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Aldactone (Spironolactone)

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Aldactone is a medication that is primarily used to treat fluid build-up due to heart failure, liver scarring, or kidney disease. It is also used in the treatment of high blood pressure, low blood potassium that does not improve with supplementation, early puberty in boys, acne and excessive hair growth in women.

Other names for this medication:
Aldostix, Amifru, Aquamide, Dyamide, Dytor, Fruselac, Frusis, Lactone, Lasilactone, Metolactone, Spilactone, Spiromide, Spironolactone, Spirotic, Torlactone, Tormax, Torsid, Zator

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Also known as: Spironolactone


Aldactone (spironolactone) is a potassium-sparing diuretic (water pill) that prevents your body from absorbing too much salt and keeps your potassium levels from getting too low.

Aldactone is used to treat heart failure, high blood pressure (hypertension), or hypokalemia (low potassium levels in the blood).

Aldactone also treats fluid retention (edema) in people with congestive heart failure, cirrhosis of the liver, or a kidney disorder called nephrotic syndrome.

Aldactone is also used to diagnose or treat a condition in which you have too much aldosterone in your body. Aldosterone is a hormone produced by your adrenal glands to help regulate the salt and water balance in your body.


You can feel the effects of Generic Aldactone after 2 weeks of treatment. It depends on the health state and other factors of the patient. Take Generic Aldactone tablets orally with water, at the same time every day. Do not crush or chew it. Take Generic Aldactone once (in the morning) or twice a day. If you want to achieve most effective results do not stop taking Generic Aldactone suddenly.


If you overdose Generic Aldactone and you don't feel good you should visit your doctor or health care provider immediately. Symptoms of Generic Aldactone overdosage: diarrhea, vomiting, nausea, red skin rash, loss of energy, slow heartbeat, weakness in legs, feeling drowsy, confusion.


Store below 25 degrees C (77 degrees F). Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Aldactone are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Do not take Generic Aldactone if you are allergic to Generic Aldactone components. Do not take Generic Aldactone if you're pregnant or you plan to have a baby, or you are a nursing mother. Generic Aldactone can harm your baby. Do not take Generic Aldactone if you are taking potassium-sparing diuretics (such as Aldactazide, amiloride (Moduretic, Midamor)), triamterene (such as Maxzide, Dyazide, Dyrenium)). Be careful using Generic Aldactone if you take inhibitors (enalapril (such as Vasotec), fosinopril (such as Monopril), captopril (such as Capoten), benazepril (such as Lotensin), lisinopril (such as Zestril, Prinivil), quinapril (such as Accupril), moexipril (such as Univasc), ramipril (such as Altace), trandolapril (such as Mavik)); oral steroids (dexamethasone (such as Decadron, Dexone), prednisone (such as Deltasone), methylprednisolone (such as Medrol)); aspirin and other nonsteroidal anti-inflammatory medicines (naproxen (such as Aleve, Naprosyn), ibuprofen (such as Advil, Motrin), indomethacin (such as Indocin)); diuretics; barbiturates, phenobarbital; digoxin (such as Digitek, Lanoxicaps, Lanoxin)); high blood pressure medicines, lithium (such as Lithobid, Eskalith); perindopril (such as Aceon).It can be dangerous to use Aldactone if you suffer from or have a history of liver disease, kidney disease, potassium high levels in your blood, problems with urination. Be careful with this drug if you are going to have a surgery. Avoid food with high level of salt. Avoid dehydration. Avoid medicines which cause lightheadedness. You should be careful when you are driving or operating machinery. Do not stop taking Generic Aldactone suddenly.

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Identification of 2-O (indole-3-acetyl)-D-glucopyranose, 4-O-(indole-3-acetyl)-D-glucopyranose and 6-O-(indole-3-acetyl)-D-glucopyranose from kernels of Zea mays by gas-liquid chromatography-mass spectrometry. In accordance, the intact, full-length BADH2 protein (503 residues) appeared exclusively in nonfragrant transgenic lines and rice varieties. This study explores the ability of a catalytic antioxidant, Mn (III) tetrakis (4-benzoic acid) porphyrin (MnTBAP), to protect against neuronal and glial oxidative stress and death after spinal cord injury (SCI). THE MECHANOGRAM OF THE SINGLE-FIBER NEUROMUSCULAR PREPARATION FROM AMPHIBIA (RANA ESCULENTA). Assessment of a modified and optimised method for determining chemical oxygen demand of solid substrates and solutions with high suspended solid content. The small intensity gradient of Galactic cosmic ray helium indicates that either the gradient is further out in the heliosheath or the local interstellar Galactic cosmic ray intensity is lower than expected.

