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Adalate (Nifedipine)

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Adalate is a drug that performs by relaxing the muscles inside the heart and blood vessels in order to enable easier blood flow. This enables the heart to have an easier time pumping blood. The active ingredient is nifedipine and it a part of a class of drugs called calcium channel blockers. The primary use of this medication is to help stop chest pain (angina) and help treat high blood pressure problems (hypertension). In addition to this it can also be used in order to heighten the supply of oxygen and blood to the heart and help with a specific blood circulation condition called Raynaud’s phenomenon.

Other names for this medication:
Adipine, Bresben, Calcianta, Calcigard, Cardifen, Casanmil, Citilat, Cordilat, Cordipin, Fedip, Fenamon, Hypan, Lemar, Macorel, Milfadin, Nedipin, Nidipine, Nifatenol, Nifecard, Nifecardia, Nifed, Nifediac, Nifedipino, Nilol, Nipin, Nirena, Nyefax, Sepamit, Tenif, Valni, Vasdalat, Xepalat

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Also known as: Nifedipine


Nifedipine is used alone or together with other medicines to treat severe chest pain (angina) or high blood pressure (hypertension). High blood pressure adds to the workload of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. High blood pressure may also increase the risk of heart attacks. These problems may be less likely to occur if blood pressure is controlled.

Nifedipine is a calcium channel blocker. It works by affecting the movement of calcium into the cells of the heart and blood vessels. As a result, nifedipine relaxes blood vessels and increases the supply of blood and oxygen to the heart while reducing its workload.

This medicine is available only with your doctor's prescription.


This section provides information on the proper use of a number of products that contain nifedipine. It may not be specific to Adalate PA 10. Please read with care.

In addition to the use of this medicine, treatment for your high blood pressure may include weight control and changes in the types of foods you eat, especially foods high in sodium (salt). Your doctor will tell you which of these are most important for you. You should check with your doctor before changing your diet.

Many patients who have high blood pressure will not notice any signs of the problem. In fact, many may feel normal. It is very important that you take your medicine exactly as directed and that you keep your appointments with your doctor even if you feel well.

Remember that this medicine will not cure your high blood pressure, but it does help control it. You must continue to take it as directed if you expect to lower your blood pressure and keep it down. You may have to take high blood pressure medicine for the rest of your life. If high blood pressure is not treated, it can cause serious problems such as heart failure, blood vessel disease, stroke, or kidney disease.

Swallow the extended release tablet whole. Do not break, crush, or chew it. It is best to take this tablet on an empty stomach.

If you are taking the extended-release tablets, part of the tablet may pass into your stool after your body has absorbed the medicine. This is normal and nothing to worry about.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For treatment of chest pain or high blood pressure: For oral dosage form (capsules): Adults—At first, 10 milligrams (mg) three times a day. Your doctor may increase your dose as needed. Children—Use and dose must be determined by your doctor. For oral dosage form (extended-release tablets): Adults—At first, 30 or 60 milligrams (mg) once a day. Your doctor may increase your dose as needed. However, the dose is usually not more than 90 mg once a day. Children—Use and dose must be determined by your doctor.


If you overdose Adalate and you don't feel good you should visit your doctor or health care provider immediately.


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Detailed Nifedipine dosage information

Side effects

The most common side effects associated with Adalate are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Do not take Adalate if you are allergic to Adalate components. Do not take Adalate if you're pregnant or you plan to have a baby, or you are a nursing mother. Adalate can harm your baby. Do not use Adalate in combination with salt substitutes or potassium supplements. If you want to achieve most effective results without any side effects it is better to avoid alcohol. Avoid grapefruit juice during treatment with Adalate. Try to be careful using Adalate if you suffer from kidney disease, liver disease, diseases of the heart or blood vessels (sick sinus syndrome), aortic stenosis, heart failure, low blood pressure, or coronary artery disease. Do not stop taking Adalate suddenly.

