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Actizide (Glipizide)
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Actizide

Actizide is in a drug class known as sulfonylureas. Sulfonylureas work by telling your pancreas to release insulin, which lowers your blood sugar. Actizide tells your pancreas to increase the amount of insulin it produces in your body. Insulin works to lower your blood sugar.

Other names for this medication:
Bimode, Diacon, Diaglip, Dibimet, Dibizide, Glibetic, Glicept, Glimet, Glipicontin, Glipid, Glipiriv, Glipitis, Glipized, Glipmet, Gluconil, Glumin, Glunas, Glylin, Glynase, Glytop, Glyzip, Gpzide, Libiz, Metaglez, Swiglip, Tranase, Zidmin

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Also known as: Glipizide

Description

Actizide is a medication consists in a class of drugs called sulfonylureas. Actizide is used to treat type 2 diabetes. Actizide may be used along with diet, exercise and insulin therapy. Actizide is also known as Glipizide, Glytop SR. Actizide works by controlling blood sugar levels in your organism. Generic name of Actizide is Glipizide. Brand names of Actizide are Actizide, Actizide XL.

Dosage

Usual Adult Dose of Actizide for Diabetes Type 2:

Immediate release: Initial dose: 5 mg orally once a day, 30 minutes before breakfast Maintenance dose: Up to 40 mg in divided doses 30 minutes before a meal of adequate caloric content. Doses may be increased in intervals of 2.5 to 5 mg a day according to blood glucose response. Maximum single dose: 15 mg Maximum daily dose: 40 mg Comments: -At least several days should elapse between titration steps. -If response to a single dose is not satisfactory, dividing that dose may prove effective. Extended Release: Initial dose: 5 mg orally once a day, 30 minutes before breakfast Maintenance dose: 5 to 10 mg orally once a day Maximum daily dose: 20 mg Patients receiving immediate release may be switched safely to extended release tablets once-a-day at the nearest equivalent total daily dose, or titrate to the appropriate extended release dose starting with 5 mg once daily. Combination use: -When adding other blood-glucose-lowering agents to the extended release tablets, the agent should be initiated at the lowest recommended dose. Observe for hypoglycemia. -When adding extended release tablets to other blood-glucose-lowering agents, Actizide XL extended release can be initiated at 5 mg. Start at a lower dose in patients that are more sensitive to hypoglycemia. When transferring patients from insulin to glipizide, the following general guidelines should be considered: -For patients with daily insulin doses of 20 units or less: Discontinue insulin and begin glipizide at usual dosages. -For patients with daily insulin doses greater than 20 units: Insulin dose should be reduced by 50% and glipizide therapy may begin at usual dosages. Comments: -Several days should elapse between titration steps. -Subsequent reductions in insulin dosage should depend on individual patient response. -During the insulin withdrawal period, the patient should test urine samples for sugar and ketone bodies at least three times daily. -Some patients receiving greater than 40 units of insulin daily may need to consider hospitalization during the transition period. Patients Receiving Other Oral Hypoglycemic Agents: -When transferring from longer half-life sulfonylureas: Observe for 1 to 2 weeks for hypoglycemia. -Actizide XL extended release coadministered with colesevelam: Glipizide should be administered at least 4 hours prior to colesevelam. Use: Adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.

Usual Geriatric Dose of Actizide for Diabetes Type 2:

Initial dose: 2.5 mg orally once a day 30 minutes before breakfast Comments: -Maintenance dosing should be conservative to avoid hypoglycemic reactions. -Doses can be adjusted with caution taking into account the degree of hepatic, renal, or cardiac function, and the concomitant disease or other drug therapy. Use: Adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.

Detailed Actizide dosage information

Overdose

If you overdose Actizide and you don't feel good you should visit your doctor or health care provider immediately. Symptoms of Actizide overdosage: hunger, nausea, anxiety, cold sweats, weakness, drowsiness, unconsciousness, coma.

Storage

Store at room temperature below 30 degrees C (86 degrees F) away from moisture and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Actizide are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of glipizide in the elderly. However, elderly patients are more likely to have age-related heart, liver, or kidney problems which may require caution in patients receiving glipizide.