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Detection of global glycosylation changes of serum proteins in type 1 diabetes using a lectin panel and multivariate data analysis. A computer system for interstitial and intracavitary dose calculations. A new linear transfer theory and characterization method for image detectors. Conformational transitions in glycogen phosphorylase reported by covalently bound pyridoxamine derivatives. Isolated splenic vein thrombosis: the curable variceal hemorrhage. When exogenously expressed in quiescent cells, IQGAP3 was capable of inducing cell-cycle re-entry, which was completely inhibited by the MEK inhibitor U0126. The author discusses available computer programs that are easy to learn and can help pharmacists manage time and resources more efficiently. To study the epidemiological status of reticuloendotheliosis virus (REV) infection in ducks. Choice of the most suitable index and its association with selected variables among 10,000 adult males of heterogeneous origin. Synovial chondromatosis of the lumbar spine with compressive myelopathy: a case report with review of the literature.

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To quantify the risk of obesity and its associated metabolic dysfunction on the development of cardiovascular events and mortality in patients with type 2 diabetes. Seventeen extracted maxillary central incisors were measured and compared to clinical and radiographic root lengths obtained by using paralleling technique at various angulations. Thermochemical investigations of associated solutions: calculation of solute--solvent equilibrium constants from solubility measurements. Proteins in the culture supernatant of Staphylococcus aureus PS 47 were subjected to Sephadex chromatography. The present study aimed to investigate this association of HB and BA, and to assess the utility of alpha-fetoprotein (aFP) as a marker in the diagnosis. Inhibition of exosome secretion via Rab27a small interfering RNA prevented ovariectomized-induced osteoblast dysfunction in vivo. Solubilisation of multi walled carbon nanotubes by alpha-pyrene functionalised PMMA and their liquid crystalline self-organisation. The evolution of methotrexate as a treatment for ectopic pregnancy and gestational trophoblastic neoplasia: a review. Aortic valve stenosis-- evaluation of its severity by time and velocity phonocardiographic measurements.

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EFFECTIVENESS OF TABLETS OF THE WHOLE DIGESTIVE ENZYME PREPARATION BIFUTENON ON THE FREQUENTLY OCCURRING MALABSORPTION SYNDROME. In addition, HMT and EHMT exhibited greater effects on the proliferation of bifidobacteria compared with either glucose or high amylose maize starch. Radiologists must be aware of the clinical presentations and imaging features of these neuropathies because they may be the first to suggest these diagnoses. However, when the K88E DNA was cotransfected with wild type PITX2, analogous to the patient genotype, the K88E mutant suppressed the synergism of wild type PITX2 with Pit-1. However, the anticancer mechanism of UA is not clearly understood. Pathology and clinical databases were systematically searched for the presence of dysplastic lesions in inflammatory bowel disease from 1997 to 2004.

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Matrix method for determining steps most rate-limiting to metabolic fluxes in biotechnological processes. In MEG false negative bone scans have to be expected, and radiography is superior. Localization of kidneys using ultrasound during percutaneous kidney biopsy. Previous field and experimental studies have shown that mainly passerine birds are involved in the amplification. Illness experience and coping with gynecological cancer among northeast Thai female patients.

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Additionally, genetically modifying NK cell lines by increasing their expression of cytokines and engineering chimeric tumor antigen receptors could improve their specificity and cytotoxicity. On the death of the patient, biopsies of the metastic liver and lung tissue were performed. In view of the clinical variables obtained on POD3, such as amylase levels in drain effluent, body temperature, and leukocyte count, clinically relevant pancreas-related infections could be predicted well. Pholidae was recovered as monophyletic (synapomorphies: ribs absent, haemonephropophyses present, gill membranes broadly joined, first neural arch fused to centrum, first anal-fin spine very robust, the dorsal fin comprises only spines and the presence of five branchiostegals), with monophyletic genera Pholis and Apodichthys (Rhodymenichthys is monotypic) and Apodichthys and Rhodymenichthys as sister taxa. The norfloxacin tinidazole brand names definition of myocardial infarction during aortocoronary bypass surgery. Mariannaepyrone--a new inhibitor of thromboxane A2 induced platelet aggregation. The TPR motifs in these proteins are necessary and sufficient for mediating the interaction with Hsp70. Grouping this whole set into sets of isoacceptors we have elucidated structural elements that are characteristic to individual isoacceptor tRNAs within the subclasses of aminoacyl tRNA synthetases. Cigarette smoke induced oxidative insult in local population of Pokhara.