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Although statistical significance was not reached, the increased sensitivity has important clinical relevance, as false-positive results are rare. By using a modified Michelson interferometer configuration enabling single-shot measurements of the coherence length, the transition from spontaneous emission to lasing is investigated. A randomised, controlled trial of conventional versus automated weaning from mechanical ventilation using SmartCare/PS. Synthesis of thiophene-2-carboxamidines containing 2-aminothiazoles and their biological evaluation as urokinase inhibitors. Prior cesarean section, anterior placenta, complete placenta previa, placenta accreta, antenatal anemia and delivery before 34 gestational weeks are high risk factors of peripartum hysterectomy in placenta previa patients. A web-based decision support infrastructure has been developed to provide access to SPARROW simulation results on stream water-quality conditions and to offer sophisticated scenario testing capabilities for research and water-quality planning via a graphical user interface with familiar controls. Morphometric characteristics of placental villi in pregnant women with diabetes. The development of illusionary movements and oscillations of the total body mass center in response to labyrinthine stimulation by ascending and descending current was investigated in 37 healthy test subjects.

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Differentiation of mouse nuclear transfer embryonic stem cells into functional pancreatic beta cells. Subclinical pulmonary aspiration from nocturnal GE reflux has been proposed as a cause of asthma. Both neutrophils and chemokines have been proposed as key components in the development of ALI. Coincident counting between the two detectors provides localization of activity upon a multitude of conical surfaces throughout the object, wherefrom the three-dimensional activity distribution can be reconstructed. The effect of ACTH on the corticoid content of the aqueous humor in first and second extraction. In this article, we describe methods by which one can implement this approach in embryos of the South African claw-toed frog Xenopus laevis. Pilot study on the participation of parents in the medication reconciliation process. Prenatal diagnosis (PD) is available to families affected with propionic acidemia (PA), however, it entails a risk of miscarriage. We demonstrate how hidden ambiguities of the species concept can be dealt with and existing controversies can be overcome. There has been some evidence which suggests that HMOs alter the hospitalization rate of the fee for service medical sector.

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The essential role of betaPix in growth factor-stimulated p38 activation was evidenced by the blocking of platelet-derived growth factor-induced p38 activation in the cells expressing betaPix SH3m (W43K) and betaPix DHm (L238R,L239R). Self-perceived competence among medical residents in skills needed to care for patients with advanced dementia versus metastatic cancer. Although individuals with autism spectrum conditions (ASC) have been repeatedly reported to display several kinds of abnormal behavior related to attention deficits, the neural mechanisms underlying these deficits have not been well investigated within the framework of the load dependency of selective attention. World-wide experience with nimesulide confirms that it is an effective anti-inflammatory drug in the treatment of osteoarthritis. These studies have introduced a cationic peptide with a unique structure and an ability to interact with membranes and to affect intracellular synthesis of proteins, RNA, and DNA.

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Purification of DNA antibodies using cibacron blue F3GA affinity chromatography. Sleep apnea-plus: prevalence, risk factors, and association with cardiovascular diseases using United States population-level data. We show that the analytical results can improve the prediction of the output energy in the fiber lasers. The optimization of a lead structure to a development candidate often requires removal of undesirable antitarget activities. Glioblastoma multiforme (GBM) is largely refractory to surgical operation, radiotherapy, and chemotherapy in use today.

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Environmental Protection Agency (EPA) risk assessments and human health risk assessments in peer-reviewed literature illustrate the ways and means of using PBPK models to quantify the pharmacokinetic component of the interspecies and intraspecies uncertainty factors as well as to conduct route to route, high dose to low dose and duration extrapolations. Tryptophan synthetic pathway and its regulation in Chromobacterium violaceum. The anti-aggregatory effects of prostaglandins (PGs) were compared in platelet-rich plasma (PRP) with that in washed platelets (WP). In applying this approach to pluripotent stem cells (PSCs), these studies have improved the biological understanding of these cells, led to the enhanced use and development of antibodies suitable for immunophenotyping and sorting, and contributed to the repurposing of existing drugs without the need for high-throughput screening. In all the groups there was a clear shift from parabasal to superficial vaginal cells, indicating an estrogenic effect and a potential for the treatment of vulvovaginal atrophy. The aim of the study was to investigate the treatment for CI by surveying the ophthalmologists regarding the most common treatment modalities used in India. In the present study, the composition and kinetics of incoming HSV-1 capsids during entry and retrograde transport in axons of human fetal and dissociated rat dorsal root ganglia (DRG) neurons were examined by wide-field deconvolution microscopy and transmission immunoelectron microscopy (TIEM). Conditioned reflexes following destruction of the deep structures of the brain.