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Service delivery and pharmacotherapy for alcohol use disorder in the era of health reform: Data from a national sample of treatment organizations. Accelerated control of tuberculosis (TB) requires better control measures. Data from numerous clinical trials primarily evaluating the antihyperglycemic effects of multiple GLP-1 RAs have also revealed that changes in most CVD risk markers reported as secondary outcomes have been in favor of GLP-1 RAs treatment. Furthermore, we found that FOXL2 was a direct target of miR-937 and negatively regulated by miR-937. The dimer presents closed or open conformations, which are involved in the substrate binding and release. We theoretically analyze the dependence of second-harmonic generation efficiency on the group index in periodic optical waveguides with loss. One-Stage Colectomy with Intraoperative Colonic Irrigation for Acute Left-Sided Malignant Colonic Obstruction. Further, UAP56 represses the binding of excess amount of NP to RNA possibly by transferring trimeric NP. Enhanced selective adsorption of CO2 on nitrogen-doped porous carbon monoliths derived from IRMOF-3. It was demonstrated that the inhibition efficiency depended on the length and flexibility of the aliphatic chain of the substituent.

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Prevalence and general health status of people with intellectual disabilities in Scotland: a total population study. We found that the first OKT3 injection in human renal allograft recipients led to the release in significant amounts of soluble TNF receptors (TNF-sR55 and TNF-sR75) that are considered main natural inhibitors of TNF bioactivity. At discharge frequencies of less than approximately 250 Hz, spikes propagated faithfully through the axon and axon collaterals, in a saltatory manner. Duration of neuroleptic treatment and prevalence of tardive dyskinesia in late life. In the next day, patients were submitted to transesophageal stimulation with the same protocol.

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Peroxynitrite production, DNA breakage, and poly(ADP-ribose) polymerase activation in a mouse model of oxazolone-induced contact hypersensitivity. Lipid peroxidation was induced by hydrogen peroxide in the absence (control) and presence of antioxidants at low (25 micrograms/ml) and high (250 micrograms/ml) concentrations. This paper presents the first critical review of literature on the use of TM/TH for malaria prevention and treatment in low- to middle-income countries in the Asia-Pacific region. A high-throughput screening assay for the functional delivery of splice-switching oligonucleotides in human melanoma cells. In conclusion, complement opsonization promotes NET release induced by a variety of bacteria, including A. Common Versus Unique Findings on Processing-Based Task Performance in Korean Speaking Children With Cochlear Implants. The use of dimethyl sulfoxide in contact lens disinfectants is a potential preventative strategy against contracting Acanthamoeba keratitis. Then follows an assessment of state reforms and regional policies with effect from 1980.

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Attenuated total reflection infrared spectroscopy (ATR-IR) as an in situ technique for dissolution studies. However, no systematic review has synthesized the evidence, and its effects remain unclear. EFTUD2 Is a Novel Innate Immune Regulator Restricting Hepatitis C Virus Infection through the RIG-I/MDA5 Pathway. The behavior of various body functions during a 7-day rhythm study and the importance of the consciousness of time. Pharmacokinetic evidence of interactions from clinical trials and reports from real-world experience are discussed. Recently we developed an MEF model system for analysis of the role of the tumor suppressor gene DLC1 in cellular transformation (Qian et al., 2012).

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Unravelling the transcriptional regulation of Saccharomyces cerevisiae UGA genes: the dual role of transcription factor Leu3. Cultural concepts and themes of suicidal attempt among Iranian adolescents. The beneficial effects of vortioxetine on anxiety symptoms, functioning, and quality of life are greater in adults with GAD who are working and/or pursuing an education versus the full GAD study population. Control of Cross Talk between Angiogenesis and Inflammation by Mesenchymal Stem Cells for the Treatment of Ocular Surface Diseases. The poor metabolizers, classified by the CYP2C19 genotypes, showed the higher effectiveness in anti-H. Cutting the wrong areas of a tooth exposes the underlying dentin to tensile forces that exceed natural design parameters. Paired t tests were used to compare gapping, ultimate stiffness, and failure loads. The definition of E2F1 role in HCC is not a trivial aspect as it can have significant consequences for the development of novel therapeutic options with E2F1 as target. We aim to determine the bladder smooth muscle pathological changes and dysfunction in chronic prostatitis (CP), to investigate whether resveratrol can improve the urinary dysfunction and the role of c-kit/SCF pathway, that has been associated with the smooth muscle carcinogenesis. We introduce a solution to suggest a conceptual annotation for new entities based on related already indexed documents.

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