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Tyrosine kinase receptor inhibitor-targeted combined chemotherapy for metastatic bladder cancer. Previous reports showed that surgical treatment for nasal polyps may influence asthma evolution. Effect of the castration of male rats at different postnatal periods on the reactivity of hypothalamic neurons to sex hormones. Modern macaque dietary heterogeneity assessed using stable isotope analysis of hair and bone. Chain motions in lipid-water and protein-lipid-water phases: a spin-label and x-ray diffraction study. The concentrations of the two substrates responded to the two independent variables in a complex interactive manner which is not explained by existing models for dual, substitutable substrates. Bilateral pneumothorax is a rare complication of chemotherapy for lung cancer. There was a significant positive relationship between sperm density and seminal plasma zinc concentration in the fertile, but not in the infertile, men.

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The component separation index: a standardized biometric identity in abdominal wall reconstruction. A single, composite end tofranil pm dosage point termed adverse outcome was defined as the occurrence of any of the following: death within 30 days, death before discharge from the hospital, paraplegia, paraparesis, stroke, or acute renal failure requiring dialysis. The waters fall into four fairly distinct and geographically associated groups chiefly characterized by their calcium and magnesium content. Wound healing and transwell assays were performed to evaluate the migration and invasion capacities, respectively. Improving care through health economics analyses: cost of illness and headache. The receiver sensitivity of the RoF up-link with a 6 km single mode fiber and an optical IF signal in an optical double-sideband format was approximately -8.5 dBm and the power penalty for simultaneous frequency downconversion was approximately 0.63 dB.

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Glucose reintroduction triggers the activation of Nrf2 during experimental ischemia reperfusion. Contribution of alpha(2) receptor subtypes to nerve injury-induced pain and its regulation by dexmedetomidine. In brain, the majority of receptors were located on neuropil areas as opposed to neuronal cell bodies. Using a microtiter assay system, the effect of subinhibitory concentrations of amikacin, gentamicin, cephalothin and doxycycline on the surface hydrophobicity and production of acidic polysaccharide by Vibrio vulnificus (8 human isolates, 8 environmental isolates) was determined. In a 72-hr experiment, control labeling and mitotic index curves showed a peak in the light and a peak in the dark with labeling index rhythms of 12.4, 17.7, and 23.6 hr and a 21.4-hr mitotic index rhythm. Here, we examined the peroxidase and molecular chaperone functions of PaAhpC using a site-directed mutagenesis approach by substitution of Ser and Thr residues with Cys at positions 78 and 105 located between two catalytic cysteines. Scl-Ab treatment significantly increased bone volume in the defect in OVX rats over the 3-week time course as examined by either microCT or histology. Discordance between clinical and laboratory findings in a case of respiratory acidosis with grave changes in the blood gas analytical pattern. The important role of the CSAS in the pathophysiology of various forms of hydrocephalus has been largely ignored. Isonicotinic acid hydrazide compounds in the therapy of pulmonary tuberculosis.

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ON THE NECESSITY OF ENDOWING THE PHYSICAL THERAPY SERVICE WITH WARDS. Confidence intervals are no salvation from the alleged fickleness of the P value. Triple-phase nuclear bone scanning is the most sensitive test for the detection of HO. The mechanism of its formation under normal conditions and during paroxystic hypersecretion. Chronic hepatitis C virus infections (HCV) cause a significant public health burden. These data can be used to provide a baseline for measuring future progress toward vaccination of persons with diabetes. The upregulation during incompatible interactions and downregulation during compatible interactions resulted in four- to 30-fold differences between the expression levels in resistant plants and those in susceptible plants.

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