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Despite the long-standing history of human plague in Iran, it remains difficult to obtain an accurate overview of the history and current status of plague in Iran. Primary anaplastic lymphoma kinase-negative anaplastic large-cell lymphoma of the breast in a male patient. As geospatial data have become increasingly integral to health and human rights research, their collection using formal address designations or paper maps has been complicated by numerous factors, including poor cartographic literacy, nomenclature imprecision, and human error. The observed induction of the MHC-encoded Hsp70-1 and Hsp70-2 genes might serve as new markers of GVHR and as potentially novel diagnostic tools for GVHD. Genital infection and sperm agglutinating antibodies in infertile men. Effects of a coping intervention on patients with rheumatic diseases: results of a randomized controlled trial.

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The response of the renal circulation in man to constant-speed infusions of l-norepinephrine. The authors mapped cortical regions engaged in a commonly performed picture naming task, seeking differences by semantic category. Yeast Ddi1 has been implicated in cell cycle regulation, DNA-damage response, and exocytosis. This article introduces a computer software technology that has been used at the University of California, San Francisco (UCSF) Medical Center to identify split patient records. A simple kit system for rapid diagnosis of cerebrospinal meningitis in rural areas of developing countries. The Wnt-2b gene is expressed in the intermediate mesoderm and the lateral plate mesoderm in the presumptive chick forelimb region. Patterns in the inhibition of adrenergic response by catecholamines. Finally, an adaptive GC system with dual 2nd-dimensional columns was employed, in conjunction with temperature ramping, in a practical application to separate a mixture of plant emitted volatile organic compounds with significantly shortened analysis time. A selective metabolite array for the detection of phosphometabolites.

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The above results indicated that the 987P protein receptors are piglet BBV-derived Histone H1 proteins. With the convergent series we establish the existence of the manifest electric-magnetic duality in the one-loop effective action of QED. Management of Multiple Mandibular Fractures in a Child with Osteogenesis Imperfecta Using Arch Bar Retained Thermoformed Splints: A Novel Technique. The combination of infrared, Raman, and inelastic neutron scattering (INS) spectroscopies on hydrided and deuterided samples reveals a complete picture of the dynamics of the BH4- and AlH4 anions respectively as well as the lattice. First experience is reported in the application of computerized tomography to tumorous diseases in childhood, being localized in the mediastinum, lungs, abdomen, bones and soft tissue. Does help in decision-making in biology help in decision-making in human sciences and conversely?. Rupture of the anterior cruciate ligament in growing children: surgical or conservative treatment?. This method enables the system to have the ability to tell the texture directional information of the objective. Estrogenic activity and metabolism of n-butyl benzyl phthalate in vitro: identification of the active molecule(s).

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The student-only intervention did not result in a significant reduction in regular smoking compared with the control group. Air plethysmography: the answer in detecting past deep venous thrombosis. Effects of foliage sprays of juvenile hormone analogues on development of Draeculacephala crassicornis. While waiting for data from ongoing large clinical randomized trials to definitively outline the role of aspirin in primary prevention, our study shows that among diabetic patients without previous vascular events, statins but not aspirin reduce thrombotic risk assessed by TG. Reanalysis of data files: dependent hypotheses and a recommendation. In contrast to networks of fluxes, systems of metabolic processes have not been optimized in a comparable manner. This article seeks to describe the morphologic features of one such rare neoplasm. However, as the influence of Brownian motion increases, the fluid stress decreases, especially at lower Mason numbers, and the striped phase eventually disappears, even when the fluid stress is still high. Netherton syndrome is a rare genodermatosis characterized by ichthyosiform scaling, hair shaft abnormalities, and atopic features. The International Knee Documentation Committee Subjective Knee Form provided the best overall measure of symptoms and disabilities that are most important to this population of postoperative articular cartilage repair patients.

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However, the Western blot of the polyclonal antibody displayed a clearly reduced specificity. Disease management of leishmaniasis is appalling due to lack of a human vaccine and the toxicity and resistance concerns with limited therapeutic drugs. Similarly, stem cell-like cancer cells also show an open chromatin structure at both genes, which correlates with high expression levels and mesenchymal fate characteristics. THE SODIUM-POTASSIUM-STIMULATED ADENOSIN E TRIPHOSPHATASE OF RABBIT CILIARY EPITHELIUM. Consequences of telomerase inhibition by BIBR1532 on proliferation and chemosensitivity of chondrosarcoma cell lines. These include five spotted fever rickettsiae, the agent of human granulocytic ehrlichiosis, four species of the B. The present review will focus on (protein) structure-based approaches and illustrates major advances in this novel exciting field which is supposed to massively impact rational drug design in the next decade. Multiple perforations of the gallbladder in the course of cholelithiasis.

