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Alerdain (Desloratadine)
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Alerdain

Alerdain is loratadine in which the ethoxycarbonyl group attached to the piperidine ring is replaced by hydrogen. Alerdain is used to provide symptomatic relieve of allergic symptoms. The major metabolite of loratidine, Alerdain is an antihistamine which is used for the symptomatic relief of allergic conditions including rhinitis and chronic urticaria. It does not readily enter the central nervous system, so does not cause drowsiness. It has a role as a H1-receptor antagonist, an anti-allergic agent and a cholinergic antagonist.

Other names for this medication:
Alerdain, Alerta, Allerdain, Allerde, Allerede, Allergesic, Antialer, Biomon, Dazit, Delorta, Descare, Desent, Deslor, Desloranid, Desloratadine, Desloriv, Desnova, Dilora, Lorday, Loreta, Nelora, Neoloridin, Nucope, Otrivin, Reditabs, Rodera, Tastylora, Veromon

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Also known as: Desloratadine

Description

Cough/cold combinations are used mainly to relieve the cough due to colds, influenza, or hay fever. They are not to be used for the chronic cough that occurs with smoking, asthma, or emphysema or when there is an unusually large amount of mucus or phlegm (pronounced flem) with the cough.

Cough/cold combination products contain more than one ingredient. For example, some products may contain an antihistamine, a decongestant, and an analgesic, in addition to a medicine for coughing. If you are treating yourself, it is important to select a product that is best for your symptoms. Also, in general, it is best to buy a product that includes only those medicines you really need. If you have questions about which product to buy, check with your pharmacist.

Since different products contain ingredients that will have different precautions and side effects, it is important that you know the ingredients of the medicine you are taking. The different kinds of ingredients that may be found in cough/cold combinations include:

Antihistamines—Antihistamines are used to relieve or prevent the symptoms of hay fever and other types of allergy. They also help relieve some symptoms of the common cold, such as sneezing and runny nose. They work by preventing the effects of a substance called histamine, which is produced by the body. Some examples of antihistamines contained in these combinations are:

Bromodiphenhydramine Brompheniramine Carbinoxamine Chlorpheniramine Dexchlorpheniramine Diphenhydramine Doxylamine Phenindamine Pheniramine Phenyltoloxamine Pyrilamine Promethazine Triprolidine

Decongestants—Decongestants produce a narrowing of blood vessels. This leads to clearing of nasal congestion. However, this effect may also increase blood pressure in patients who have high blood pressure. These include:

Ephedrine Phenylephrine Pseudoephedrine

Antitussives—Antitussives help relieve coughing and are some contain a narcotic. These antitussives act directly on the cough center in the brain. Narcotics may become habit-forming, causing mental or physical dependence, if used for a long time. Physical dependence may lead to withdrawal side effects when you stop taking the medicine.

Narcotic antitussives Codeine Dihydrocodeine Hydrocodone Hydromorphone

Non-narcotic antitussives Carbetapentane Caramiphen Dextromethorphan

Expectorants—Expectorants work by loosening the mucus or phlegm in the lungs. The main expectorant used in cough and cold medicines is guaifenesin. Other ingredients added as expectorants (for example, ammonium chloride, calcium iodide, iodinated glycerol, ipecac, potassium guaiacolsulfonate, potassium iodide, and sodium citrate) have not been proven to be effective. In general, the best thing you can do to loosen mucus or phlegm is to drink plenty of water.

Analgesics—Analgesics are used in these combination medicines to help relieve the aches and pain that may occur with the common cold. These include:

Acetaminophen Aspirin Other salicylates such as salicylamide and sodium salicylate

The use of too much acetaminophen and salicylates at the same time may cause kidney damage or cancer of the kidney or urinary bladder. This may occur if large amounts of both medicines are taken together for a long time. However, taking the recommended amounts of combination medicines that contain both acetaminophen and a salicylate for short periods of time has not been shown to cause these unwanted effects.

Anticholinergics—Anticholinergics, such as homatropine may help produce a drying effect in the nose and chest.

These cough and cold combinations are available both over-the-counter (OTC) and with your doctor's prescription.

Do not give any over-the-counter (OTC) cough and cold medicine to a baby or child under 4 years of age. Using these medicines in very young children might cause serious or possibly life-threatening side effects .

