufferfish that can be made toxic by feeding with a TTX-containing diet. As the V g is changed from 0 V to -20 V, the current level and light-emission intensity in the orange-red range increase by three and two times, respectively, with a forward bias of 20 V in the p-n junction, compared to those at a V g of 0 V. The lack of expression of IkappaBalpha protein was associated with downregulation of IkappaBalpha mRNA and increases in the levels of the mRNA encoding the proteasome alpha2 subunit proteolytic pathway. A modified World Health Organization-Expanded Program on Immunization cluster sampling methods were used for household selection. The high costs of health and social care support for stroke survivors, and the development of new service arrangements, have concentrated growing attention on economic issues. The hematoma was immediately evacuated through a small corticotomy. Our team consists of ED staff, community members who work with youth affected by violence, people who were affected by violence in their youth, and researchers. The congested bile can predict the outcomes of endoscopic stenting for hilar biliary malignancies.

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Recent trends have been shifted to produce composites of nanocellulose for numerous applications among which the most important ones are its use in medical and environmental prospective. Stroke symptoms and risk for incident coronary heart disease in the REasons for Geographic And Racial Differences in Stroke (REGARDS) study. Seasonal appearance of grass pollen allergen in natural, pauci-micronic aerosol of various size fractions. We sought to identify the most important aspects of HRQOL related to caring for an individual with MCI. In sediments with high levels of contamination, release of DGT-labile Cr, Zn, Cu, and Cd occurred, which resulted in high bioaccumulation of these metals in P. Cost analysis of blood surveys for the detection of microfilaria carriers in rural areas.

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Thirty subjects comprising a subgroup of patients recruited to the Musculoskeletal Ultrasound in Critical Illness: Longitudinal Evaluation (MUSCLE) study. We surveyed pediatric cardiology fellows and attendings practicing in the pediatric cardiothoracic intensive care unit (PCTU) of a large, university-affiliated medical center, using structured Likert response items and open-ended questions, prior to and following the transition to 24/7 in-house attending coverage. The association of birth weight with the outcomes (blood pressure, height, body mass index, and waist circumference) was studied through univariate and multivariable linear regression models. The tissue restricted a4 subunit has previously been reported at the plasma membrane in the kidney, inner ear, olfactory epithelium and male reproductive tract. To identify risk factors associated with 30-day unplanned hospital readmissions in adults with cancer. Triple jejuno-jejunal intussusception due to metastatic renal cell carcinoma. MinD plays an important role in Aeromonas hydrophila adherence to Anguilla japonica mucus. Minimizing off-target effects while retaining the desired pharmacodynamic (PD) response can be achieved by reduced exposure for drugs that display kinetic selectivity in which the drug-target complex has a longer half-life than off-target-drug complexes. These findings indicate that gangliosides probably play an important role in brain development.

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