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Nickel-Catalyzed Reductive Cross-Coupling of Aryl Bromides with Alkyl Bromides: Et3N as the Terminal Reductant. The aim of present study was to investigate safety and in vivo efficacy of DB14201 extract. Our findings suggest that if a large maxillary haemangioma is diagnosed pre-operatively, the treatment of choice is pre-operative embolisation followed by endoscopic sinus surgery, in order to avoid the surgical complications associated with wide resection. On the poor correlation between the inhibition by methotrexate of dihydrofolate reductase and of deoxynucleoside incorporation into DNA. Indomethacin-responsive hypercalcemia in a patient with renal-cell adenocarcinoma. To observe the expression of receptor activator nuclear factor-kappaB ligand (RANKL) and osteoprotegerin (OPG) in cholesteatoma and to determine their roles in the destruction of bone.

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Glutaraldehyde cross-linking and gel-filtration chromatography indicated that this co-purification is likely due to the ability of Srv to oligomerize. To compare the differences of therapeutic effect of chronic fatigue syndrome treated with the combined therapy of coiling dragon needling and cupping on back and the western medicine therapy with Prednisone. Using the same experimental system, we have now studied whether the inhibition of cNOS alone in adult animals under physiological conditions, i.e. A diabetic model was established in 50 male Wistar rats with streptozotocin intra-peritoneal injection. The greater proportion of newly synthesized collagen was associated with the cell layer. All underwent measurement of carotid-femoral pulse wave velocity (CFPWV) and carotid-radial pulse wave velocity (CRPWV). Hemicape-like sensory disturbance caused by cortical infarction in the postcentral gyrus. Outside the nervous system NKCC1 transcripts were present in many organs and were mostly confined to epithelia.

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Furthermore, both cytochrome c release and apoptosis proceed normally in cells in which mitochondria have been uncoupled. LPS exerts its effects through cytokines, and peripheral or brain administration of LPS activates cytokine production in the brain. This paper offers a critical discussion of current measurement practices, and discusses factors possibly related to the use of discontinuous, time-based observing/recording procedures. In the current study we report four cases who were hospitalized for diabetic foot ulcer with concomitant calcaneal fractures. It is worth evaluating the efficacy of simultaneous B-RTO and PSE in a prospective study. This systematic literature review analyses published serotype data regarding S. Photocatalytic activity of MCM-organized TiO(2) materials in the oxygenation of cyclohexane with molecular oxygen. Along with the availability of SMN-upregulating drugs, identification of the specific cell types in which SMN deficiency induces the disease and delineation of the window of opportunity for effective treatment are key advances in the ongoing path to SMA therapy. Time-courses of ecdysone synthesis by PTTH-activated day 3 larval and day 0 pupal PG were comparable both quantitatively and temporally, but dose-responses of PTTH activation revealed that larval glands were 1.8 times more sensitive to the neurohormone. We compare our approach to traditional complete-case analysis in an application to data obtained from a study of melanoma.

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portulacoides presence (and probably other salt marsh plants) may cause a marked increase in metals concentrations in dissolved phase (pore water or even water column if rhizosediment is re-suspended). The research results from experimenting upon 12 dogs with splenorrhaphies, segmentary resections and partial heterotopic autotransplantations are presented. Different groups were exposed to continuous wave (CW) and to pulse modulated (PM) microwave radiation (MWR) during daily three-hour behavioral sessions. Data were taken on a rectilinear grid over two orthogonal traverses, allowing synthesis of three-dimensional velocity vectors over most of the grid. The literature showed that increased brain oxidative stress affects cardiovascular regulation.