Dosage

Usual Adult Dose for Allergic Rhinitis:

5 mg orally once a day Uses: -Relief of nasal and non-nasal symptoms of seasonal allergic rhinitis -Relief of nasal and non-nasal symptoms of perennial allergic rhinitis -Symptomatic relief of pruritus, reduction in the number of hives, and size of hives in patients with chronic idiopathic urticaria

Usual Adult Dose for Urticaria:

5 mg orally once a day Uses: -Relief of nasal and non-nasal symptoms of seasonal allergic rhinitis -Relief of nasal and non-nasal symptoms of perennial allergic rhinitis -Symptomatic relief of pruritus, reduction in the number of hives, and size of hives in patients with chronic idiopathic urticaria

Usual Pediatric Dose for Allergic Rhinitis:

6 to 11 months: 1 mg orally once a day 12 months to 5 years: 1.25 mg orally once a day 6 to 11 years: 2.5 mg orally once a day 12 years and older: 5 mg orally once a day Uses: -Patients 6 months and older: Relief of nasal and non-nasal symptoms of perennial allergic rhinitis -Patients 6 months and older: Symptomatic relief of pruritus, reduction in the number of hives, and size of hives in patients with chronic idiopathic urticaria -Patients 2 years and older: Relief of nasal and non-nasal symptoms of seasonal allergic rhinitis

Usual Pediatric Dose for Urticaria:

6 to 11 months: 1 mg orally once a day 12 months to 5 years: 1.25 mg orally once a day 6 to 11 years: 2.5 mg orally once a day 12 years and older: 5 mg orally once a day Uses: -Patients 6 months and older: Relief of nasal and non-nasal symptoms of perennial allergic rhinitis -Patients 6 months and older: Symptomatic relief of pruritus, reduction in the number of hives, and size of hives in patients with chronic idiopathic urticaria -Patients 2 years and older: Relief of nasal and non-nasal symptoms of seasonal allergic rhinitis

Detailed Alerdain dosage information

Overdose

If you overdose Generic Alerdain and you don't feel good you should visit your doctor or health care provider immediately. Symptoms of Generic Alerdain overdosage: fast heart rate.

Storage

Keep out of the reach of children.

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Do not keep outdated medicine or medicine no longer needed.

Keep the liquid form of this medicine from freezing. Do not refrigerate the syrup.

Side effects

The most common side effects associated with Alerdain are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

You should not use Alerdain-D 24 Hour if you are allergic to desloratadine, loratadine (Claritin), or pseudoephedrine, or if you have:

narrow-angle glaucoma; severe coronary artery disease (clogged arteries); uncontrolled high blood pressure; or bladder obstruction or other urination problems.

Do not use Alerdain-D 24 Hour if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, tranylcypromine, and others.

Tell your doctor if you have ever had:

kidney disease; glaucoma; heart disease or high blood pressure; a seizure (in you or a family member); diabetes; thyroid disorder; or an enlarged prostate.

Alerdain-D 24 Hour should not be given to a child younger than 12 years old.

It is not known whether desloratadine and pseudoephedrine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

You should not breast feed while using Alerdain-D 24 Hour.

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Areas covered in this paper include a review of the patent literature associated with SIRT1 activators, with a focus on therapeutic applications, primarily related to the use of pharmaceuticals and nutraceuticals containing resveratrol (RSV), and the development of second-generation activators unrelated to RSV. Efficient production of (R)-o-chloromandelic acid by deracemization of o-chloromandelonitrile with a new nitrilase mined from Labrenzia aggregata. The value of using heparin as a pharmacologic intervention to induce a positive scintiscan was studied in a patient with chronic occult gastrointestinal bleeding. The larger the number of risk factors, the greater the risk to human health if CWD is transmissible to humans. All of the photoproducts are derived from cation 4 or radical pathways. Multiple linear regression models were used to analyze the influence of ethnicity on each SF-36 scale while adjusting for the influence of socioeconomic status (SES) factors and other determinants of HRQoL. Gate-Tunable Landau Level Filling and Spectroscopy in Coupled Massive and Massless Electron Systems. Renal sodium transport in renin-deficient Dahl salt-sensitive rats. We outline a diagnostic framework for the same and detail an instrumentation layout. Serotonin (5-HT) plays a complex regulatory role in processes like anxiety, depression, aggression, and impulse control.

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Porcine reproductive and respiratory syndrome virus (PRRSV) causes acute mitochondrial dysfunction by elevating the level of reactive oxygen species. Effects of different dosages of oxycodone and fentanyl on the hemodynamic changes during intubation. DETERMINATION OF THE VOLUME OF THE LIVER WITH THE AID OF COLOR PHOTOSCINTIGRAMS. Correlative 3D superresolution fluorescence and electron microscopy reveal the relationship of mitochondrial nucleoids to membranes. Brief Report: Estimating Differences and Ratios in Median Times to Event. The results showed that the CFMEs and CFNEs have very excellent electrochemical behavior and high sensitivity. Immunological and clinical aspects of kidney disease in endemic typhoid fever in Iran. The excretion of propionate and acetate in vitamin B12 deficiency. In the adjusted GBLUP and ventolin generic coupon single-step methods, the genomic relationship matrix was adjusted for the difference of scale between the genomic and the pedigree relationship matrices.

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