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Waste was isotopically shown also to contribute to the diet of demersal and benthopelagic wild fish collected around the cages. Emergency airway management by non-anaesthesia house officers--a comparison of three strategies. Myelopathy occurring very long after odontoid fracture with atlanto-axoid dislocation. Its major advantages are adhesions, hemostasis, and the promotion of wound healing. These MSC had increased alkaline phosphatase activity, increased expression of type I collagen, osteopontin, and osteocalcin mRNA, and induced matrix mineralization compared with both non-transduced cells and cells transduced with a control adenoviral construct. Even though deficient P2X7R mice present similar neurodevelopmental alterations, they do not develop neonatal seizures. Complications of dental extractions in patients receiving warfarin anticoagulant therapy. The decision-making module, installed between the 1st- and 2nd-dimensional columns, normally comprises an on-column nondestructive vapor detector, a flow routing system, and a computer that monitors the detection signal from the detector and sends out the trigger signal to the flow routing system. Further comparisons of the validity of 4 or 9 weeks treatment require the testing of other compounds with different targets/mechanism of actions, as well as evaluation of dose-response relationships.

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Most of the ATLV was mature type C-virus particle and immature particle could not be detected. Managing chronic sorrow: experiences of patients with multiple sclerosis. Development of an enteral method of immunization against botulism. This shift is believed to be a driving force for the evolution of the large human cortex. Failure to regulate TRAFs may contribute to the enhanced capacity of LMP1 to activate B cells as well as promote B cell transformation. A 53-year-old woman was admitted to our hospital with headache and convulsion. Technically satisfactory but not ideal scans of the common duct could be obtained irrespective of dietary status or time of day. Based on our results, we conclude that rat PATE proteins may contribute to the reproductive and defense functions.

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To investigate the effects of heparin-SOD on pulmonary fibrosis, heparin-SOD was administered to bleomycin (BLM)-treated mice by intraperitoneal injection once a day and the hydroxyproline content in lung was determined per 7days. After administration of doxycycline for 7 days, groups A and B were inoculated orally once a day for 5 days with P. Questionnaire concerning symptoms of chronic obstructive bronchopneumopathy. Our results provide evidence for a type of transmitter-mediated pathway that regulates the PCD of secretory cells in a mitochondrial-caspase-dependent manner. Patterns of joint damage seen on MRI in early hip osteoarthritis due to structural hip deformities. In response to requests from BMETs, the author developed an educational presentation on work-related biohazards. The chosen context is consumer psychology, a field currently dominated by cognitive models of purchase and consumption.

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Technological advancements how to use itraconazole capsules in hindi in the fractionation of plasma in the early 1970s led to the production of immunoglobulin preparations which could be administered intravenously. The gas percolates through the static plug once the gas pressure exceeds the pore capillary entry pressure of the packed grains, and a moving accumulation front is reestablished at the far side of the plug. Mammography screening entails a substantial amount of overdiagnosis. Provider organizations are moving at an acceptable pace to implement I.T. Electrical services in hospitals--15th edition and its application. Improved liquid ion-exchanger microelectrodes made possible the observation of large, rapid decreases in the concentration of extracellular calcium ions during single epileptic spikes. Using double silent substitution, it is possible to generate L-cone and M-cone isolating electroretinograms (ERGs) on a CRT.

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Cynomolgus monkeys, used as an animal model to predict human pharmacokinetics, occasionally show different oral absorption patterns to humans due to differences in their intestinal metabolism. Efficient Synthesis of Highly Photoluminescent Short Dendritic CdSeS/ZnS Quantum Dots for Biolabeling. A geographic analysis of collisions involving child pedestrians in a large Southern California county. We conclude that populations adjacent to the tidal streams are part of a metapopulation that serves as a reserve of genetic variation in the system. In four of the six patients, a focal area of the aortic wall was indistinct on the side of the retroperitoneal hemorrhage at the presumed site of rupture. However, the full-length Ddi2 protein is unable to bind to di-ubiquitin chains. Processed human donor pericardium patch grafting is one useful way to avoid removing exposed scleral buckles, and consequently, sparing patients the risk of recurrent retinal detachment. This report illustrates the potential for two-dimensional sodium dodecyl sulfate polyacrylamide gel electrophoresis (2-DE) and gel analysis to quantify protein levels following RNAi. A modified PulseNet method using higher concentrations of EDTA and proteinase K, together with increased reagent volumes and incubation temperatures resulted in improved results and a more rapid turnaround time compared to PFGE methods currently used.

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